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Firsocostat

Firsocostat
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Purity:99.01%
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Firsocostat

Catalog No. T7184Cas No. 1434635-54-7
Firsocostat (GS-0976) is an inhibitor of acetyl-CoA carboxylase (ACC) dimerization that inhibits human ACC1 and ACC2 activity (IC50s of 2.1 and 6.1 nM, respectively)
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Pack SizePriceAvailabilityQuantity
1 mg$88In Stock
2 mg$129In Stock
5 mg$222In Stock
10 mg$372In Stock
25 mg$537In Stock
50 mg$690In Stock
100 mg$955In Stock
500 mg$1,890In Stock
1 mL x 10 mM (in DMSO)$279In Stock
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Product Introduction

Bioactivity
Description
Firsocostat (GS-0976) is an inhibitor of acetyl-CoA carboxylase (ACC) dimerization that inhibits human ACC1 and ACC2 activity (IC50s of 2.1 and 6.1 nM, respectively)
In vitro
ND-630 inhibited hACC1 with an IC50 of 2.1 ± 0.2 nM and hACC2 with an IC50 of 6.1 ± 0.8 nM .?Inhibition was reversible and highly specific for ACC, as evidenced by the absence of an effect of ND-630 on the activity of 101 enzymes, receptors, growth factors, transporters, and ion channels of the Ricerca DrugMatrix Panel at 10 μM .?In addition, because the ACC dimerization site is not conserved among the mammalian carboxylases , ND-630 lacks the ability to inhibit any of these mechanistically related enzymes and therefore exhibits absolute specificity for ACC inhibition relative to other mammalian carboxylases.
In vivo
ND-630 reduces hepatic steatosis in a rat model of diet-induced obesity and in Zucker diabetic rats. It also improves insulin secretion stimulated by glucose and reduces hemoglobin A1c levels by 0.9% in Zucker diabetic rats.
AliasND-630, NDI-010976, GS-0976
Chemical Properties
Molecular Weight569.63
FormulaC28H31N3O8S
Cas No.1434635-54-7
Storage & Solubility Information
Storage Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 60 mg/mL (105.33 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.7555 mL8.7776 mL17.5553 mL87.7763 mL
5 mM0.3511 mL1.7555 mL3.5111 mL17.5553 mL
10 mM0.1756 mL0.8778 mL1.7555 mL8.7776 mL
20 mM0.0878 mL0.4389 mL0.8778 mL4.3888 mL
50 mM0.0351 mL0.1756 mL0.3511 mL1.7555 mL
100 mM0.0176 mL0.0878 mL0.1756 mL0.8778 mL

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