anti-fibrosis — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T20626	Esomeprazole		Proton pump , Cysteine Protease
	Esomeprazole is the S-isomer of omeprazole, inhibits the lysosomal cysteine protease legumain to prevent cancer metastasis. Esomeprazole is a proton pump inhibitors (PPI).		Proton pump , Cysteine Protease
T83064	Anti-hepatic fibrosis agent 2
	Compound 6k, also known as Anti-hepatic fibrosis agent 2, is an orally active inhibitor of the COL1A1 enzyme and exerts anti-fibrogenic effects by targeting the Ewing sarcoma breakpoint region 1 (EWSR1)[1].
T6569	Mimosine	Leucenine,NSC 69188,Leucenol,L-Mimosine	Others
	L-Mimosine (Leucenol) is an antineoplastic alanine-substituted pyridine derivative isolated from Leucena glauca and acts as an iron chelator.		Others
T9195	SHR0302	ARQ252	Apoptosis , JAK
	SHR0302 (ARQ252) is a JAK inhibitor that binds JAK1 with stronger affinity than others (Selectivity for JAK1 is more than 10 times for JAK2, 77 times for JAK3, 420 times for Tyk2).		Apoptosis , JAK
T6540	Ibuprofen Lysine	Neoprofen	COX
	Ibuprofen Lysine (Neoprofen) is a non-steroidal anti-inflammatory drug.		COX
T1394	Ibuprofen	Brufen,(±)-Ibuprofe,Motrin,Advil	COX
	Ibuprofen (Advil) is a propionic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic effects. Ibuprofen inhibits the activity of cyclo-oxygenase I and II, resu...		COX
T2686L	Esomeprazole Sodium	(S)-Omeprazole sodium	ATPase , Proton pump
	Esomeprazole Sodium ((S)-Omeprazole sodium) is the S-isomer of omeprazole with selective and irreversible proton pump inhibitor activity.Esomeprazole acts as an exosome inhibitor by blocking the exosome release via the i...		ATPase , Proton pump
T2486	IOWH-032	IOWH032,IOWH 032	CFTR , Autophagy
	IOWH-032 (IOWH032) , a synthetic CFTR inhibitor, has been investigated for the treatment of cholera, diarrhea, and secretory diarrhea.		CFTR , Autophagy
T4503	Talniflumate	Somalgen	Chloride channel , COX , N-Acetylglucosaminyltransferase , Anion Exchanger
	Talniflumate (Somalgen) is a calcium-activated chloride channel (hCLCA1/mCLCA3) blocker that reduces mucin synthesis and releases in animal models and cell culture. It possesses anti-inflammatory actions via inhibition o...
T2663	GTS-21 dihydrochloride	GTS 21 dihydrochloride,DMXB-A,DMBX-anabaseine	5-HT Receptor , AChR
	GTS-21 dihydrochloride (DMBX-anabaseine) is a nAChRs agonist. nAChRs are neuron receptor proteins that activated by the binding of the neurotransmitter ACh.		5-HT Receptor , AChR
T10409	ATX inhibitor 5		PDE
	ATX inhibitor 5 is a potent and orally active autotaxin (ATX) inhibitor (IC50 : 15.3 nM) that reduces the level of CCl4-induced hepatic fibrosis and has anti-hepatic fibrosis effects,.		PDE
T14076	A 839977	A839977,A-839977	P2X Receptor , Calcium Channel
	A 839977 is a selective P2X7 receptor antagonist with anti-inflammatory and analgesic activity that inhibits BzATP-induced calcium efflux from the P2X7 receptor for the study of renal fibrosis.		P2X Receptor , Calcium Channel
T15647	Tipelukast	MN 001,KCA 757	Leukotriene Receptor
	Tipelukast (KCA 757) is a novel orally available leukotriene receptor antagonist with anti-inflammatory activity that reduces fibrosis and down-regulates TIMP-1, type 1 collagen.Tipelukast is used in the study of asthma.		Leukotriene Receptor
T4S1102	Liensinine diperchlorate	Liensinine-Perchlorate	Mitophagy , Others , Autophagy
	Liensinine Diperchlorate is an isoquinoline alkaloid extracted from the embryonic seeds of the sacred lotus. It inhibits late autophagy by blocking autophagosome-lysosome fusion and exhibits biological activities such as...		Mitophagy , Others , Autophagy
T11411	GLPG1205		GPR , Others
	GLPG1205 is a potent, orally active GPR84 (G protein-coupled receptor) antagonist with anti-inflammatory activity. GLPG1205 shows good PK/PD characteristics and can be used to study pulmonary fibrosis.		GPR , Others
TN1936	Mogroside III-E		IL Receptor , TNF , TLR
	Mogroside III-E is a cucurbitane-type compound isolated from Siraitia grosvenorii, has anti-inflammatory activity, it attenuates LPS-induced acute lung injury in mice partly through regulation of the TLR4/MAPK/NF-κB axis...		IL Receptor , TNF , TLR
T72918	JNJ-49095397	RV568	Antiviral , p38 MAPK
	JNJ-49095397 (RV568) is a selective p38 MAPK-α and p38 MAPK--γ kinase inhibitor with anti-inflammatory activity and potential antiviral activity for chronic obstructive pulmonary disease (COPD), cystic fibrosis, and resp...		Antiviral , p38 MAPK
T76956	Vixarelimab	RG-6536,RO-7622888,KPL-716	Interleukin
	Vixarelimab (KPL-716) is a human anti-oncostatin M (OSM) monoclonal antibody with affinity for the beta chain of the OSM receptor and inhibition of IL-31 and OSM signaling.Vixarelimab can be used to study severe nodular ...		Interleukin
T6S1049	Wilforine		ATPase
	Wilforine is a sesquiterpene pyridine alkaloid; important bioactive compound in T. wilfordii plants, and is effective in treating idiopathic pulmonary fibrosis. Wilforine has anti-inflammatory effect, which might be medi...		ATPase
T3795	Corilagin		Apoptosis , TLR , Reverse Transcriptase , Antibacterial , Autophagy
	Corilagin has anti-inflammatory activity. Corilagin has a significant antitumour potential and lower toxicity in normal cells in vitro.Corilagin can enhance the cytotoxicity of both cisplatin and doxorubicin on the Hep3B...