Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ATX inhibitor 5 is a potent and orally active autotaxin (ATX) inhibitor (IC50 : 15.3 nM) that reduces the level of CCl4-induced hepatic fibrosis and has anti-hepatic fibrosis effects,.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 116.00 | |
5 mg | In stock | $ 289.00 | |
10 mg | In stock | $ 478.00 | |
25 mg | In stock | $ 789.00 | |
50 mg | In stock | $ 1,080.00 | |
100 mg | In stock | $ 1,480.00 | |
500 mg | In stock | $ 2,970.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 295.00 |
Description | ATX inhibitor 5 is a potent and orally active autotaxin (ATX) inhibitor (IC50 : 15.3 nM) that reduces the level of CCl4-induced hepatic fibrosis and has anti-hepatic fibrosis effects,. |
Targets&IC50 | ATX:15.3 nM, Stellate cells:0.78 μM, Fibroblasts (cardiac):1.21 μM |
In vitro | ATX inhibitor 5 (10 μM) successfully suppresses collagen content induced by TGF-β.[1] |
In vivo | ATX inhibitor 5 (20-40 mg/kg/d; p.o.; two weeks) prominently decreases CCl4-induced hepatic fibrosis levels.[1] |
Molecular Weight | 474.87 |
Formula | C22H18ClF3N6O |
CAS No. | 2402772-45-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 225.0 mg/mL (473.8 mM), Sonification is recommended.
You can also refer to dose conversion for different animals. More
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ATX inhibitor 5 2402772-45-4 Metabolism PDE inhibitor inhibit