tgf-β1 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
TN1644	Flavanomarein		Others
	Flavanomarein demonstrates potent antioxidative property, including free radical scavenging activity, inhibition of lipid peroxidation, as well as lipid-lowering effects in human HepG2 hepatocellular carcinoma cells trea...		Others
T13741	Isoviolanthin		Others
	Isoviolanthin reduces the migratory and invasive capacities of TGF-β1-treated HCC cells without cytotoxic effects on normal live cells and has potential as a therapeutic agent for the treatment of advanced-stage metastat...		Others
T3636	(E)-SIS3	SIS3,SIS3 HCl	TGF-beta/Smad
	(E)-SIS3 (SIS3), a selective Smad3 inhibitor, can attenuate TGF-β1-dependent Smad3 phosphorylation and DNA binding. It has no effect on p38 MAPK, Smad2, ERK or PI3K signaling. It also inhibits TGF-β1-induced myofibroblas...		TGF-beta/Smad
T0518	Methacycline hydrochloride	Rondomycin,Methacycline HCl	ribosome , Antibacterial , Antibiotic
	Methacycline hydrochloride (Rondomycin) is a broad-spectrum semisynthetic antibiotic related to TETRACYCLINE but excreted more slowly and maintaining effective blood levels for a more extended period.		ribosome , Antibacterial , Antibiotic
TN1471	Cassiaside C	Toralactone 9-O-β-D-gentiobioside	Others , Endogenous Metabolite
	Cassiaside C (Toralactone 9-O-β-D-gentiobioside), a naphthopyrone extracted from Cassia tora seeds, exhibits in vitro inhibitory activity against the formation of advanced glycation end products (AGE).		Others , Endogenous Metabolite
T0459	Sulindac	Arthrocine,MK-231,Clinoril,Sulindac sulfoxide	COX , Autophagy
	Sulindac (Sulindac sulfoxide) is a sulfinylindene derivative prodrug with potential antineoplastic activity. Converted in vivo to an active metabolite, sulindac, a nonsteroidal anti-inflammatory drug (NSAID), blocks cycl...		COX , Autophagy
T3876	Loureirin B		PAI-1 , ERK , Potassium Channel , JNK
	Loureirin B can downregulate the expression of fibrosis-related molecules by regulating MMPs and TIMPs levels, inhibit scar fibroblast proliferation and suppress TGF-β1-induced fibrosis, during which TGF-β1/Smad2/3 pathw...		PAI-1 , ERK , Potassium Channel , JNK
T61389	TGFβ1-IN-1
	TGFβ1-IN-1 (compound 42), an orally active, potent inhibitor of TGF-β1, suppresses the upregulation of fibrosis markers α-SMA and fibronectin, showcasing its utility in the study of liver fibrosis disease [1].
T73300	AXL-IN-13		FLT , TAM Receptor , PDGFR , TGF-beta/Smad
	AXL-IN-13 is a potent and orally active AXL inhibitor with an IC50 value of 1.6 nM and a Kd value of 0.26 nM.AXL-IN-13 exhibits anticancer activity, reverses TGF-β1-induced epithelial-mesenchymal transition (EMT) and inh...		FLT , TAM Receptor , PDGFR , TGF-beta/Smad
T1763	SB 525334	SB525334	ALK , TGF-beta/Smad
	SB-525334 is a potent and selective inhibitor of the TGF-β1R and ALK5 (IC50: 14.3 nM).		ALK , TGF-beta/Smad
T38752	EW-7195		ALK , TGF-beta/Smad
	EW-7195 is a selective and potent inhibitor of ALK5 (TGFβR1) with an IC50 value of 4.83 nM.EW-7195 has an affinity for ALK5 that is more than 300-fold higher than that of p38α.EW-7195 has an inhibitory effect on TGF-β1-i...		ALK , TGF-beta/Smad
T32613	LCB 03-0110 dihydrochloride		Src
	LCB 03-0110 Dihydrochloride is a potent inhibitor of the c-Src kinase (IC50 = 1.3 nM) and tyrosine kinases in the BTK and SYK family, as well as in the DDR2 family. It inhibits LPS-induced activation of macrophages and T...		Src
T11052L	Disitertide acetate	P144 acetate,Disitertide acetate(272105-42-7 Free base)	TGF-beta/Smad
	Disitertide acetate (P144 acetate) is a peptidic transforming growth factor-beta 1 (TGF-β1) inhibitor specifically designed to block the interaction with its receptor. Disitertide acetate is also a PI3K inhibitor and an ...		TGF-beta/Smad
T9953	BT173		Others
	BT173 is a novel inhibitor of homeodomain interacting protein kinase 2 (HIPK2 ), attenuating renal fibrosis through suppression of the TGF-ß1/Smad3 pathway.		Others
T11793	KY-05009		Wnt/beta-catenin
	KY-05009 is a chemical compound that effectively suppresses TGF-β1-induced epithelial-to-mesenchymal transition (EMT) in human lung adenocarcinoma cells, reduces TNIK protein expression and the transcriptional activity o...		Wnt/beta-catenin
T5688	Micheliolide		NOS , NF-κB , COX
	Micheliolide(MCL) is a sesquiterpene lactone which inhibits various inflammatory response.		NOS , NF-κB , COX
T62483	CJJ300		TGF-beta/Smad
	CJJ300 is a transforming growth factor-β (TGF-β) inhibitor (IC50 : 5.3 μM).CJJ300 inhibits TGF-β signaling by disrupting the formation of the TGF-β-TβR-I-TβR-II signaling complex.CJJ300 inhibits cell migration.		TGF-beta/Smad
T3S1416	Decursin	Decursinol angelate,(+)-Decursin	Apoptosis , PKC
	1. Decursin (Decursinol angelate) is able to attenuate kainic acid-induced seizures and could have potential as an antiepileptic drug. 2. Decursin exhibits hepatoprotective effects , potentially by inhibiting the TGF-β1 ...		Apoptosis , PKC
T3795	Corilagin		Apoptosis , TLR , Reverse Transcriptase , Antibacterial , Autophagy
	Corilagin has anti-inflammatory activity. Corilagin has a significant antitumour potential and lower toxicity in normal cells in vitro.Corilagin can enhance the cytotoxicity of both cisplatin and doxorubicin on the Hep3B...
T4938	Potassium 1H-indol-3-yl sulfate	Indoxyl sulfate potassium salt,Potassium 3-indoxyl sulfate	AhR , Endogenous Metabolite
	Potassium 1H-indol-3-yl sulfate (Potassium 3-indoxyl sulfate) is an agonist for the human Aryl Hydrocarbon Receptor (AhR). The Aryl Hydrocarbon Receptor (AhR) has recently emerged as a pathophysiological regulator of imm...		AhR , Endogenous Metabolite