keep away from direct sunlight,store under nitrogen
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Methacycline hydrochloride (Rondomycin) is a broad-spectrum semisynthetic antibiotic related to TETRACYCLINE but excreted more slowly and maintaining effective blood levels for a more extended period.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
100 mg | In stock | $ 52.00 | |
200 mg | In stock | $ 81.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 45.00 |
Description | Methacycline hydrochloride (Rondomycin) is a broad-spectrum semisynthetic antibiotic related to TETRACYCLINE but excreted more slowly and maintaining effective blood levels for a more extended period. |
In vitro | Methacycline, within pulmonary alveolar macrophages, does not alter the response gene of TGF-β1 nor attenuates the aggregation of inflammatory cells. Following tracheal aspiration of bleomycin, intraperitoneal injection of Methacycline at 100 mg/kg, starting on day 10, enhances survival rates by day 17. Methacycline mitigates bleomycin-induced classical EMT (Epithelial-Mesenchymal Transition) markers, including SNAIL1, TWIST1, type I collagen, fibronectin, and their mRNA expressions. |
In vivo | Methacycline inhibits the TGF-β1-induced non-Smad signaling pathways, including the activation of c-Jun N-terminal kinase (JNK), p38, and Akt, without suppressing Smad or β-catenin transcriptional activities. It does not affect the baseline activities of JNK, p38, or Akt, nor the TGF-β1 response of lung fibroblasts. Additionally, methacycline inhibits the TGF-β1-induced expression of α-smooth muscle actin (α-SMA), SNAIL1, and type I collagen in primary alveolar epithelial cells. |
Synonyms | Rondomycin, Methacycline HCl |
Molecular Weight | 478.88 |
Formula | C22H23ClN2O8 |
CAS No. | 3963-95-9 |
keep away from direct sunlight,store under nitrogen
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 27.5 mg/mL (57.43 mM)
You can also refer to dose conversion for different animals. More
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Methacycline hydrochloride 3963-95-9 Microbiology/Virology ribosome Antibacterial Antibiotic fibrosis fibrogenesis c-Jun TGF-β1 Rondomycin Methacycline N-terminal Inhibitor p38 inhibit Bacterial epithelial-mesenchymal kinase Smad transition EMT Methacycline HCl pulmonary Methacycline Hydrochloride Akt inhibitor