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Avelumab

Catalog No. T9903   CAS 1537032-82-8

Avelumab is a fully human IgG1 anti-PD-L1 monoclonal antibody. Avelumab shows potential antibody-dependent cell-mediated cytotoxicity.

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Avelumab Chemical Structure
Avelumab, CAS 1537032-82-8
Pack Size Availability Price/USD Quantity
1 mg In stock $ 289.00
5 mg In stock $ 696.00
10 mg In stock $ 987.00
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AntibodyUnit: 4.5 mg/mL
Purity: 98.30%
AntibodyUnit: 7.75 mg/mL
Purity: 95.00%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Avelumab is a fully human IgG1 anti-PD-L1 monoclonal antibody. Avelumab shows potential antibody-dependent cell-mediated cytotoxicity.
Animal Research Female C57BL/6 mice are used in this study. Subcutaneous tumor injections are carried out by inoculating C57BL/6 mice with 1×105 MB49 parental cells on the right shaved flank. Tumor growth is measured with calipers and 8 days post-inoculation mice are assigned to treatment groups. Tumor-bearing mice are treated with Avelumab (400 μg per 100 μL) and injected i.p. three times, 3 days apart. Since Avelumab is a human IgG1, three injections have to be compressed within a 7 to 9 day window (i.e., days 9, 12, and 15 post-tumor inoculation) to avoid the onset of neutralizing mouse anti-human Ig[3].
Molecular Weight 147 kDa
CAS No. 1537032-82-8

Storage

store at low temperature

store at -20 ℃

TargetMolReferences and Literature

1. Fujii R, et al. Enhanced killing of chordoma cells by antibody-dependent cell-mediated cytotoxicity employing the novel anti-PD-L1 antibody avelumab. Oncotarget. 2016 Jun 7;7(23):33498-511. 2. Grenga I, et al. A fully human IgG1 anti-PD-L1 MAb in an in vitro assay enhances antigen-specific T-cell responses. Clin Transl Immunology. 2016 May 20;5(5):e83. 3. Vandeveer AJ, et al. Systemic Immunotherapy of Non-Muscle Invasive Mouse Bladder Cancer with Avelumab, an Anti-PD-L1 Immune Checkpoint Inhibitor. Cancer Immunol Res. 2016 May;4(5):452-62.

Related Products

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PD-1-IN-17 PD-L1-IN-3 SWS1 LP23 Human membrane-bound PD-L1 polypeptide Tomivosertib PD-1/PD-L1-IN-33 PD-1-IN-22

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Keywords

Avelumab 1537032-82-8 Apoptosis Cell Cycle/Checkpoint Immunology/Inflammation PD-1/PD-L1 Inhibitor inhibit MSB0010718C MSB 0010718C inhibitor

 

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