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MCU-i11

Name: MCU-i11
Brand: TargetMol
SKU: T9960
Price: 163 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T9960Cas No. 902903-59-7

MCU-i11 is a novel negative modulator of the MCU, binding MICU1 and impairing muscle cell growth.

MCU-i11

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Purity: 98.3%

Catalog No. T9960Cas No. 902903-59-7

MCU-i11 is a novel negative modulator of the MCU, binding MICU1 and impairing muscle cell growth.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$163	In Stock	In Stock
5 mg	$378	In Stock	In Stock
10 mg	$538	In Stock	In Stock
25 mg	$892	In Stock	In Stock
50 mg	$1,220	-	In Stock
100 mg	$1,650	-	In Stock
1 mL x 10 mM (in DMSO)	$445	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.3%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	MCU-i11 is a novel negative modulator of the MCU, binding MICU1 and impairing muscle cell growth.
In vitro	Mitochondrial Ca2+ uptake in mouse embryonic fibroblasts (MEFs), MDA-MB-231, and HEK293T cell lines were measured upon treatment with 10 μM compound. MCU-i11 reduced mitochondrial Ca2+ uptake in all tested cell lines, indicating the existence of a conserved mechanism. MCU-i11 had no effect on cell viability. [1]

Chemical Properties

Molecular Weight	532.61
Formula	C₂₈H₂₈N₄O₅S
Cas No.	902903-59-7
Smiles	O=C1C2=C(N(CC(NC3=CC=C(OCC)C=C3)=O)C(=O)N1CC4=CC=CC=C4)SC5=C2CCN(C(C)=O)C5
Relative Density.	1.374 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 127.5 mg/mL (239.39 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8775 mL	9.3877 mL	18.7755 mL	93.8773 mL
5 mM	0.3755 mL	1.8775 mL	3.7551 mL	18.7755 mL
10 mM	0.1878 mL	0.9388 mL	1.8775 mL	9.3877 mL
20 mM	0.0939 mL	0.4694 mL	0.9388 mL	4.6939 mL
50 mM	0.0376 mL	0.1878 mL	0.3755 mL	1.8775 mL
100 mM	0.0188 mL	0.0939 mL	0.1878 mL	0.9388 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc