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Pertuzumab

Catalog No. T9909 CAS 380610-27-5

Synonyms: Pertuzumab (anti-HER2), anti-HER2, Omnitarg, 2C4

Pertuzumab anti-HER2) a humanized monoclonal antibody and the first in the class of agents called the HER2 dimerization inhibitors impairs the ability of HER2 to bind to other members of the HER family.

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Pertuzumab, CAS 380610-27-5

Pack Size	Availability	Price/USD	Quantity
5 mg	Inquiry	558.00

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Purity 98.3%

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	Pertuzumab anti-HER2) a humanized monoclonal antibody and the first in the class of agents called the HER2 dimerization inhibitors impairs the ability of HER2 to bind to other members of the HER family.
Targets&IC50	HER2
Cell Research	Objective: Antibody-dependent cellular cytotoxicity (ADCC) Concentrations: 2.5 μg/mL Incubation Time: -- Method: A standard 5 h chromium (51Cr) release assay was performed to measure the cytotoxic reactivity of peripheral blood lymphocytes (PBLs) from several healthy donors in combination with trastuzumab and/or pertuzumab against USPC target cell lines. Cell lines: peripheral blood lymphocytes (PBLs), USPC cell lines (Uterine cancer cell)
Animal Research	Objective: In vivo tumor growth inhibition studies Formulation: saline Dosages: 20 mg/kg, 40 mg/kg and 80 mg/kg

Synonyms	Pertuzumab (anti-HER2) , anti-HER2 , Omnitarg , 2C4
Purity	98.3%
Molecular Weight	N/A
CAS No.	380610-27-5

Storage

Store the unopened solution at -20℃, and store it at 4℃ after melting to avoid repeated freeze-thaw

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature

1. Sakai K, et al. Pertuzumab, a novel HER dimerization inhibitor, inhibits the growth of human lung cancer cells mediated by the HER3 signaling pathway. Cancer Sci.2007 Sep;98(9):1498-503. 2. Yamashita-Kashima Y, et al. Pertuzumab in combination with trastuzumab shows significantly enhanced antitumor activity in HER2-positive human gastric cancer xenograft models. Clin Cancer Res. 2011 Aug 1;17(15):5060-70. 3. Franklin MC, et al. Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex. Cancer Cell. 2004 Apr;5(4):317-28.

Dose Conversion

You can also refer to dose conversion for different animals. More

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.