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NSC 228155

Catalog No. T6908   CAS 113104-25-9
Synonyms: NSC228155

NSC 228155 is an activator of EGFR, binding to the sEGFR dimerization domain II and modulate EGFR tyrosine phosphorylation.

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NSC 228155 Chemical Structure
NSC 228155, CAS 113104-25-9
Pack Size Availability Price/USD Quantity
5 mg In stock $ 43.00
10 mg In stock $ 61.00
25 mg In stock $ 127.00
50 mg In stock $ 231.00
100 mg In stock $ 401.00
200 mg In stock $ 521.00
1 mL * 10 mM (in DMSO) In stock $ 48.00
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Purity: 99.84%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description NSC 228155 is an activator of EGFR, binding to the sEGFR dimerization domain II and modulate EGFR tyrosine phosphorylation.
Targets&IC50 KIX-KID interaction:0.36 μM
In vitro NSC 228155 promotes transactivation of several RTKs, including ErbB2 and ErbB3, Insulin R and IGF-1 R receptors in the cells. It stimulates dimerization of sEGFR domain II[1]. NSC 228155 can rapidly move across cell membranes and disperse within both cytoplasmic and nuclear compartments. It rapidly generates hydrogen peroxide within cells[2]. NSC 228155 is also a potent inhibitor of KIX-KID interaction(IC50 = 0.36 μM), but it is not particularly selective against CREB-mediated gene transcription in HEK 293T cells[3].
Cell Research MDA MB468 cells serum-starved overnight are pre-incubated (or not) with 10?μM AG1478 or 2?μM PD 153035 for 90?min and then, where indicated, incubated with 100?μM NSC 228155 or CN 009543V or 150?ng/ml EGF or vehicle (0.2% DMSO) for 15?min. Proteins are blotted to nitrocellulose membrane and analyzed with biotinylated anti-pTyr P100, anti-pEGFR Y1068 and anti-EGFR (epitope in cytoplasmic region) antibodies. (Only for Reference)
Synonyms NSC228155
Molecular Weight 290.25
Formula C11H6N4O4S
CAS No. 113104-25-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 12 mg/mL (41.3 mM)

TargetMolReferences and Literature

1. Sakanyan V, et al. Sci Rep. 2014, 4:3977. 2. Sakanyan V, et al. Sci Rep. 2016, 6:21088. 3. Xie F, et al. Bioorg Med Chem Lett. 2013, 23(19):5371-5.

Related compound libraries

This product is contained In the following compound libraries:
Tyrosine Kinase Inhibitor Library Angiogenesis related Compound Library Anti-Breast Cancer Compound Library Histone Modification Compound Library Anti-Hypertension Compound Library Cell Cycle Compound Library Anti-Lung Cancer Compound Library Anti-Cancer Compound Library Reprogramming Compound Library Epigenetics Compound Library

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Keywords

NSC 228155 113104-25-9 Angiogenesis Cell Cycle/Checkpoint Chromatin/Epigenetic DNA Damage/DNA Repair JAK/STAT signaling Tyrosine Kinase/Adaptors EGFR Epigenetic Reader Domain DNA/RNA Synthesis Histone Acetyltransferase Epidermal growth factor receptor NSC-228155 HER1 HATs inhibit NSC228155 Inhibitor HAT ErbB-1 inhibitor

 

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