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Rabeprazole

Catalog No. T19826 CAS 117976-89-3

Synonyms: LY307640

Rabeprazole (LY307640) is an H+/K+-ATPase inhibitor that inhibits cell proliferation in gastric epithelial cells by targeting STAT3-mediated glycolysis and can be used in the study of gastric ulcers.

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Rabeprazole, CAS 117976-89-3

Pack Size	Availability	Price/USD
5 mg	In stock	$ 31.00
10 mg	In stock	$ 48.00
25 mg	In stock	$ 77.00
50 mg	In stock	$ 113.00

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Purity: 97.06%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Rabeprazole (LY307640) is an H+/K+-ATPase inhibitor that inhibits cell proliferation in gastric epithelial cells by targeting STAT3-mediated glycolysis and can be used in the study of gastric ulcers.
Targets&IC50	UNH:0.3 μM (IC50)
In vitro	Rabeprazole was administered to three gastric cancer cell lines, KATO III, MKN-28, and MKN-45, at a dosage of 0.2 mM under acidic conditions for 16 hours. The results showed that rabeprazole exerted a strong inhibitory effect on the proliferation of gastric cancer cells[2].
In vivo	The results of rabeprazole (10 mg/kg; oral administration; every 48 hours for 18 weeks) showed significantly lower serum calcium levels compared to the vehicle-treated group in Swiss albino mice[3].

Synonyms	LY307640
Molecular Weight	359.44
Formula	C18H21N3O3S
CAS No.	117976-89-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 5 mg/mL (13.91 mM), Sonication is recommended.

References and Literature

1. Tara A Shea, et al. Identification of Proton-Pump Inhibitor Drugs That Inhibit Trichomonas Vaginalis Uridine Nucleoside Ribohydrolase. Bioorg Med Chem Lett. 2014 Feb 15;24(4):1080-4. 2. Mengli Gu, et al. Rabeprazole Exhibits Antiproliferative Effects on Human Gastric Cancer Cell Lines. Oncol Lett. 2014 Oct;8(4):1739-1744. 3. Aly A M Shaalan, et al. Supplement With Calcium or Alendronate Suppresses Osteopenia Due to Long Term Rabeprazole Treatment in Female Mice: Influence on Bone TRAP and Osteopontin Levels. Front Pharmacol. 2020 May 13;11:583. 4. Kinoshita Y, Kato M, Fujishiro M, Masuyama H, Nakata R, Abe H, Kumagai S, Fukushima Y, Okubo Y, Hojo S, Kusano M. Efficacy and safety of twice-daily rabeprazole maintenance therapy for patients with reflux esophagitis refractory to standard once-daily proton pump inhibitor: the Japan-based EXTEND study. J Gastroenterol. 2017 Nov 29. doi: 10.1007/s00535-017-1417-z. [Epub ahead of print] PubMed PMID: 29188387.

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Keywords

Rabeprazole 117976-89-3 JAK/STAT signaling Membrane transporter/Ion channel Stem Cells Potassium Channel STAT LY307640 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.