Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ONC206, an analogue of the TRAIL inducer ONC201, acts as a selective antagonist of the D2-like dopamine receptors (DRD2/3/4) at nanomolar concentrations and possesses broad-spectrum anti-tumor activity.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 34.00 | |
2 mg | In stock | $ 48.00 | |
5 mg | In stock | $ 77.00 | |
10 mg | In stock | $ 126.00 | |
25 mg | In stock | $ 207.00 | |
50 mg | In stock | $ 369.00 | |
100 mg | In stock | $ 549.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 71.00 |
Description | ONC206, an analogue of the TRAIL inducer ONC201, acts as a selective antagonist of the D2-like dopamine receptors (DRD2/3/4) at nanomolar concentrations and possesses broad-spectrum anti-tumor activity. |
In vitro | ONC206 (Oncoceutics) is an imipiridone with nanomolar potency and analogue of ONC201, a selective dopamine receptor D2 (DRD2) antagonist currently being investigated in phase II clinical trials for serous endometrial cancer (SEC).??ONC206 inhibited cellular proliferation in a dose-dependent manner and was more potent than ONC201 in the ARK1 (IC50 = 0.33 M vs. IC50 = 1.59uM) and SPEC-2 (IC50 = 0.24uM vs. IC50 = 0.81uM) cell lines.?Treatment with ONC206 resulted in induction of ROS production and reduction of mitochondrial membrane potential, accompanied by an increase in cleaved caspase-3 and caspase-9 activity (p 0.01).?ONC206 also significantly inhibited cellular adhesion and migration in both cell lines (p 0.01).?Pretreatment with the stress inhibitor N-acetylcysteine (NAC) significantly attenuated the efficacy of ONC206 on cell proliferation, ROS production and cellular invasion.?ONC206 demonstrates nanomolar potency for the inhibition of proliferation in SEC cells[3]. |
In vivo | ONC206 (100 mg/kg; p.o.; every 10 days) reduces obviously tumor growth inhibition[2]. |
Molecular Weight | 408.44 |
Formula | C23H22F2N4O |
CAS No. | 1638178-87-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (244.83 mM), Sonification is recommended.
You can also refer to dose conversion for different animals. More
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ONC206 1638178-87-6 GPCR/G Protein Neuroscience Dopamine Receptor antagonist Inhibitor ONC201 DRD2/3/4 inhibit receptors D2-like ONC 206 dopamine ONC-206 inhibitor