Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ochromycinone (STA 21) is a selective STAT3 inhibitor.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 133.00 | |
5 mg | In stock | $ 328.00 | |
10 mg | In stock | $ 555.00 | |
25 mg | In stock | $ 893.00 | |
50 mg | In stock | $ 1,220.00 | |
100 mg | In stock | $ 1,650.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 328.00 |
Description | Ochromycinone (STA 21) is a selective STAT3 inhibitor. |
In vitro | In cells, STA-21 inhibits Stat3 DNA binding activity, Stat3 dimerization, and Stat3-dependent luciferase activity. STA-21 remarkably inhibits the growth and the survival of the breast carcinoma cells MDA-MB-231, MDA-MB-435s, and MDA-MB-468 that express persistently activated Stat3. [1] In RH30 and RD2 cells, STA-21 also inhibits cell viability and growth and induced apoptosis through caspases 3, 8 and 9 pathways. [2] |
In vivo | In IL-1Ra–KO mice, STA-21 (0.5 mg/kg, i.p.) reduces the arthritis score and the incidence of arthritis by decreasing the proportion of Th17 cells and increasing the proportion of Treg cells expressing FoxP3. [3] |
Cell Research | Human breast cancer cell lines MDA-MB-231, MDA-MB-435s, MDA-MB-453, MDA-MB-468, and MCF7, human ovarian carcinoma cell line Caov-3, and human skin fibroblasts were cultured in DMEM containing 10% FBS and appropriate antibiotics in a 5% CO2 incubator at 37°C. For testing different compounds, the cells were exposed to the compounds for 48 h at a final concentration of 20 or 30 μM, respectively. Then, the cells were harvested and subjected to flow-cytometry analysis.(Only for Reference) |
Synonyms | STA 21, STA21, STA-21 |
Molecular Weight | 306.31 |
Formula | C19H14O4 |
CAS No. | 111540-00-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 2 mg/mL (6.52 mM)
DMSO: 20 mg/mL (65.3 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
You can also refer to dose conversion for different animals. More
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Ochromycinone 111540-00-2 JAK/STAT signaling Microbiology/Virology Stem Cells Antibacterial STAT anticancer STA 21 Bacterial dimerization binding STAT3 Inhibitor antimicrobial STA21 STA-21 inhibit DNA antibiotic inhibitor