Powder: -20°C for 3 years | In solvent: -80°C for 2 years
LY303511 (NV-128)is a potent mTOR inhibitor
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 33.00 | |
5 mg | In stock | $ 76.00 | |
10 mg | In stock | $ 128.00 | |
25 mg | In stock | $ 263.00 | |
50 mg | In stock | $ 493.00 | |
100 mg | In stock | $ 718.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 84.00 |
Description | LY303511 (NV-128)is a potent mTOR inhibitor |
Targets&IC50 | mTOR: |
In vitro | LY303511 enhances TRAIL sensitivity of SHEP-1 neuroblastoma cells via hydrogen peroxide-mediated mitogen-activated protein kinase activation and up-regulation of death receptors. LY303511 amplifies TRAIL-induced apoptosis in tumor cells by enhancing DR5 oligomerization, DISC assembly, and mitochondrial permeabilization. LY303511 acts via phosphatidylinositol 3-kinase-independent pathways to inhibit cell proliferation via mammalian target of rapamycin (mTOR)- and non-mTOR-dependent mechanisms. |
Synonyms | LY303511 hydrochloride |
Molecular Weight | 342.82 |
Formula | C19H19ClN2O2 |
CAS No. | 2070014-90-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
DMSO: 50 mg/mL (145.85 mM)
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
LY 303511 hydrochloride 2070014-90-1 Apoptosis Membrane transporter/Ion channel PI3K/Akt/mTOR signaling Potassium Channel TNF mTOR TNFR LY-303511 TNF Receptor inhibit LY 303511 Tumor Necrosis Factor Receptor Inhibitor LY303511 hydrochloride LY303511 KcsA inhibitor