Store the unopened solution at -20℃, and store it at 4℃ after melting to avoid repeated freeze-thaw
Avelumab is a fully human IgG1 anti-PD-L1 monoclonal antibody with potential antibody-dependent cell-mediated cytotoxicity.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | 490.00 | |
5 mg | Inquiry | 1584.00 | |
10 mg | Inquiry | 2556.00 |
Description | Avelumab is a fully human IgG1 anti-PD-L1 monoclonal antibody with potential antibody-dependent cell-mediated cytotoxicity. |
Targets&IC50 | PD-L1 |
Cell Research |
To examine the relationship between a cancer stem cell (CSC) subpopulation and antibody-dependent cell-mediated cytotoxicity (ADCC) activity, UM-Chor1 cells are left untreated or treated with 50 ng/mL of IFN-γ for 24 h. Cells are then plated as targets at 50,000 cells/well in 6-well round-bottom culture plates and incubated with 2 μg/mL of Avelumab at room temperature for 30 min. NK cells are added at 2500,000 cells/well at an effector-to-target (E:T) ratio of 50:1. After 4 h, tumor cells are harvested and stained with antibodies for flow cytometry[1].
Cell lines: JHC7 cells
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Animal Research |
Female C57BL/6 mice are used in this study. Subcutaneous tumor injections are carried out by inoculating C57BL/6 mice with 1×105 MB49 parental cells on the right shaved flank. Tumor growth is measured with calipers and 8 days post-inoculation mice are assigned to treatment groups. Tumor-bearing mice are treated with Avelumab (400 μg per 100 μL) and injected i.p. three times, 3 days apart. Since Avelumab is a human IgG1, three injections have to be compressed within a 7 to 9 day window (i.e., days 9, 12, and 15 post-tumor inoculation) to avoid the onset of neutralizing mouse anti-human Ig[3].
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Synonyms | Avelumab (anti- PD-L1) , anti- PD-L1 , MSB 0010718C , MSB0010718C |
Purity | 99.2% |
Molecular Weight | 147000 |
CAS No. | 1537032-82-8 |
Store the unopened solution at -20℃, and store it at 4℃ after melting to avoid repeated freeze-thaw
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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