Powder: -20°C for 3 years | In solvent: -80°C for 1 year
LCB 03-0110 Dihydrochloride is a potent inhibitor of the c-Src kinase (IC50 = 1.3 nM) and tyrosine kinases in the BTK and SYK family, as well as in the DDR2 family. It inhibits LPS-induced activation of macrophages and TGF-β1-induced activation of fibroblasts in vitro, inhibits activation of macrophages and fibroblasts, and inhibits scarring in wound healing models.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 119.00 | |
2 mg | In stock | $ 178.00 | |
5 mg | In stock | $ 273.00 | |
10 mg | In stock | $ 398.00 | |
25 mg | In stock | $ 665.00 | |
50 mg | In stock | $ 947.00 | |
100 mg | In stock | $ 1,280.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 331.00 |
Description | LCB 03-0110 Dihydrochloride is a potent inhibitor of the c-Src kinase (IC50 = 1.3 nM) and tyrosine kinases in the BTK and SYK family, as well as in the DDR2 family. It inhibits LPS-induced activation of macrophages and TGF-β1-induced activation of fibroblasts in vitro, inhibits activation of macrophages and fibroblasts, and inhibits scarring in wound healing models. |
In vitro | LCB 03-0110 treatment of cells exposed to TGF-β1 and type I collagen showed a marked inhibition preferentially in the phosphorylation of tyrosine 861, to give approximately 50% reduction at 1 μM and an almost complete abolishment at 3 μM. |
Molecular Weight | 490.45 |
Formula | C24H25Cl2N3O2S |
CAS No. | 1962928-28-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 30 mg/mL (61.17 mM)
You can also refer to dose conversion for different animals. More
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LCB 03-0110 dihydrochloride 1962928-28-4 Angiogenesis Tyrosine Kinase/Adaptors Src LCB 03-0110 LCB 030110 dihydrochloride LCB 03 0110 dihydrochloride LCB 03-0110 Dihydrochloride inhibitor inhibit