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Flavanomarein

Catalog No. TN1644 CAS 577-38-8

Flavanomarein demonstrates potent antioxidative property, including free radical scavenging activity, inhibition of lipid peroxidation, as well as lipid-lowering effects in human HepG2 hepatocellular carcinoma cells treated with free fatty acids (FFAs).

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Flavanomarein, CAS 577-38-8

Pack Size	Availability	Price/USD
1 mg	In stock	$ 64.00
5 mg	In stock	$ 147.00
10 mg	In stock	$ 218.00
25 mg	In stock	$ 366.00
50 mg	In stock	$ 543.00
1 mL * 10 mM (in DMSO)	In stock	$ 169.00

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Purity: 98.63%

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Description	Flavanomarein demonstrates potent antioxidative property, including free radical scavenging activity, inhibition of lipid peroxidation, as well as lipid-lowering effects in human HepG2 hepatocellular carcinoma cells treated with free fatty acids (FFAs).
In vitro	The present study aimed to identify the active compounds of Coreopsis tinctoria and to investigate the molecular mechanisms underlying its effects on lipid dysregulation by measuring lipid levels, reactive oxygen species, lipid peroxidation and fatty acid synthesis. The present results demonstrated that snow chrysanthemum aqueous extracts significantly reduced serum lipid levels and oxidative stress in vivo. The main compounds that were isolated were identified as Flavanomarein (compound 1) and eriodictyol 7-O-β-D glucopyranoside (compound 2). Compounds 1 and 2 demonstrated potent antioxidative properties, including free radical scavenging activity, inhibition of lipid peroxidation, as well as lipid-lowering effects in human HepG2 hepatocellular carcinoma cells treated with free fatty acids (FFAs). Compound 2 was revealed to suppress the elevation of triglyceride levels and inhibit lipid peroxidation following FFA treatment. In addition, it was demonstrated to significantly reduce intracellular levels of reactive oxygen species and improve the mitochondrial membrane potential and adenosine triphosphate levels, thus protecting mitochondrial function in FFA-treated HepG2 cells. Furthermore, compound 2 markedly suppressed the protein expression levels of disulfide-isomerase A3 precursor and fatty acid synthase, thus suppressing FFA-induced lipogenesis in HepG2 cells[1]
Source	Natural Products > Asteraceae > Laurentia

Molecular Weight	450.39
Formula	C21H22O11
CAS No.	577-38-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 60 mg/mL (133.22 mM)

References and Literature

1. Eriodictyol 7-O-β-D glucopyranoside from Coreopsis tinctoria Nutt. ameliorates lipid disorders via protecting mitochondrial function and suppressing lipogenesis.Mol Med Rep. 2017 Aug;16(2):1298-1306.

Related compound libraries

This product is contained In the following compound libraries：

Oxidation-Reduction Compound Library Bioactive Compounds Library Max Polyphenolic Natural Product Library Anti-Tumor Natural Product Library Selected Plant-Sourced Compound Library Natural Product Library for HTS Antioxidant Compound Library Flavonoid Natural Product Library Natural Product Library Bioactive Compound Library

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Keywords

Flavanomarein 577-38-8 Others antioxidative PI3K antihypertensive Smad anti-hyperlipidemic 6-hydroxydopamine NF-κB TGF-β1 diabetic nephropathy inhibit Inhibitor AKT Syk antidiabetic inhibitor

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