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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T76787 | Conatumumab | TRAIL-R2 mAb,AMG 655 | TNF |
Conatumumab (AMG 655) is a monoclonal agonist antibody targeting human death receptor 5 (DR5, TRAILR2) at Kd 1 nM for long DR5 and Kd 0.8 nM for short DR5. Conatumumab induces apoptosis in a variety of tumor types throug... | |||
T3862 | Irigenin | NF-κB , Integrin | |
Irigenin mediates its antimetastatic effect by specifically and selectively blocking the α9β1 and α4β1 integrin binding sites on the C-C loop of the Extra Domain A domain. It can sensitize TRAIL-induced apoptosis by enha... | |||
T8969 | API-1 | NSC177223 | Akt |
API-1 (NSC-177223) is a potent inhibitor of Akt. It induces GSK3-dependent, β-TrCP- and FBXW7-mediated Mcl-1 degradation, resulting in induction of apoptosis . | |||
T7001 | TIC10 | ONC-201 | Apoptosis , TNF |
TIC10 (ONC-201) inactivates Akt and ERK to induce TRAIL through Foxo3a, possesses superior drug properties: delivery across the blood-brain barrier, superior stability and improved pharmacokinetics. Phase 1/2. | |||
T2065 | Bioymifi | DR5 Activator | Apoptosis , TNF |
Bioymifi (DR5 Activator) is a novel and potent small-molecule activator of the TRAIL receptor DR5 in human cancer cells. | |||
T76815 | Lexatumumab | ETR2-ST01,DR5 mAB,HGS-ETR 2 | Apoptosis |
Lexatumumab (GHS-ETR 2) is a human excitatory monoclonal antibody targeting TRAIL receptor 2 that has anticancer activity and induces apoptosis in malignant mesothelioma. Lexatumumab can be used to study malignant pleura... | |||
T30969 | Clitocine | Apoptosis , BCL | |
Clitocine, an adenosine analogue derived from mushrooms, is a potent transcriptional readout agent, an inhibitor of nonsense mutations, and has anticancer activity, inducing the production of p53 protein in cells carryin... | |||
T6705 | TIC10 Isomer | ONC201 isomer,TIC10 Analogue | Others |
TIC10 Isomer (ONC201 isomer) is an isomer of TIC10, which inactivates Akt and ERK to induce TRAIL through Foxo3a, possesses superior drug properties: delivery across the blood-brain barrier, superior stability and improv... | |||
T16392 | ONC206 | Dopamine Receptor | |
ONC206, an analogue of the TRAIL inducer ONC201, acts as a selective antagonist of the D2-like dopamine receptors (DRD2/3/4) at nanomolar concentrations and possesses broad-spectrum anti-tumor activity. | |||
T4423 | LY 303511 hydrochloride | LY303511 hydrochloride | Potassium Channel , TNF , mTOR |
LY 303511 hydrochloride is a potent mTOR inhibitor | |||
T6776 | BAY 61-3606 dihydrochloride | BAY 61-3606,BAY-61-3606 dihydrochloride | Apoptosis , Syk |
BAY 61-3606 dihydrochloride (BAY 61-3606) is a potent and selective inhibitor of Syk kinase (Ki = 7.5 nM). | |||
T4263 | BAY 61-3606 | Syk inhibitor IV | Apoptosis , Syk |
BAY 61-3606 (Syk inhibitor IV) is a potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase activity (Ki= 7.5 nM), exhibiting no inhibitory effect against Btk, Fyn, Itk, Lyn, and Src. | |||
T32072 | Hexyl decanoate | Decanoic acid hexyl ester | |
Hexyl decanoate, the first trail pheromone compound identified in a stingless bee, Trigona recursa. Hexyl decanoate is dominant component of gland secretions. | |||
T23859 | CaspPro | C-2,C 2,Casp-Pro,Casp Pro,C2 | |
CaspPro is a selective activator of caspase 8 that acts by potentiating TRAIL-induced cell death. | |||
T70352 | PH11 | ||
PH11 is a novel Focal Adhesion Kinase (FAK) inhibitor. PH11 restores TRAIL apoptotic pathway in PANC-1 cells through down-regulation of c-FLIP via inhibition of FAK and the phosphatidylinositol-3 kinase (PI3K)/AKT path... | |||
T33892 | PBOX-15 | ||
PBOX-15 is a novel microtubule-targeting agent that induces apoptosis, upregulates death receptors, and enhances TRAIL-mediated apoptosis in multiple myeloma cells. It also inhibits T cell migration through post-translat... | |||
T82578 | Desacetylxanthanol | ||
Desacetylxanthanol (Compound 4), a sesquiterpenoid originating from Xanthium strumarium, exhibits anti-tumor necrosis factor-associated apoptosis-inducing ligand (TRAIL) activity [1]. | |||
TN4038 | Eupatolide | TNF , NOS , NF-κB , ROS , MAPK , Akt , COX , DNA/RNA Synthesis , Nrf2 , PDGFR , NO Synthase , Prostaglandin Receptor , Autophagy | |
Eupatolide is isolated from the flowers of Inula japonica with anti-inflammatory activity. Eupatolide can be used in studies about TRAIL resistance in breast cancer cells. | |||
T26709 | Azadirone | ||
Azadirone is a limonoid tetranortriterpene. Azadirone can sensitize cancer cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) through ROS-ERK-CHOP-mediated up-regulation of DR4 and DR5 signaling, do... | |||
T35729 | Nemadipine-A | ||
Nemadipine A is an L-type calcium channel blocker that induces morphological and growth defects in wild-type C. elegans and those with hypoexpression of egl-19, which encodes the only L-type calcium channel α1-subunit in... |