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Proteases/Proteasome Cysteine Protease Esomeprazole

Esomeprazole

Catalog No. T20626   CAS 119141-88-7

Esomeprazole is the S-isomer of omeprazole, inhibits the lysosomal cysteine protease legumain to prevent cancer metastasis. Esomeprazole is a proton pump inhibitors (PPI).

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Esomeprazole, CAS 119141-88-7
Pack Size Availability Price/USD Quantity
2 mg In stock 52.00
5 mg In stock 75.00
10 mg In stock 99.00
25 mg In stock 194.00
50 mg In stock 311.00
100 mg In stock 581.00
1 mL * 10 mM (in DMSO) In stock 85.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Esomeprazole is the S-isomer of omeprazole, inhibits the lysosomal cysteine protease legumain to prevent cancer metastasis. Esomeprazole is a proton pump inhibitors (PPI).
In vivo In an orthotopic transplantation nude mouse model, Esomeprazole reduced lung metastasis of MDA-MB-231 breast cancer cells[1].
Molecular Weight 345.42
Formula C17H19N3O3S
CAS No. 119141-88-7

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 6 months

Solubility Information

DMSO: Soluble

DMSO: 15 mg/mL (43.43 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Zhao T, et al. Esomeprazole inhibits the lysosomal cysteine protease legumain to prevent cancer metastasis. Invest New Drugs. 2021 Apr;39(2):337-347. 2. Vachhani R, et al. Esomeprazole: a proton pump inhibitor. Expert Rev Gastroenterol Hepatol. 2009 Feb;3(1):15-27. 3. Qi Q,et al. Comparative effectiveness and tolerability of esomeprazole and omeprazole in gastro-esophageal reflux disease: A systematic review and meta-analysis. Int J Clin Pharmacol Ther. 2015 Oct;53(10):803-10. 4. Jankowski JAZ, et al. Esomeprazole and aspirin in Barrett's oesophagus (AspECT): a randomised factorial trial. Lancet. 2018 Aug 4;392(10145):400-408.

Related Products

Related compounds with same targets
LY 3000328 Aurantiamide acetate Vonoprazan Esomeprazole Magnesium trihydrate 2-cyano-Pyrimidine Pantoprazole Z-FA-FMK Tenatoprazole

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