cell-mediated — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T10549	Bisindolylmaleimide VIII acetate	Ro 31-7549 acetate,Bis VIII acetate	Apoptosis , PKC
	Bisindolylmaleimide VIII acetate (Ro 31-7549 acetate) is a potent and selective PKC inhibitor (IC50: 158 nM for rat brain PKC). It has IC50s of 53, 195, 163, 213, and 175 nM for PKC-α, PKC-βI, PKC-βII, PKC-γ, PKC-ε, resp...		Apoptosis , PKC
T40236	ART812	ART812	DNA/RNA Synthesis
	ART812 is an orally active inhibitor of DNA polymerase Polθ, possessing an IC50 value of 7.6 nM. Additionally, ART812 exhibits a cell-based microhomology-mediated end joining (MMEJ) IC50 value of 240 nM.		DNA/RNA Synthesis
T24706	RBC10	RBC 10,RBC-10	GTPase
	RBC10 inhibits the binding of Ral to its effector RALBP1, as well as inhibiting Ral-mediated cell spreading of murine embryonic fibroblasts and anchorage-independent growth of human cancer cell lines.		GTPase
T83643	4-Methylumbelliferyl heptanoate	4-Methylumbelliferyl enanthate
	4-Methylumbelliferyl heptanoate (4-Methylumbelliferyl enanthate) is a lipase fluorescent substrate that detects cell-mediated cytotoxicity and cell proliferation.
T0927	Butylparaben	Butyl 4-hydroxybenzoate,Butyl parahydroxybenzoate	Endogenous Metabolite , Antibacterial , Antibiotic
	Butylparaben (Butyl 4-hydroxybenzoate) is a standardized chemical allergen, increasing histamine release, and cell-mediated immunity.		Endogenous Metabolite , Antibacterial , Antibiotic
T7317	CU-CPT-9a		TLR
	CU-CPT-9a is a potent TLR8 inhibitor (IC50 : 0.5 nM), that suppresses TLR8-mediated proinflammatory signaling in various cell lines and human primary cells-		TLR
TP1015	NFAT Inhibitor	VIVIT peptide	Others
	NFAT Inhibitor (VIVIT peptide) is a cell-permeable compound that selectively inhibits calcineurin-mediated dephosphorylation of NFAT.		Others
T9903	Avelumab		PD-1/PD-L1
	Avelumab is a fully human IgG1 anti-PD-L1 monoclonal antibody. Avelumab shows potential antibody-dependent cell-mediated cytotoxicity.		PD-1/PD-L1
T19826	Rabeprazole	LY307640	Potassium Channel , STAT
	Rabeprazole (LY307640) is an H+/K+-ATPase inhibitor that inhibits cell proliferation in gastric epithelial cells by targeting STAT3-mediated glycolysis and can be used in the study of gastric ulcers.		Potassium Channel , STAT
T4163	Reparixin	DF 1681Y,Repertaxin	CXCR
	Reparixin (Repertaxin) is a potent inhibitor of both CXCL8 receptors CXCR1/2, it inhibits weakly CXCR2-mediated cell migration (IC50=100 nM), whereas it strongly blocks CXCR1-mediated chemotaxis (IC50=1 nM).		CXCR
T11600	IBR2	Isoquinoline	DNA/RNA Synthesis
	IBR2 (Isoquinoline) is a potent and specific RAD51 inhibitor known for its ability to suppress RAD51-mediated DNA double-strand break repair. By interfering with RAD51 multimerization, accelerating proteasome-mediated RA...		DNA/RNA Synthesis
T3059	ALK-IN-1	AP26113,Brigatinib,AP26113-analog	EGFR , IGF-1R , ALK
	ALK-IN-1 (AP26113) is a potent ALK inhibitor with IC50 of 0.62 nM in a cell-free assay, demonstrated ability overcome Crizotinib resistance mediated by a L1196M mutation. Phase 2.		EGFR , IGF-1R , ALK
T10565	BMS-1001 hydrochloride		PD-1/PD-L1
	BMS-1001 hydrochloride is an orally active inhibitor of human PD-1/PD-L1 immune checkpoint with low-toxicity in cells.BMS-1001 alleviates the inhibitory effect of the soluble PD-L1 on the T-cell receptor-mediated activat...		PD-1/PD-L1
T22889	KF38789	KF 38789	Others
	KF38789 is a selective inhibitor of P-selectin-mediated cell adhesion and P-selectin immunoglobulin G chimeric protein.		Others
T13932	TLR1		Others , MyD88
	TLR1 is a cell-penetrating Toll/IL-1 receptor/resistance (TIR) domain/BB-Loop mimic and inhibits IL-1 receptor-mediated responses.		Others , MyD88
T7323	BCI-215		Phosphatase
	BCI-215 causes selective cancer cell cytotoxicity in part through non-redox-mediated activation of MAPK signaling		Phosphatase
TN1933	Mitraphylline		IL Receptor , TNF , NF-κB
	Mitraphylline has antiproliferative effects on human glioma and neuroblastoma cell lines. It also has anti-inflammatory activity, it inhibits lipopolysaccharide-mediated activation of primary human neutrophils.		IL Receptor , TNF , NF-κB
T77011	Flanvotumab	20D7S,IMC 20D7S	Tyrosinase
	Flanvotumab (IMC-20D7S) is a humanized monoclonal antibody directed against tyrosinase-related protein (TYRP1).Flanvotumab exhibits potent antitumor activity and acts through natural killer-mediated and antibody-dependen...		Tyrosinase
T1297	Eugenol	4-Allylguaiacol,Allylguaiacol,4-Allyl-2-methoxyphenol,Eugenic acid	Apoptosis , Ferroptosis , Reactive Oxygen Species , Antibacterial , Parasite
	Eugenol (Allylguaiacol) is a Standardized Chemical Allergen. The physiologic effect of eugenol is by means of Increased Histamine Release and Cell-mediated Immunity.
T7032	Eupatorin		Others , P450
	Eupatorin has antiproliferative and antiangiogenic effects. Eupatorin has antiproliferative and cytostatic effects on MDA-MB-468 human breast cancer cells due to CYP1-mediated metabolism. Eupatorin-induced cell death is ...		Others , P450