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Mimosine

Catalog No. T6569   CAS 500-44-7
Synonyms: Leucenine, NSC 69188, Leucenol, L-Mimosine

L-Mimosine (Leucenol) is an antineoplastic alanine-substituted pyridine derivative isolated from Leucena glauca and acts as an iron chelator.

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Mimosine Chemical Structure
Mimosine, CAS 500-44-7
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Purity: 99.84%
Purity: 99.48%
Purity: 99.2%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description L-Mimosine (Leucenol) is an antineoplastic alanine-substituted pyridine derivative isolated from Leucena glauca and acts as an iron chelator.
In vitro L-Mimosine arrests the cell cycle at the G1 phase in PC-3 cells and at the S phase in LNCaP cells, thus attenuating cell proliferation. [1] L-Mimosine, as a prolyl hydroxylase (PHD) inhibitor, stimulates VEGF production, and increases their proangiogenic capacity in dental pulp-derived cells. [2]
In vivo L-mimosine (50 mg/kg i.p.) substantially upregulates HIF-1alpha expression in the kidneys, and remarkably enhances the natriuretic response to renal perfusion pressure in Sprague-Dawley rats. [3]
Cell Research Cell proliferation in response to L-mimosine is measured using a [3H]thymidine incorporation assay. In this assay, 1 × 104 cells are cultured in each well of a 12-well plate in RPMI-1640 medium with 10% FCS and different concentrations (0–800 μM) of L-mimosine. After the required incubation periods (24 and 48 h), 0.5 μCi/ml of [3H]thymidine is added to each well of the 12-well plate. The cells are then incubated at 37°C in a humidified 5% CO2 atmosphere for 4 h. Cells are then washed twice with cold phosphate-buffered saline (PBS) and then with cold 5% trichloroacetic acid. Cells are lysed by adding 0.5 ml of 0.5 N NaOH. Then 400 μl of the solubilized cell solution are mixed with 4 ml of scintillation cocktail and counted in a liquid scintillation analyzer . Each sample was tested in quadruplicate.(Only for Reference)
Source
Synonyms Leucenine, NSC 69188, Leucenol, L-Mimosine
Molecular Weight 198.18
Formula C8H10N2O4
CAS No. 500-44-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 0.01 mg/mL (0.05 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

TargetMolReferences and Literature

1. Chung LC, et al. Am J Physiol Cell Physiol. 2012, 302(4), C676-685. 2. Müller HD, et al. J Endod. 2012, 38(11), 1498-1503.. 3. Li N, et al. Am J Physiol Renal Physiol. 2007, 292(1), F207-216.

Related compound libraries

This product is contained In the following compound libraries:
Natural Product Library for HTS Traditional Chinese Medicine Monomer Library Natural Product Library RO5 Drug-like Natural Product Library Ferroptosis Compound Library Bioactive Compounds Library Max NO PAINS Compound Library Toxic Compound Library Mitochondria-Targeted Compound Library Bioactive Compound Library

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Keywords

Mimosine 500-44-7 Others anti-fibrosis Fe(III) NSC-69188 Anti-cancer herbicida inhibit Leucenine NSC 69188 Apoptosis iron-binding NSC69188 insecticidal chelator antioxidant Leucenol antiinflammation Inhibitor anti-influenza L-Mimosine anti-virus inhibitor

 

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