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Eupatolide

Catalog No. TN4038   CAS 6750-25-0

Eupatolide is isolated from the flowers of Inula japonica with anti-inflammatory activity. Eupatolide can be used in studies about TRAIL resistance in breast cancer cells.

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Eupatolide Chemical Structure
Eupatolide, CAS 6750-25-0
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Eupatolide is isolated from the flowers of Inula japonica with anti-inflammatory activity. Eupatolide can be used in studies about TRAIL resistance in breast cancer cells.
In vitro Eupatolide exhibits potent cytotoxicity against HL-60, SMMC-7721, A-549, MCF-7, and SW-480 cancer cell lines (IC50: 1.57 to 22.58 uM). Eupatolide sensitizes breast cancer cells to TRAIL through the down-regulation of c-FLIP expression. In RAW264.7 cells, Eupatolide inhibits lipopolysaccharide-induced COX-2 and iNOS expression by inducing proteasomal degradation of TRAF6. Eupatolide suppresses PDGF-induced proliferation and migration of VSMC through HO-1 induction via ROS-Nrf2 pathway and may be a potential HO-1 inducer for preventing or treating vascular diseases[1].
Molecular Weight 248.32
Formula C15H20O3
CAS No. 6750-25-0

Storage

store at low temperture,keep away from direct sunlight

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

TargetMolReferences and Literature

1. Wu XD, et al. Bioactive sesquiterpenoids from the flowers of Inula japonica. Phytochemistry. 2016 Sep;129:68-76. 2. Lee J, et al. Eupatolide inhibits lipopolysaccharide-induced COX-2 and iNOS expression in RAW264.7 cells by inducing proteasomal degradation of TRAF6. Eur J Pharmacol. 2010 Jun 25;636(1-3):173-80.

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Keywords

Eupatolide 6750-25-0 Angiogenesis Apoptosis Autophagy Cell Cycle/Checkpoint Cytoskeletal Signaling DNA Damage/DNA Repair GPCR/G Protein Immunology/Inflammation MAPK Neuroscience NF-Κb PI3K/Akt/mTOR signaling Tyrosine Kinase/Adaptors TNF NOS NF-κB COX Akt DNA/RNA Synthesis ROS Nrf2 Prostaglandin Receptor PDGFR NO Synthase inhibitor inhibit

 

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