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LY 303511 hydrochloride
🥰Excellent
Catalog No. T4423Cas No. 2070014-90-1
Alias LY303511 hydrochloride
LY 303511 hydrochloride is a potent mTOR inhibitor
LY 303511 hydrochloride
🥰Excellent
Purity: 98.47%
Catalog No. T4423Alias LY303511 hydrochlorideCas No. 2070014-90-1
LY 303511 hydrochloride is a potent mTOR inhibitor
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $33 | In Stock | |
| 5 mg | $76 | In Stock | |
| 10 mg | $128 | In Stock | |
| 25 mg | $263 | In Stock | |
| 50 mg | $493 | In Stock | |
| 100 mg | $718 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $84 | In Stock |
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Purity:98.47%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | LY 303511 hydrochloride is a potent mTOR inhibitor |
| Targets&IC50 | mTOR: |
| In vitro | LY303511 enhances TRAIL sensitivity of SHEP-1 neuroblastoma cells via hydrogen peroxide-mediated mitogen-activated protein kinase activation and up-regulation of death receptors. LY303511 amplifies TRAIL-induced apoptosis in tumor cells by enhancing DR5 oligomerization, DISC assembly, and mitochondrial permeabilization. LY303511 acts via phosphatidylinositol 3-kinase-independent pathways to inhibit cell proliferation via mammalian target of rapamycin (mTOR)- and non-mTOR-dependent mechanisms. |
| Alias | LY303511 hydrochloride |
| Molecular Weight | 342.82 |
| Formula | C19H19ClN2O2 |
| Cas No. | 2070014-90-1 |
| Smiles | Cl.O=c1cc(oc2c(cccc12)-c1ccccc1)N1CCNCC1 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 50 mg/mL (145.85 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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