Powder: -20°C for 3 years | In solvent: -80°C for 1 year
NSC 228155 is an activator of EGFR, binding to the sEGFR dimerization domain II and modulate EGFR tyrosine phosphorylation.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 43.00 | |
10 mg | In stock | $ 61.00 | |
25 mg | In stock | $ 127.00 | |
50 mg | In stock | $ 231.00 | |
100 mg | In stock | $ 401.00 | |
200 mg | In stock | $ 521.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 48.00 |
Description | NSC 228155 is an activator of EGFR, binding to the sEGFR dimerization domain II and modulate EGFR tyrosine phosphorylation. |
Targets&IC50 | KIX-KID interaction:0.36 μM |
In vitro | NSC 228155 promotes transactivation of several RTKs, including ErbB2 and ErbB3, Insulin R and IGF-1 R receptors in the cells. It stimulates dimerization of sEGFR domain II[1]. NSC 228155 can rapidly move across cell membranes and disperse within both cytoplasmic and nuclear compartments. It rapidly generates hydrogen peroxide within cells[2]. NSC 228155 is also a potent inhibitor of KIX-KID interaction(IC50 = 0.36 μM), but it is not particularly selective against CREB-mediated gene transcription in HEK 293T cells[3]. |
Cell Research | MDA MB468 cells serum-starved overnight are pre-incubated (or not) with 10?μM AG1478 or 2?μM PD 153035 for 90?min and then, where indicated, incubated with 100?μM NSC 228155 or CN 009543V or 150?ng/ml EGF or vehicle (0.2% DMSO) for 15?min. Proteins are blotted to nitrocellulose membrane and analyzed with biotinylated anti-pTyr P100, anti-pEGFR Y1068 and anti-EGFR (epitope in cytoplasmic region) antibodies. (Only for Reference) |
Synonyms | NSC228155 |
Molecular Weight | 290.25 |
Formula | C11H6N4O4S |
CAS No. | 113104-25-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
H2O: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 12 mg/mL (41.3 mM)
You can also refer to dose conversion for different animals. More
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NSC 228155 113104-25-9 Angiogenesis Cell Cycle/Checkpoint Chromatin/Epigenetic DNA Damage/DNA Repair JAK/STAT signaling Tyrosine Kinase/Adaptors EGFR Epigenetic Reader Domain DNA/RNA Synthesis Histone Acetyltransferase Epidermal growth factor receptor NSC-228155 HER1 HATs inhibit NSC228155 Inhibitor HAT ErbB-1 inhibitor