keep away from direct sunlight,keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
TGFβ1-IN-1 is an orally active TGF-β1 inhibitor that inhibits the production of TGF-β1-induced fibrotic markers (α-SMA and fibronectin) and can be used for the study of cancer and autoimmune diseases.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | In stock | $ 92.00 |
Description | TGFβ1-IN-1 is an orally active TGF-β1 inhibitor that inhibits the production of TGF-β1-induced fibrotic markers (α-SMA and fibronectin) and can be used for the study of cancer and autoimmune diseases. |
In vitro | In HSCs (LX-2) cells, TGFβ1-IN-1 (20 μM; 24 or 72 hours) showed a survival rate of 77.5% and an inhibition rate of 30.3% for LX-2 cells. Additionally, it significantly inhibited the protein expression of fibronectin and α-SMA[1]. |
In vivo | In the CCl4-induced liver fibrosis model of C57BL/6J mice, TGFβ1-IN-1 (15 or 30 mg/kg; oral administration; daily; 3 weeks) significantly prevented CCl4-induced liver injury and reduced liver weight factor, serum ALT, AST, CHO, and TG levels[1]. |
Molecular Weight | 364.438 |
Formula | C22H24N2O3 |
CAS No. | 2348795-14-0 |
keep away from direct sunlight,keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 80 mg/mL (219.51 mM), Sonification is recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
TGFβ1-IN-1 2348795-14-0 Stem Cells TGF-beta/Smad inhibitor inhibit