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ALK-IN-1

Catalog No. T3059 CAS 1197958-12-5

Synonyms: AP26113, Brigatinib, AP26113-analog

ALK-IN-1 (AP26113) is a potent ALK inhibitor with IC50 of 0.62 nM in a cell-free assay, demonstrated ability overcome Crizotinib resistance mediated by a L1196M mutation. Phase 2.

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ALK-IN-1, CAS 1197958-12-5

Pack Size	Availability	Price/USD
2 mg	In stock	$ 30.00
5 mg	In stock	$ 47.00
10 mg	In stock	$ 67.00
25 mg	In stock	$ 97.00
50 mg	In stock	$ 147.00
100 mg	In stock	$ 247.00
200 mg	In stock	$ 368.00
500 mg	In stock	$ 596.00
1 mL * 10 mM (in DMSO)	In stock	$ 55.00

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Purity: 100%

Purity: 97.66%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	ALK-IN-1 (AP26113) is a potent ALK inhibitor with IC50 of 0.62 nM in a cell-free assay, demonstrated ability overcome Crizotinib resistance mediated by a L1196M mutation. Phase 2.
Targets&IC50	ALK:0.62 nM
Cell Research	Three-day cell viability assays are carried out by plating 2,000, 1,500 and 2,000 cells per well of Ba/F3, PC9 or MGH121, respectively, into black transparent-bottom 96-well plates. On the same day for Ba/F3 cells and the following day for PC9 and MGH121 cells, the cells are treated with each TKI across a 10-dose range from 0.3 nM to 10 μM. After 72 h of drug treatment, cell viability is measured using the CellTiter-Glo assay. (Only for Reference)

Synonyms	AP26113, Brigatinib, AP26113-analog
Molecular Weight	529.01
Formula	C26H34ClN6O2P
CAS No.	1197958-12-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 98 mg/mL (185.3 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 42 mg/mL (79.4 mM)

References and Literature

1. Wei-Sheng Huang, et al. J Med Chem, 2016, 59(10):4948-4964. 2. Uchibori K, et al. Nat Commun. 2017, 8:14768.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Approved Drug Library Anti-Cancer Drug Library Kinase Inhibitor Library Inhibitor Library Tyrosine Kinase Inhibitor Library Drug Repurposing Compound Library FDA-Approved Kinase Inhibitor Library Anti-Cancer Active Compound Library Human Metabolite Library Anti-Ovarian Cancer Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

ALK-IN-1 1197958-12-5 Angiogenesis JAK/STAT signaling Tyrosine Kinase/Adaptors EGFR IGF-1R ALK Anaplastic lymphoma kinase (ALK) AP26113 AP 26113 Cluster of differentiation 246 inhibit CD246 Anaplastic lymphoma kinase Brigatinib AP-26113 AP26113-analog ALK IN 1 ALK tyrosine kinase receptor ALKIN1 Inhibitor inhibitor

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