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Pembrolizumab

Catalog No. T9908 CAS 1374853-91-4

Synonyms: Pembrolizumab (anti-PD-1), anti-PD-1, MK-3475, lambrolizumab

Pembrolizumab is a humanized monoclonal antibody and the first in the class of agents called the HER2 dimerization inhibitors impairs the ability of HER2 to bind to other members of the HER family.

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Pembrolizumab, CAS 1374853-91-4

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5 mg	In stock	542.00

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Purity 98.1%

COA

Purity 99.21%

HPLC COA

Datasheet SDS

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Pembrolizumab is a humanized monoclonal antibody and the first in the class of agents called the HER2 dimerization inhibitors impairs the ability of HER2 to bind to other members of the HER family.
Targets&IC50	PD-1
Cell Research	Objective: To examine the effect of high-dose steroid therapy on lymphocyte proliferation/functionality after stimulation with anti-CD3 in the presence of pembrolizumab Concentrations: 5 μg/mL Method: Isolated PBMCs were pre-treated with prednisone (1 nM - 1 mM) before anti-CD3 stimulation. Anti-CD3-stimulated cells were then incubated with pembrolizumab and their proliferative capacity and IL-2 secretion ability were measured by carboxyfluorescein succinimidyl ester (CFSE) staining and ELISA. Cell lines: Human PBMCs
Animal Research	Objective: To evaluate the pharmacokinetics and biodistribution of 89Zr-labeled Pembrolizumab

Synonyms	Pembrolizumab (anti-PD-1) , anti-PD-1 , MK-3475 , lambrolizumab
Purity	98.1%
Molecular Weight	149000
CAS No.	1374853-91-4

Storage

Store the unopened solution at -20℃, and store it at 4℃ after melting to avoid repeated freeze-thaw

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature

1. Khoja L, et al. Pembrolizumab. J Immunother Cancer. 2015 Aug 18;3:36. 2. Garon EB, et al. Pembrolizumab for the treatment of non-small-cell lung cancer. N Engl J Med. 2015 May 21;372(21):2018-28.

Related Products

Related compounds with same targets

Pembrolizumab Nivolumab Avelumab Atezolizumab PDL-1 cpd 10 BMS-1001 Phellodendrine chloride BMS1166

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

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