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AC-73

Catalog No. T14091 CAS 775294-71-8

AC-73 is an orally available Cluster of Differentiation 147 (CD147) inhibitor with high bioavailability that selectively disrupts the dimerization of CD147 (the binding site is in the N-terminal IgC2 domain of CD147 including Glu64 and Glu73), resulting in inhibition of the CD147/ERK1/2/STAT3/MMP-2 pathway and inhibition of liver cancer cell motility and invasion. AC-73 has antiproliferative activity and induces autophagy in leukemia cells.

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AC-73, CAS 775294-71-8

Pack Size	Availability	Price/USD
1 mg	In stock	$ 45.00
5 mg	In stock	$ 98.00
10 mg	In stock	$ 183.00
25 mg	In stock	$ 322.00
50 mg	In stock	$ 540.00
100 mg	In stock	$ 957.00
500 mg	In stock	$ 1,920.00
1 mL * 10 mM (in DMSO)	In stock	$ 110.00

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Purity: 98.95%

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Description	AC-73 is an orally available Cluster of Differentiation 147 (CD147) inhibitor with high bioavailability that selectively disrupts the dimerization of CD147 (the binding site is in the N-terminal IgC2 domain of CD147 including Glu64 and Glu73), resulting in inhibition of the CD147/ERK1/2/STAT3/MMP-2 pathway and inhibition of liver cancer cell motility and invasion. AC-73 has antiproliferative activity and induces autophagy in leukemia cells.
In vitro	AC-73 (5-10 μM; 24 hours; SMMC-7721 and Huh-7 cells) treatment results in a dose-dependent reduction in the migration ability of SMMC-7721 and Huh-7 cells, as well as a dose-dependent decrease in the invasion of these two HCC cell lines at 24 hours. AC-73 treatment leads to a reduction in HCC metastasis. When treating the two HCC cell lines with AC-73 at a maximum concentration of 20 μM, there are no significant effects on cell viability. AC-73 potentially binds to CD147 at Glu64 and Glu73 in the N-terminal IgC2 domain, where both residues are situated within the dimer interface of CD147.[1] AC-73 (5-10 μM; 24 hours; SMMC-7721 cells), at a concentration of 10 μM, significantly inhibits the mRNA expression of both MMP-2 and MMP-9, with a more pronounced effect on MMP-2, while demonstrating no discernible impact on MMP-1, MMP-3, MMP-7, MMP-11, or MMP-13. AC-73 exhibits a dose-dependent reduction in MMP-2 mRNA levels and protein secretion, as confirmed through RT-qPCR analysis and gelatin zymography experiments.[1] AC-73 (5-20 μM; 6 hours; SMMC-7721 cells), in a dose-dependent manner, attenuates the phosphorylation of ERK1/2 and STAT3.[1]
In vivo	AC-73 (25-50 mg/kg; Injected; daily; for 3 weeks; Male BALB/c nu/nu mice with SMMC-7721 cells) treatment significantly decreases the incidence of metastatic foci in nude mice. AC-73 inhibits the phosphorylation of ERK1/2 and STAT3 in a dose-dependent manner. MMP-2 is also reduced by AC-73. AC-73 could not inhibit tumor cell proliferation in vivo.[1]

Molecular Weight	319.4
Formula	C21H21NO2
CAS No.	775294-71-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (313.09 mM)

References and Literature

1. Fu ZG, et al. A novel small-molecule compound targeting CD147 inhibits the motility and invasion of hepatocellular carcinoma cells. Oncotarget. 2016 Feb 23;7(8):9429-47. 2. Spinello I, et al. The small-molecule compound AC-73 targeting CD147 inhibits leukemic cell proliferation, induces autophagy and increases the chemotherapeutic sensitivity of acute myeloid leukemia cells. Haematologica. 2019 May;104(5):973-985.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Autophagy Compound Library Bioactive Compound Library Bioactive Compounds Library Max

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Keywords

AC-73 775294-71-8 Autophagy AC 73 AC73 inhibitor inhibit

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