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ATX inhibitor 5

Name: ATX inhibitor 5
Brand: TargetMol
SKU: T10409
Price: 41 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T10409Cas No. 2402772-45-4

ATX inhibitor 5 is a potent and orally active autotaxin (ATX) inhibitor (IC50: 15.3 nM) that reduces CCl4-induced hepatic fibrosis and exhibits anti-hepatic fibrosis effects.

ATX inhibitor 5

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Purity: 99.73%

Catalog No. T10409Cas No. 2402772-45-4

ATX inhibitor 5 is a potent and orally active autotaxin (ATX) inhibitor (IC50: 15.3 nM) that reduces CCl4-induced hepatic fibrosis and exhibits anti-hepatic fibrosis effects.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$41	In Stock	In Stock
5 mg	$100	In Stock	In Stock
10 mg	$161	In Stock	In Stock
25 mg	$273	In Stock	In Stock
50 mg	$375	In Stock	In Stock
100 mg	$512	In Stock	In Stock
200 mg	$690	-	In Stock
1 mL x 10 mM (in DMSO)	$103	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.73%

Appearance:Solid

Color:White

Resource Download

COA LCMS FNMR HNMR

Product Introduction

Bioactivity

Description	ATX inhibitor 5 is a potent and orally active autotaxin (ATX) inhibitor (IC50: 15.3 nM) that reduces CCl4-induced hepatic fibrosis and exhibits anti-hepatic fibrosis effects.
Targets&IC50	Stellate cells:0.78 μM, ATX:15.3 nM, Fibroblasts (cardiac):1.21 μM
In vitro	ATX inhibitor 5 (10 μM) successfully suppresses collagen content induced by TGF-β.[1]
In vivo	ATX inhibitor 5 (20-40 mg/kg/d, p.o., two weeks) significantly reduces CCl4-induced hepatic fibrosis levels.[1]

Chemical Properties

Molecular Weight	474.87
Formula	C₂₂H₁₈ClF₃N₆O
Cas No.	2402772-45-4
Smiles	FC(F)(F)c1cccc(Nc2ncnc3CCN(Cc23)C(=O)N\N=C\c2ccc(Cl)cc2)c1
Relative Density.	1.45 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 225 mg/mL (473.81 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (6.95 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1058 mL	10.5292 mL	21.0584 mL	105.2920 mL
5 mM	0.4212 mL	2.1058 mL	4.2117 mL	21.0584 mL
10 mM	0.2106 mL	1.0529 mL	2.1058 mL	10.5292 mL
20 mM	0.1053 mL	0.5265 mL	1.0529 mL	5.2646 mL
50 mM	0.0421 mL	0.2106 mL	0.4212 mL	2.1058 mL
100 mM	0.0211 mL	0.1053 mL	0.2106 mL	1.0529 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc