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Apoptosis PD-1/PD-L1 Avelumab

Avelumab

Catalog No. T9903   CAS 1537032-82-8
Synonyms: Avelumab (anti- PD-L1), anti- PD-L1, MSB 0010718C, MSB0010718C

Avelumab is a fully human IgG1 anti-PD-L1 monoclonal antibody with potential antibody-dependent cell-mediated cytotoxicity.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
Avelumab, CAS 1537032-82-8
Pack Size Availability Price/USD Quantity
1 mg In stock 490.00
5 mg Inquiry 1584.00
10 mg Inquiry 2556.00
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Purity 99.2%
Biological Description
Chemical Properties
Storage & Solubility Information
Description Avelumab is a fully human IgG1 anti-PD-L1 monoclonal antibody with potential antibody-dependent cell-mediated cytotoxicity.
Targets&IC50 PD-L1
Cell Research
To examine the relationship between a cancer stem cell (CSC) subpopulation and antibody-dependent cell-mediated cytotoxicity (ADCC) activity, UM-Chor1 cells are left untreated or treated with 50 ng/mL of IFN-γ for 24 h. Cells are then plated as targets at 50,000 cells/well in 6-well round-bottom culture plates and incubated with 2 μg/mL of Avelumab at room temperature for 30 min. NK cells are added at 2500,000 cells/well at an effector-to-target (E:T) ratio of 50:1. After 4 h, tumor cells are harvested and stained with antibodies for flow cytometry[1].
Cell lines: JHC7 cells
Animal Research
Female C57BL/6 mice are used in this study. Subcutaneous tumor injections are carried out by inoculating C57BL/6 mice with 1×105 MB49 parental cells on the right shaved flank. Tumor growth is measured with calipers and 8 days post-inoculation mice are assigned to treatment groups. Tumor-bearing mice are treated with Avelumab (400 μg per 100 μL) and injected i.p. three times, 3 days apart. Since Avelumab is a human IgG1, three injections have to be compressed within a 7 to 9 day window (i.e., days 9, 12, and 15 post-tumor inoculation) to avoid the onset of neutralizing mouse anti-human Ig[3].
Synonyms Avelumab (anti- PD-L1) , anti- PD-L1 , MSB 0010718C , MSB0010718C
Purity 99.2%
Molecular Weight 147000
CAS No. 1537032-82-8

Storage

Store the unopened solution at -20℃, and store it at 4℃ after melting to avoid repeated freeze-thaw

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Fujii R, et al. Enhanced killing of chordoma cells by antibody-dependent cell-mediated cytotoxicity employing the novel anti-PD-L1 antibody avelumab. Oncotarget. 2016 Jun 7;7(23):33498-511. 2. Grenga I, et al. A fully human IgG1 anti-PD-L1 MAb in an in vitro assay enhances antigen-specific T-cell responses. Clin Transl Immunology. 2016 May 20;5(5):e83. 3. Vandeveer AJ, et al. Systemic Immunotherapy of Non-Muscle Invasive Mouse Bladder Cancer with Avelumab, an Anti-PD-L1 Immune Checkpoint Inhibitor. Cancer Immunol Res. 2016 May;4(5):452-62.

Related Products

Related compounds with same targets
Pembrolizumab Nivolumab Avelumab Atezolizumab PDL-1 cpd 10 BMS-1001 Phellodendrine chloride BMS1166

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