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TCID

Catalog No. T6697 CAS 30675-13-9

Synonyms: UCH-L3 Inhibitor

TCID (UCH-L3 Inhibitor)(IC50=0.6 μM) is a DUB inhibitor of ubiquitin C-terminal hydrolase L3. It has the 125-fold selectivity to L1.

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TCID, CAS 30675-13-9

Pack Size	Availability	Price/USD
2 mg	In stock	$ 33.00
5 mg	In stock	$ 52.00
10 mg	In stock	$ 80.00
25 mg	In stock	$ 178.00
50 mg	In stock	$ 231.00
100 mg	In stock	$ 300.00
1 mL * 10 mM (in DMSO)	In stock	$ 56.00

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Purity: 99.47%

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Description	TCID (UCH-L3 Inhibitor)(IC50=0.6 μM) is a DUB inhibitor of ubiquitin C-terminal hydrolase L3. It has the 125-fold selectivity to L1.
Targets&IC50	UCHL3:0.6 μM
In vitro	TCID is selective for UCH-L3 over UCH-L1 by over 100-fold. [1] NU6027 (10 μM) does not promote YFP-GLT-1 accumulation in intracellular vesicles in transfected MDCK cells, while LDN-57444 (10 μM) promotes YFP-GLT-1 accumulation. NU6027 (10 μM) does not produce long-term lysosomal degradation of GLT-1, while LDN-57444 (10 μM) has such effect. [2] TCID (10 μM) diminishes GlyT2 ubiquitination in brainstem and spinal cord primary neurons, which is more pronounced when UCHL1 is inhibited and when cells are exposed to these inhibitors for longer periods. [3]

Synonyms	UCH-L3 Inhibitor
Molecular Weight	283.92
Formula	C9H2Cl4O2
CAS No.	30675-13-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 14.2 mg/mL (50 mM)

References and Literature

1. Liu Y, et al. Chem Biol, 2003, 10(9), 837-846. 2. Martínez-Villarreal J, et al. Glia, 2012, 60(9), 1356-1365 3. de Juan-Sanz J, et al. PLoS One, 2013, 8(3), e58863.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Highly Selective Inhibitor Library Bioactive Compounds Library Max Autophagy Compound Library DNA Damage & Repair Compound Library Anti-Aging Compound Library Ubiquitination Compound Library Bioactive Compound Library Anti-Cancer Compound Library Cell Cycle Compound Library

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Keywords

TCID 30675-13-9 Cell Cycle/Checkpoint DNA Damage/DNA Repair Ubiquitination DUB hydrolase C-terminal Neuronal Deubiquitinase transporter UCH-L3 Inhibitor ubiquitination DUBs inhibit glycine ubiquitin UCH-L3 UCH-L1 GlyT2 Inhibitor inhibitor

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