Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PCNA-I1 is an inhibitor targeting PCNA chromatin association in prostate cancer.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 97.00 | |
5 mg | In stock | $ 247.00 | |
10 mg | In stock | $ 372.00 | |
25 mg | In stock | $ 629.00 | |
50 mg | In stock | $ 896.00 | |
100 mg | In stock | $ 1,220.00 | |
500 mg | In stock | $ 2,450.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 265.00 |
Description | PCNA-I1 is an inhibitor targeting PCNA chromatin association in prostate cancer. |
In vitro | PCNA-I1 induced DNA damage and apoptosis in both LNCaP and PC-3 cells and enhanced DNA damage and apoptosis triggered by cisplatin.?PCNA-I1 also induced autophagy in PC-3 cells.?A short-term pretreatment with PCNA-I1 reduced colony formation by 50% in both cell lines.[1] |
In vivo | Intravenous administrations of PCNA-I1 significantly retarded growth of LNCaP tumors of in nude mice without causing detectable effects on mouse body weight and hematology profiles[1]. |
Molecular Weight | 310.37 |
Formula | C17H14N2O2S |
CAS No. | 444930-42-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 3.1 mg/mL (10 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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PCNA-I1 444930-42-1 Others PCNA-I-1 DNA/RNA Synthesis inhibit PCNAI1 Inhibitor PCNA I1 inhibitor