dimerization — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T8469	LQZ-7I		Survivin
	LQZ-7I is an inhibitor of surviving-targeting. It orally effectively inhibits xenograft tumor growth and induces survivin loss in tumors		Survivin
T5697	BMS-1166		PD-1/PD-L1
	BMS-1166 is a potent PD-1/PD-L1 interaction inhibitor.		PD-1/PD-L1
T4367	Mycro 3	Mycro-3	c-Myc , Autophagy
	Mycro 3 is potent and selective for c-Myc in whole cell assays.		c-Myc , Autophagy
T6995	Ochromycinone	STA 21,STA21,STA-21	Antibacterial , STAT
	Ochromycinone (STA 21) is a selective STAT3 inhibitor.		Antibacterial , STAT
T21083	TFIIH Modulator-19	TFIIH Modulator19,TFIIH Modulator 19	Others
	TFIIH Modulator-19 induces the dimerization of trichothiodystrophy group A protein to modulate TFIIH transcriptional activity.		Others
T6818	DEL-22379	DEL22379	Apoptosis , ERK
	DEL-22379 is a water-soluble ERK dimerization inhibitor with IC50 of ～0.5 μM.		Apoptosis , ERK
T21082	2,5-Dihydroxybiphenyl	TFIIH Modulator 12,TFIIH Modulator12	Others
	2,5-Dihydroxybiphenyl (TFIIH Modulator12), a small molecule destabilization inducer, induces the dimerization of trichothiodystrophy group A protein to modulate TFIIH transcriptional activity.		Others
T3686	10074-G5		c-Myc , Autophagy
	10074-G5 is an inhibitor of c-Myc-Max dimerization.		c-Myc , Autophagy
T35074	VRT-325	CFcor 325,VRT-534,CFcor325,VRT 325,VRT325,CF-106951,CFcor-325	Others
	VRT-325 can repair folding defects by promoting dimerization of the two NBDs or by promoting folding of the TMD.VRT-325 accelerates the healing rate of CF cell monolayers.		Others
T6908	NSC 228155	NSC228155	EGFR , Epigenetic Reader Domain , DNA/RNA Synthesis , Histone Acetyltransferase
	NSC 228155 is an activator of EGFR, binding to the sEGFR dimerization domain II and modulate EGFR tyrosine phosphorylation.
T7184	Firsocostat	ND-630,NDI-010976,GS-0976	Acetyl-CoA Carboxylase
	Firsocostat (GS-0976) is an inhibitor of acetyl-CoA carboxylase (ACC) dimerization that inhibits human ACC1 and ACC2 activity (IC50s of 2.1 and 6.1 nM, respectively)		Acetyl-CoA Carboxylase
T60160	STX-0119		STAT
	STX-0119 is a selective, orally active STAT3 dimerization inhibitor. STX-0119 inhibits STAT3 transcription with an IC50 of 74 μM.		STAT
T9908	Pembrolizumab		PD-1/PD-L1
	Pembrolizumab is a humanized monoclonal antibody inhibiting the PD-1 receptor and the first in the class of agents called the HER2 dimerization inhibitors that impairs the ability of HER2 to bind to other members of the ...		PD-1/PD-L1
T6308	Stattic	STAT3 Inhibitor V	Apoptosis , STAT
	Stattic (STAT3 Inhibitor V) is a STAT3 inhibitor (IC50=5.1 μM) that selectively inhibits STAT3 activation, dimerization, and nuclear translocation. Stattic has antitumor activity and induces apoptosis.		Apoptosis , STAT
T9909	Pertuzumab		EGFR
	Pertuzumab (anti-HER2) a humanized monoclonal antibody and the first in the class of agents called the HER2 dimerization inhibitors impairs the ability of HER2 to bind to other members of the HER family.		EGFR
T14091	AC-73		Autophagy
	AC-73 is an orally available Cluster of Differentiation 147 (CD147) inhibitor with high bioavailability that selectively disrupts the dimerization of CD147 (the binding site is in the N-terminal IgC2 domain of CD147 incl...		Autophagy
T76776	Emactuzumab	RO 5509554,RG 7155	c-Fms , TAM Receptor
	Emactuzumab(RG 7155) is a monoclonal antibody against colony-stimulating factor-1 receptor targeting tumor-associated macrophages (TAMs) Emactuzumab has antitumor activity and inhibits activation of colony-stimulating fa...		c-Fms , TAM Receptor
T38108	Fulvic Acid		Antioxidant , PDE
	Fulvic Acid is a natural product of humus produced by microorganisms in soil, sediment or aquatic environments. Fulvic acid is a phenolic acid and fungal metabolite isolated from Penicillium for the first time. Fulvic Ac...		Antioxidant , PDE
T10291	α-Truxillic acid		Others
	α-Truxillic acid, known for its anti-inflammatory activities, is produced through the dimerization of two molecules of α-trans-cinnamic acid.		Others
T35159	XCT0135908	XCT 0135908,XCT-0135908
	XCT0135908 is a selectivity agonist of RXR -Nurr1 over a broad range of other RXR dimerization partners but with a rather low potency.