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LEI110

Catalog No. T9753 CAS 2313525-90-3

LEI110 is a potent <a href="/target/Phospholipase" style="display: inline; color: #c13a36">Phospholipase</a> A2, group XVI (PLA2G16) inhibitor with an Ki value of 20 nM. LEI110 is a selective pan-inhibitor of the HRASLS family of thiol hydrolases (i.e., PLA2G16, HRASLS2, RARRES3 and iNAT).

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LEI110, CAS 2313525-90-3

Pack Size	Availability	Price/USD
1 mg	In stock	$ 119.00
5 mg	In stock	$ 239.00
10 mg	In stock	$ 347.00
25 mg	In stock	$ 725.00
50 mg	In stock	$ 1,157.00

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	LEI110 is a potent Phospholipase A2, group XVI (PLA2G16) inhibitor with an Ki value of 20 nM. LEI110 is a selective pan-inhibitor of the HRASLS family of thiol hydrolases (i.e., PLA2G16, HRASLS2, RARRES3 and iNAT).
Targets&IC50	PLA2G16:20 nM(Ki)
In vitro	LEI110 reduces cellular arachidonic acid levels in PLA2G16-overexpressing U2OS cells and oleic acid-induced steatosis in human HepG2 cells[1].

Molecular Weight	456.465
Formula	C25H23F3N2O3
CAS No.	2313525-90-3

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Zhou J, et al. Activity-Based Protein Profiling Identifies α-Ketoamides as Inhibitors for Phospholipase A2 Group XVI. ACS Chem Biol. 2019 Feb 15;14(2):164-169.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Metabolism Compound Library Bioactive Compound Library Bioactive Compounds Library Max

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

LEI110 2313525-90-3 Metabolism Phospholipase HepG2 cells inhibit thiol hydrolases Inhibitor LEI-110 lipolysis LEI 110 inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.