Powder: -20°C for 3 years | In solvent: -80°C for 1 year
TZ9 is a selective and potent Rad6 inhibitor with anticancer and anti-tumor activity.TZ9 inhibits Rad6B-induced ubiquitination of histone H2A.TZ9 induces cell cycle arrest and apoptosis.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | In stock | $ 46.00 | |
5 mg | In stock | $ 72.00 | |
10 mg | In stock | $ 129.00 | |
25 mg | In stock | $ 267.00 | |
50 mg | In stock | Inquiry |
Description | TZ9 is a selective and potent Rad6 inhibitor with anticancer and anti-tumor activity.TZ9 inhibits Rad6B-induced ubiquitination of histone H2A.TZ9 induces cell cycle arrest and apoptosis. |
In vitro |
In MDA-MB-231 cells, TZ9 (Rad6B SMI #9) inhibits proliferation and migration when administered at concentrations ranging from 0.5 to 100 µM for 72 hours[1]. Cell-cycle progression delay is observed in MDA-MB-231 cells treated with TZ9 at concentrations ranging from 0.1 to 5 µM over a period of 24 to 72 hours[1]. Apoptosis induction is noted in MDA-MB-231 cells exposed to TZ9 at a concentration of 5 µM for 8 to 48 hours[1]. In MDA-MB-231 cells, TZ9 exhibits inhibitory effects on H2A ubiquitination and downregulates levels of PCNA and β-catenin protein when applied at concentrations of 0.5, 1, 2.5, and 5 µM for 24 hours[1]. |
Molecular Weight | 366.33 |
Formula | C17H14N6O4 |
CAS No. | 1002789-86-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 40 mg/mL (109.19 mM)
You can also refer to dose conversion for different animals. More
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TZ9 1002789-86-7 Apoptosis Ubiquitination E1/E2/E3 Enzyme TZ-9 TZ 9 inhibitor inhibit