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KF38789

Catalog No. T22889 CAS 257292-29-8

Synonyms: KF 38789

KF38789 is a selective inhibitor of P-selectin-mediated cell adhesion and P-selectin immunoglobulin G chimeric protein.

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KF38789, CAS 257292-29-8

Pack Size	Availability	Price/USD
1 mg	In stock	$ 53.00
5 mg	In stock	$ 123.00
10 mg	In stock	$ 197.00
25 mg	In stock	$ 376.00
50 mg	In stock	$ 559.00

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Purity: 98.13%

Purity: 97.29%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	KF38789 is a selective inhibitor of P-selectin-mediated cell adhesion and P-selectin immunoglobulin G chimeric protein.
Targets&IC50	P-selectin-Ig:1.97 microM
In vitro	KF 38789, inhibited the binding of U937 cells to immobilized P-selectin immunoglobulin G chimeric protein (P-selectin-Ig) with an IC50 value of 1.97 microM. Cell adhesion to both E-selectin-Ig and L-selectin-Ig were not affected even by 100 microM of KF 38789. Moreover, KF 38789 inhibited P-selectin-induced superoxide production from human polymorphonuclear cells. Intravenously injected KF 38789 significantly inhibited the TG-induced accumulation of leukocytes in the mouse peritoneal cavity (p<0.01)[1].
In vivo	KF 38789 significantly reduced mechanical allodynia in the facial carrageenan-injected mice[2].

Synonyms	KF 38789
Molecular Weight	375.44
Formula	C19H21NO5S
CAS No.	257292-29-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: < 30 mg/mL (79.91 mM)

References and Literature

1. S Ohta, et al. Inhibition of P-selectin specific cell adhesion by a low molecular weight, non-carbohydrate compound, KF38789. Inflamm Res. 2001 Nov;50(11):544-51. 2. Kay-Wee Poh, et al. Global gene expression analysis in the mouse brainstem after hyperalgesia induced by facial carrageenan injection--evidence for a form of neurovascular coupling? Pain. 2009 Mar;142(1-2):133-41. 3. Peter J Gillies, et al. Demonstration of P-selectin expression and potential function in human corneal epithelial cells. Exp Eye Res. 2018 Nov;176:196-206.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

KF38789 257292-29-8 Others inhibit Inhibitor PSGL-1 Cell adhesion P-selectin Inhibitor KF-38789 KF 38789 Inflammation inhibitor

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