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Search Result

Search Results for " i1 "

Targets

Others

45

Compounds

1

Natural Products

21

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T8955 PCNA-I1 Others
PCNA-I1 is an inhibitor targeting PCNA chromatin association in prostate cancer.
T25951 Phox-I1 Phox I1
Phox-I1 is a NOX2 inhibitor targeting the interactive site of p67phox with Rac GTPase.
T32089 HMS-I1 Hydrobromide HMS-I1 HBr
HMS-I1 Hydrobromide is a probe that works by destroying heterochromatin mediated transcriptional gene silencing and is used for studies of heterochromatin formation and function.
T36238 6α-Prostaglandin I1 6α-Prostaglandin I1
6α-Prostaglandin I1 (6α-PGI1) is a stable Prostaglandin I2 (PGI2) analog resistant to hydrolysis in aqueous solutions. 6α-PGI1 promotes cyclic AMP accumulation in human thyroid slices and cells in a concentration depende...
T36239 6β-Prostaglandin I1 6β-Prostaglandin I1
6β-PGI1 is a stable PGI2 analog resistant to hydrolysis in aqueous solutions. 6β-PGI1 has a much longer half-life than PGI2, but a greatly reduced molar potency for receptor mediated function. 6β-PGI1 has a Kact for aden...
T24394 LDN-0028574 SIRT1-I1,SIRT1-Inhibitor-I1,LDN-28574,LDN 0028574
LDN-0028574 is a SIRT1 inhibitor that also acts as an inhibitor of the human MDM2-p53 interaction.
T15500 HPi1 Others , Antibacterial
HPi1 is a selective and orally active antimicrobial against Helicobacter pylori (IC50: 0.24 μM and a MIC of 0.08-0.16 μg/mL). HPi1 is inactive against other Xaliproden, including the gut commensals, Lactobacillus reuteri...
T17350 ACBI1 Apoptosis , Epigenetic Reader Domain , PROTACs
ACBI1 is a potent PROTAC degrader of BAF ATPase subunits SMARCA2 and SMARCA4, also degrades the polybromo-associated BAF (PBAF) complex member PBRM1, with DC50s of 6 nM, 11 nM and 32 nM for SMARCA2, SMARCA4 and PBRM1 in ...
T16290 NIK SMI1 NF-κB
NIK SMI1 is an effective and selective NF-κB inducing kinase (NIK) inhibitor. It also inhibits NIK-catalyzed hydrolysis of ATP to ADP (IC50: 0.23±0.17 nM).
T9753 LEI110 Phospholipase
LEI110 is a potent Phospholipase A2, group XVI (PLA2G16) inhibitor with an Ki value of 20 nM. LEI110 is a selective pan-inhibitor of the HRASLS family of thiol hydrolases (i.e., PLA2G16, HRASLS2, RARRES3 and iNAT).
T9960 MCU-i11 Others
MCU-i11 is a novel negative modulator of the MCU, binding MICU1 and impairing muscle cell growth.
T6108 Ki16425 Debio 0719 LPA Receptor , LPL Receptor
Ki16425 (Debio 0719) is a competitive, potent and reversible antagonist to LPA1, LPA2 and LPA3 with Ki of 0.34 μM, 6.5 μM and 0.93 μM, respectively.
T2011 RKI1313 RKI 1313,RKI-1313 ROCK
RKI1313 (RKI-1313) was a selective inhibitor for ROCK-dependent signaling, cytoskeletal changes, anchorage-independent colony formation, migration, and invasion.
T6009 TAPI1 TAPI 1,TAPI,TAPI-1 MMP
TAPI1 (TAPI) , an ADAM17/TACE inhibitor, inhibits shedding of cytokine receptors.
T6347 Ki16198 LPA Receptor , LPL Receptor
Ki16198 is the methyl ester of Ki16425, which is a LPA antagonist and inhibits LPA1- and LPA3-induced inositol phosphate production with Ki of 0.34 μM and 0.93 μM, respectively, shows weaker inhibition for LPA2, no activ...
T3561 CPI1189 CPI-1189,REN-1189,CPI 1189 TNF
CPI1189 (REN-1189) is a TNF-a release inhibitor potentially for the treatment of sciatica and postherpetic neuralgia.
T6484 EI1 KB-145943,Ezh2 inhibitor Apoptosis , Histone Methyltransferase
EI1 (Ezh2 inhibitor) is a potent and selective EZH2 inhibitor with IC50 of 15 nM and 13 nM for EZH2 (WT) and EZH2 (Y641F), respectively.
T2439 O4I1 OCT
O4I1 is an effective Oct3/4 inducer.
T61016 EMI1 EGFR
EMI1 can be used in the mutant EGFR-associated, drug-resistant non-small-cell lung cancer(NSCLC) research. EMI1 is an inhibitor of EGFR L858R/T790M/C797S and EGFR ex19del/T790M/C797S [1].
T12235 NMDI14 Others
NMDI14 is an inhibitor of nonsense mediated RNA decay (NMD).
T67930L CWI1-2 HCL Apoptosis
CWI1-2 HCL is an effective IGF2BP2 inhibitor, which can induce apoptosis and differentiation by binding IGF2BP2 and inhibiting its interaction with M6A-modified target transcription, and has therapeutic effects on leukem...
T1833 NSI189 NSI-189,NSI 189 Others
NSI189 (NSI-189) is a nootropic and neurogenic research chemical derived from nicotinamide and pyrazine.
T5210 BAI1 Apoptosis , BCL
BAI1 (Bax channel blocker) is a potent inhibitor of Bax-mediated mitochondrial cytochrome C release (IC50: 0.52 μM).
T9588 JI130 Others
JI130 is able to impair the ability of Hes1 to repress transcription. JI130 treatment significantly reduced tumor volume in a murine pancreatic tumor xenograft model.
T41204 TAT-Gap19(I130A) TAT-Gap19(I130A)
TAT-Gap19(I130A) is a control peptide for TAT-Gap19, a Cx43 hemichannel blocker. TAT-Gap19(I130A) consists of TAT-GAP19 with a I130A amino acid residue change at a key residue for GAP19 activity. In C6 glioma cells expre...
T74402 FAP-PI3KI1
FAP-PI3KI1, a fibroblast-activated protein (FAP)-targeted PI3K inhibitor, selectively targets FAP-expressing human idiopathic pulmonary fibrosis (IPF) cells. It effectively inhibits collagen synthesis and reduces collage...
T10700 (+)-CBI-CDPI1 Others
(+)-CBI-CDPI1 is an enhanced functional analog of CC-1065. It is a DNA alkylating agent and an antibody-drug conjugates (ADCs) toxin.
T79199 F-CRI1 STING
F-CRI1, a potent STING agonist with a dissociation constant (K d) of 40.62 nM, is an 18F-labeled radioactive probe employed for visualizing STING in the tumor microenvironment [1].
T67930 CWI1-2 Apoptosis
CWI1-2 is a potent IGF2BP2 inhibitor that inhibits its interaction with M6A-modified target transcripts by binding IGF2BP2. CWI1-2 has anti-leukemic activity and can induce apoptosis and differentiation.
T38377 ADTL-EI1712 ADTL-EI1712
ADTL-EI1712 is a dual inhibitor of ERK1 and ERK5 (IC50s = 40.43 and 64.5 nM, respectively).1It reduces ERK1 and ERK5 activity by 93.5% and 89.4%, respectively, but also inhibits ERK2 activity by 92.7%, in a panel of 100 ...
T34089 PLI14 PLI-14,PLI 14
PLI14 is a bioactive chemical.
T69866 PhotoGBI1
photoGBI1 is a photocontrol inhibitor of the voltage-gated proton channel Hv1.
T62692 ML-SI1
ML-SI1, a racemic mixture of diastereoisomers, is a TRPML inhibitor and acts on TRPML1 (IC50: 15 μM).
T23788 BI1002494 BI 1002494,BI-1002494
BI1002494 is an effective and selective Syk inhibitor.
T74970 306Oi10
306Oi10, a branched-chain ionizable lipidoid, facilitates the construction of lipid nanoparticles (LNPs) for messenger RNA delivery [1].
T80402 Api137
Api137 is an antimicrobial peptide that disrupts bacterial growth by blocking translation processes. Specifically, it inhibits protein synthesis through the entrapment of release factors on the 70S ribosome after the hyd...
T12195 NCI172112 NSC268497,NSC172112 Others
NCI172112 is is used to develop antitumor agents effective against CNS tumors.
T27810 LEI105 LEI-105,LEI 105
LEI105 is a potent, highly selective, and reversible inhibitor of DAGL-α and DAGL-β.
T38392 JAMI1001A
JAMI1001A is a positive allosteric modulator of the AMPA receptor, effectively modulating the deactivation and desensitization of both flip and flop receptor isoforms.
T6641 Rilmenidine Phosphate Apoptosis , Adrenergic Receptor , Autophagy , Imidazoline Receptor
Rilmenidine Phosphate is a selective I(1) imidazoline receptor agonist, used to treat hypertension.
T22760 Efaroxan hydrochloride Others
α2 adrenoceptor antagonist and imidazoline I1 receptor ligand
T27155 Dexisometheptene TNX 201,TNX-201,(R)-Isometheptene,TNX201
Dexisometheptene is an antimigraine drug candidate. Dexisometheptene significantly increases the pain threshold of acute pain response, and potently and selectively binds to receptors in the central nervous system known ...
T63968 AZ14145845
AZ14145845 is an in vivo potent and highly selective type I1/2 Mer/Axl bispecific kinase inhibitor.
T21911 Rilmenidine hemifumarate Rilmenidine (hemifumarate),S-3341 hemifumarate Apoptosis , Imidazoline Receptor
Rilmenidine hemifumarate (S-3341 hemifumarate) is a novel, orally active and selective I1 imidazoline receptor and α2-adrenoceptor agonist that induces autophagy, regulates the proliferation of leukaemia cells, stimulate...
T40869 Moxonidine hydrochloride BDF5895hydrochloride
Moxonidine Hydrochloride serves as a selective agonist for the imidazoline receptor subtype 1 and functions as an antihypertensive agent. It primarily acts within the central nervous system and demonstrates a significant...

Compounds

PCNA-I1
T8955
Synonym:
Target: Others
Phox-I1
T25951
Synonym: Phox I1
Target:
HMS-I1 Hydrobromide
T32089
Synonym: HMS-I1 HBr
Target:
6α-Prostaglandin I1
T36238
Synonym: 6α-Prostaglandin I1
Target:
6β-Prostaglandin I1
T36239
Synonym: 6β-Prostaglandin I1
Target:
LDN-0028574
T24394
Synonym: SIRT1-I1,SIRT1-Inhibitor-I1,LDN-28574,LDN 0028574
Target:
HPi1
T15500
Synonym:
Target: Others, Antibacterial
ACBI1
T17350
Synonym:
Target: Apoptosis, Epigenetic Reader Domain, PROTACs
NIK SMI1
T16290
Synonym:
Target: NF-κB
LEI110
T9753
Synonym:
Target: Phospholipase
MCU-i11
T9960
Synonym:
Target: Others
Ki16425
T6108
Synonym: Debio 0719
Target: LPA Receptor, LPL Receptor
RKI1313
T2011
Synonym: RKI 1313,RKI-1313
Target: ROCK
TAPI1
T6009
Synonym: TAPI 1,TAPI,TAPI-1
Target: MMP
Ki16198
T6347
Synonym:
Target: LPA Receptor, LPL Receptor
CPI1189
T3561
Synonym: CPI-1189,REN-1189,CPI 1189
Target: TNF
EI1
T6484
Synonym: KB-145943,Ezh2 inhibitor
Target: Apoptosis, Histone Methyltransferase
O4I1
T2439
Synonym:
Target: OCT
EMI1
T61016
Synonym:
Target: EGFR
NMDI14
T12235
Synonym:
Target: Others
CWI1-2 HCL
T67930L
Synonym:
Target: Apoptosis
NSI189
T1833
Synonym: NSI-189,NSI 189
Target: Others
BAI1
T5210
Synonym:
Target: Apoptosis, BCL
JI130
T9588
Synonym:
Target: Others
TAT-Gap19(I130A)
T41204
Synonym: TAT-Gap19(I130A)
Target:
FAP-PI3KI1
T74402
Synonym:
Target:
(+)-CBI-CDPI1
T10700
Synonym:
Target: Others
F-CRI1
T79199
Synonym:
Target: STING
CWI1-2
T67930
Synonym:
Target: Apoptosis
ADTL-EI1712
T38377
Synonym: ADTL-EI1712
Target:
PLI14
T34089
Synonym: PLI-14,PLI 14
Target:
photoGBI1
T69866
Synonym:
Target:
ML-SI1
T62692
Synonym:
Target:
BI1002494
T23788
Synonym: BI 1002494,BI-1002494
Target:
306Oi10
T74970
Synonym:
Target:
Api137
T80402
Synonym:
Target:
NCI172112
T12195
Synonym: NSC268497,NSC172112
Target: Others
LEI105
T27810
Synonym: LEI-105,LEI 105
Target:
JAMI1001A
T38392
Synonym:
Target:
Rilmenidine Phosphate
T6641
Synonym:
Target: Apoptosis, Adrenergic Receptor, Autophagy, Imidazoline Receptor
Efaroxan hydrochloride
T22760
Synonym:
Target: Others
Dexisometheptene
T27155
Synonym: TNX 201,TNX-201,(R)-Isometheptene,TNX201
Target:
AZ14145845
T63968
Synonym:
Target:
Rilmenidine hemifumarate
T21911
Synonym: Rilmenidine (hemifumarate),S-3341 hemifumarate
Target: Apoptosis, Imidazoline Receptor
Moxonidine hydrochloride
T40869
Synonym: BDF5895hydrochloride
Target:
Cat No. Product Name Synonyms Targets
T3158 Harmane Loturine,Harman,Aribine Adrenergic Receptor , Monoamine Oxidase , Imidazoline Receptor
Harmane (Loturine) is a bio-active β-Carboline and monoamine oxidase inhibitor found in coffee and tobacco smoke.

Natural Products

Harmane
T3158
Synonym: Loturine,Harman,Aribine
Target: Adrenergic Receptor, Monoamine Oxidase, Imidazoline Receptor

Recombinant Proteins

Species：
Human (13)
Mouse (3)
H1N1 (2)
H1N8 (1)
H5N2 (1)
MPXV (1)
Expression System：
E. coli (10)
HEK293 (6)
Baculovirus (2)
Baculovirus-Insect Cells (2)
Human Cells (1)
Tag：
His (10)
C-6His (2)
N-terminal 10xHis-tagged (2)
N-terminal 6xHis-SUMO-tagged (2)
N-terminal 6xHis-tagged (2)
N-terminal 10xHis-Flag-tagged and C-terminal Myc-tagged (1)
N-terminal 10xHis-tagged and C-terminal Myc-tagged (1)
mFc (1)
Cat No. Product Name Species Expression System
TMPY-01241 Neuroserpin Protein, Human, Recombinant (His) Human HEK293
Neuroserpin, also known as Protease inhibitor 12 and SERPINI1, is a secreted protein that belongs to the serpin family. Neuroserpin is a serine protease inhibitor that inhibits plasminogen activators and plasmin but not ...
TMPY-02628 Neuroserpin Protein, Mouse, Recombinant (His) Mouse HEK293
Neuroserpin, also known as Protease inhibitor 12 and SERPINI1, is a secreted protein that belongs to the serpin family. Neuroserpin is a serine protease inhibitor that inhibits plasminogen activators and plasmin but not ...
TMPJ-00528 PPP1R1A Protein, Human, Recombinant (His) Human E. coli
Protein Phosphatase 1 Regulatory Subunit 1A (PPP1R1A) is an inhibitor of protein-phosphatase 1. PPP1R1A is a cellular regulator of eIF2 alpha phosphorylation. In hormonal control of glycogen metabolism, IPP-1 protein pla...
TMPJ-01464 IL-2 Superkine Protein, Human, Recombinant (L100F, R101D, L105V, I106V, I112F) Human Human Cells
Interleukin-2(IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system，belongs to the IL-2 family. It is a powerful immunoregulatory lymphokine produced by T-cells in response to antigenic or m...
TMPY-01382 Influenza A H1N1 (A/Puerto Rico/8/34/Mount Sinai) Nucleoprotein/NP Protein (I116M, His) H1N1 Baculovirus-Insect Cells
Influenza viral nucleoprotein (NP) plays a critical role in virus replication and host adaptation. Nucleoprotein (NP) is an essential multifunctional protein that encapsidates the viral genome and functions as an adapter...
TMPH-02321 GLI1 Protein, Human, Recombinant (His) Human E. coli
Acts as a transcriptional activator. Binds to the DNA consensus sequence 5'-GACCACCCA-3'. Regulates the transcription of specific genes during normal development. Plays a role in craniofacial development and digital deve...
TMPY-02230 Influenza A H5N2 (A/ostrich/South Africa/AI1091/2006) Hemagglutinin/HA1 Protein (His) H5N2 HEK293
The influenza viral Hemagglutinin (HA) protein is a homotrimer with a receptor binding pocket on the globular head of each monomer.HA has at least 18 different antigens. These subtypes are named H1 through H18.HA has two...
TMPY-00526 VTI1A Protein, Human, Recombinant (mFc) Human HEK293
Evolutionarily conserved SNARE (soluble N-ethylmaleimide sensitive factor attachment protein receptors) proteins form a complex that drives membrane fusion in eukaryotes. VTI1A and VTI1B are the only members of their SNA...
TMPH-01196 DYNC1I1 Protein, Human, Recombinant (His) Human Baculovirus
DYNC1I1 Protein, Human, Recombinant (His) is expressed in Baculovirus.
TMPH-01609 LGI1 Protein, Human, Recombinant (His & Myc) Human E. coli
Regulates voltage-gated potassium channels assembled from KCNA1, KCNA4 and KCNAB1. It slows down channel inactivation by precluding channel closure mediated by the KCNAB1 subunit. Ligand for ADAM22 that positively regula...
TMPH-02220 SPI1 Protein, Human, Recombinant (His) Human E. coli
Binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA-3') that can act as a lymphoid-specific enhancer. This protein is a transcriptional activator that may be specifically involved in the differentiation or activat...
TMPH-01179 COX4I1 Protein, Human, Recombinant (His & SUMO) Human E. coli
COX4I1 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli.
TMPY-06539 Monkeypox Virus (MPXV) I1L Protein (His) MPXV E. coli
Monkeypox Virus (MPXV) I1L Protein (His) is expressed in E. coli with His tag. The predicted molecular weight is 37.71 kDa.
TMPY-06140 Influenza A H1N1 (A/Puerto Rico/8/34/Mount Sinai) Nucleoprotein/NP Protein (I116M, His), Biotinylated H1N1 Baculovirus-Insect Cells
Influenza viral nucleoprotein (NP) plays a critical role in virus replication and host adaptation. Nucleoprotein (NP) is an essential multifunctional protein that encapsidates the viral genome and functions as an adapter...
TMPY-04072 VTI1A Protein, Human, Recombinant (His) Human HEK293
Evolutionarily conserved SNARE (soluble N-ethylmaleimide sensitive factor attachment protein receptors) proteins form a complex that drives membrane fusion in eukaryotes. VTI1A and VTI1B are the only members of their SNA...
TMPY-06912 PU.1/SPI1 Protein, Mouse, Recombinant (His) Mouse E. coli
SPI1 (also known as PU.1) is a dominant but transient regulator in early T-cell precursors and a potent transcriptional controller of developmentally important pro-T-cell genes. SPI1 is an essential transcription factor ...
TMPH-01264 PELI1 Protein, Human, Recombinant (His) Human Baculovirus
E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Me...
TMPH-02306 VTI1B Protein, Human, Recombinant (His & SUMO) Human E. coli
V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusi...
TMPH-02956 TNNI1 Protein, Mouse, Recombinant (Flag & His & Myc) Mouse E. coli
Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
TMPY-00101 Influenza A H1N8 (A/Egyptian goose/South Africa/AI1448/2007) Hemagglutinin/HA1 Protein (His) H1N8 HEK293
The influenza viral Hemagglutinin (HA) protein is a homotrimer with a receptor binding pocket on the globular head of each monomer.HA has at least 18 different antigens. These subtypes are named H1 through H18.HA has two...
TMPY-06917 PU.1/SPI1 Protein, Human, Recombinant (His) Human E. coli
SPI1 (also known as PU.1) is a dominant but transient regulator in early T-cell precursors and a potent transcriptional controller of developmentally important pro-T-cell genes. SPI1 is an essential transcription factor ...
Neuroserpin Protein, Human, Recombinant (His)
TMPY-01241
Species: Human
Expression System: HEK293
Neuroserpin Protein, Mouse, Recombinant (His)
TMPY-02628
Species: Mouse
Expression System: HEK293
PPP1R1A Protein, Human, Recombinant (His)
TMPJ-00528
Species: Human
Expression System: E. coli
IL-2 Superkine Protein, Human, Recombinant (L100F, R101D, L105V, I106V, I112F)
TMPJ-01464
Species: Human
Expression System: Human Cells
Influenza A H1N1 (A/Puerto Rico/8/34/Mount Sinai) Nucleoprotein/NP Protein (I116M, His)
TMPY-01382
Species: H1N1
Expression System: Baculovirus-Insect Cells
GLI1 Protein, Human, Recombinant (His)
TMPH-02321
Species: Human
Expression System: E. coli
Influenza A H5N2 (A/ostrich/South Africa/AI1091/2006) Hemagglutinin/HA1 Protein (His)
TMPY-02230
Species: H5N2
Expression System: HEK293
VTI1A Protein, Human, Recombinant (mFc)
TMPY-00526
Species: Human
Expression System: HEK293
DYNC1I1 Protein, Human, Recombinant (His)
TMPH-01196
Species: Human
Expression System: Baculovirus
LGI1 Protein, Human, Recombinant (His & Myc)
TMPH-01609
Species: Human
Expression System: E. coli
SPI1 Protein, Human, Recombinant (His)
TMPH-02220
Species: Human
Expression System: E. coli
COX4I1 Protein, Human, Recombinant (His & SUMO)
TMPH-01179
Species: Human
Expression System: E. coli
Monkeypox Virus (MPXV) I1L Protein (His)
TMPY-06539
Species: MPXV
Expression System: E. coli
Influenza A H1N1 (A/Puerto Rico/8/34/Mount Sinai) Nucleoprotein/NP Protein (I116M, His), Biotinylated
TMPY-06140
Species: H1N1
Expression System: Baculovirus-Insect Cells
VTI1A Protein, Human, Recombinant (His)
TMPY-04072
Species: Human
Expression System: HEK293
PU.1/SPI1 Protein, Mouse, Recombinant (His)
TMPY-06912
Species: Mouse
Expression System: E. coli
PELI1 Protein, Human, Recombinant (His)
TMPH-01264
Species: Human
Expression System: Baculovirus
VTI1B Protein, Human, Recombinant (His & SUMO)
TMPH-02306
Species: Human
Expression System: E. coli
TNNI1 Protein, Mouse, Recombinant (Flag & His & Myc)
TMPH-02956
Species: Mouse
Expression System: E. coli
Influenza A H1N8 (A/Egyptian goose/South Africa/AI1448/2007) Hemagglutinin/HA1 Protein (His)
TMPY-00101
Species: H1N8
Expression System: HEK293
PU.1/SPI1 Protein, Human, Recombinant (His)
TMPY-06917
Species: Human
Expression System: E. coli
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