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LY 303511 hydrochloride

Catalog No. T4423 CAS 2070014-90-1

Synonyms: LY303511 hydrochloride

LY303511 (NV-128)is a potent mTOR inhibitor

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

LY 303511 hydrochloride Chemical Structure

LY 303511 hydrochloride, CAS 2070014-90-1

Pack Size	Availability	Price/USD
1 mg	In stock	$ 33.00
5 mg	In stock	$ 76.00
10 mg	In stock	$ 128.00
25 mg	In stock	$ 263.00
50 mg	In stock	$ 493.00
100 mg	In stock	$ 718.00
1 mL * 10 mM (in DMSO)	In stock	$ 84.00

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Purity: 97.44%

Biological Description

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Description	LY303511 (NV-128)is a potent mTOR inhibitor
Targets&IC50	mTOR:
In vitro	LY303511 enhances TRAIL sensitivity of SHEP-1 neuroblastoma cells via hydrogen peroxide-mediated mitogen-activated protein kinase activation and up-regulation of death receptors. LY303511 amplifies TRAIL-induced apoptosis in tumor cells by enhancing DR5 oligomerization, DISC assembly, and mitochondrial permeabilization. LY303511 acts via phosphatidylinositol 3-kinase-independent pathways to inhibit cell proliferation via mammalian target of rapamycin (mTOR)- and non-mTOR-dependent mechanisms.

Synonyms	LY303511 hydrochloride
Molecular Weight	342.82
Formula	C19H19ClN2O2
CAS No.	2070014-90-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

DMSO: 50 mg/mL (145.85 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Shi Y,etal.Computational modelling of LY303511 and TRAIL-induced apoptosis suggests dynamic regulation of cFLIP.Bioinformatics. 2013 Feb 1;29(3):347-54. 2. Tucker-Kellogg L,etal.Reactive oxygen species (ROS) and sensitization to TRAIL-induced apoptosis, in Bayesian network modelling of HeLa cell response to LY303511.Biochem Pharmacol. 2012 Nov 15;84(10):1307-17. 3. Shenoy K,etal.LY303511 enhances TRAIL sensitivity of SHEP-1 neuroblastoma cells via hydrogen peroxide-mediated mitogen-activated protein kinase activation and up-regulation of death receptors.Cancer Res. 2009 Mar 1;69(5):1941-50.

Related compound libraries

This product is contained In the following compound libraries：

Oxidation-Reduction Compound Library Anti-Aging Compound Library Neuronal Differentiation Compound Library Bioactive Compound Library Kinase Inhibitor Library Metabolism Compound Library Anti-Breast Cancer Compound Library Anti-Ovarian Cancer Compound Library Autophagy Compound Library Anti-Cancer Metabolism Compound Library

Related Products

Related compounds with same targets

KT-362 fumarate CHET3 Vesnarinone HCl PD-118057 Celivarone BMS-394136 Maralixibat Chloride LY 303511

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

LY 303511 hydrochloride 2070014-90-1 Apoptosis Membrane transporter/Ion channel PI3K/Akt/mTOR signaling Potassium Channel TNF mTOR TNFR LY-303511 TNF Receptor inhibit LY 303511 Tumor Necrosis Factor Receptor Inhibitor LY303511 hydrochloride LY303511 KcsA inhibitor

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