ubiquitination — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T13244	Ubiquitination-IN-1		Others
	Ubiquitination-IN-1 is an inhibitor of ubiquitination and Cksl-Skp2 protein-protein interaction (IC50: 0.17 μM).		Others
T75030	Ubiquitination-IN-2
	Ubiquitination-IN-2 is a potent inhibitor of E1-E2 protein−protein interactions (PPI), displaying inhibitory activity with a dissociation constant (Kd) of 0.72 μM for the ubiquitin E1 (Uba1) enzyme. By blocking the trans...
T21773	SP-141	SP 141	Mdm2
	SP 141 is a MDM2 inhibitor.SP-141 promotes MDM2 auto-ubiquitination and degradation, with anticancer activity.		Mdm2
T8773	MID-1		Others , IGF-1R
	MID-1 is an inhibitor of MG53-IRS-1 (Mitsugumin 53-Insulin Receptor Substrate-1) interaction. It disrupts molecular association of MG53 with IRS-1 and abolishes MG53-induced IRS-1 ubiquitination and degradation in skelet...		Others , IGF-1R
T2026	CYM5442		S1P Receptor , LPL Receptor
	CYM5442 is an S1P agonist, targeting to Sphingosine.		S1P Receptor , LPL Receptor
T6697	TCID	UCH-L3 Inhibitor	DUB
	TCID (UCH-L3 Inhibitor)(IC50=0.6 μM) is a DUB inhibitor of ubiquitin C-terminal hydrolase L3. It has the 125-fold selectivity to L1.		DUB
T1862	PR-619	PR 619,2,6-Diamino-3,5-dithiocyanopyridine	Apoptosis , DUB , Autophagy
	PR-619 (2,6-Diamino-3,5-dithiocyanopyridine) is a non-selective, reversible inhibitor of the deubiquitinylating enzymes (DUBs).		Apoptosis , DUB , Autophagy
T9758	DCeMM3	2-(1H-benzimidazol-2-ylsulfanyl)-N-(5-chloropyridin-2-yl)acetamide	Others
	dCeMM3 (2-(1H-benzimidazol-2-ylsulfanyl)-N-(5-chloropyridin-2-yl)acetamide) is a glue degrader. dCeMM3 prompts an interaction of CDK12-cyclin K with a CRL4B ligase complex, result in inducing ubiquitination and degradati...		Others
T4970	LANOSTEROL	3β-Hydroxy-8,24-lanostadiene,8,24-Lanostadien-3β-ol	Endogenous Metabolite
	Lanosterol (3β-Hydroxy-8,24-lanostadiene) is a tetracyclic triterpenoid which is the compound from which all steroids are derived.		Endogenous Metabolite
T8931L	ICCB-19 hydrochloride	ICCB-19 HCl（750621-52-4 free base）	Apoptosis , Others , Autophagy , RIP kinase
	ICCB-19 hydrochloride (ICCB-19 HCl) is an inhibitor of TRADD (TNFRSF1A Associated Via Death Domain). It binds to a pocket on the N-terminal TRAF2-binding domain of TRADD (TRADD-N), which interacts with the C-terminal dom...		Apoptosis , Others , Autophagy , RIP kinase
T25465	GS143	GS-143,GS 143	IκB/IKK , E1/E2/E3 Enzyme , NF-κB
	GS143 is a selective IκBα ubiquitination inhibitor with an IC50 of 5.2 μM for SCFβTrCP1-mediated IκBα ubiquitylation. GS143 suppresses NF-κB activation and transcription of target genes and does not inhibit protea...		IκB/IKK , E1/E2/E3 Enzyme , NF-κB
T17187	TZ9		Apoptosis , E1/E2/E3 Enzyme
	TZ9 is a selective and potent Rad6 inhibitor with anticancer and anti-tumor activity.TZ9 inhibits Rad6B-induced ubiquitination of histone H2A.TZ9 induces cell cycle arrest and apoptosis.		Apoptosis , E1/E2/E3 Enzyme
T1919	Tenovin-1	Tenovin 1	Mdm2 , Dehydrogenase , Sirtuin , p53 , Autophagy
	Tenovin-1 inhibits protein-deacetylating activities of SirT1 and SirT2 and protects against MDM2-mediated p53 degradation, which involves ubiquitination.		Mdm2 , Dehydrogenase , Sirtuin , p53 , Autophagy
T37042	SCH529074	SCH 529074	p53
	SCH529074 is a selective activator of p53 (Ki = 1 μM) and can be used in studies about non-small-cell lung carcinoma. SCH529074 restores mutant p53 function and interrupts HDM2-mediated ubiquitination of wild Type p53.		p53
T2140	Parthenolide	(-)-Parthenolide	Apoptosis , Mitophagy , NF-κB , HDAC , Autophagy
	(-)-Parthenolide ((-)-Parthenolide), an inhibitor of the Nuclear Factor-κB Pathway, also promotes the ubiquitination of MDM2 and activates p53 cellular functions.		Apoptosis , Mitophagy , NF-κB , HDAC , Autophagy
T64339	Apcin A HCL		APC
	Apcin A HCL is an Apcin derivative. Apcin A HCL is an anaphase-promoting complex (APC) inhibitor. Apcin-A HCL interacts strongly with Cdc20, and inhibits the ubiquitination of Cdc20 substrates. Apcin-A HCL can be used to...		APC
T36682	USP30 inhibitor 18		DUB
	USP30 inhibitor 18 is a selective USP30 inhibitor with an IC50 of 0.02 μM. USP30 inhibitor 18 increases protein ubiquitination and accelerates mitophagy[1]. [1]. Arthur F Kluge, et al. Novel highly selective inhibitors o...		DUB
T61477	DCeMM2		Molecular Glues
	dCeMM2 is a glue degrader. dCeMM2 prompts an interaction of CDK12-cyclin K with a CRL4B ligase complex, leading to the ubiquitination and degradation of cyclin K.		Molecular Glues
T16904	Smurf1-IN-A01	A01	Others
	Smurf1-IN-A01 (A01) is a ubiquitin ligase Smad ubiquitination regulatory factor-1 inhibitor (kd: 3.664 nM). It increases BMP-2 responsiveness by inhibiting Smurf1-mediated Smad1/5 degradation.		Others
T73560	I-138		DUB
	I-138 is an orally active and potent reversible inhibitor of USP1-UAF1.I-138 induces mono-ubiquitination of FANCD2 and PCNA and inhibits USP1 auto-cleavage in cells.		DUB