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NIK SMI1

Catalog No. T16290 CAS 1660114-31-7

NIK SMI1 is an effective and selective NF-κB inducing kinase (NIK) inhibitor. It also inhibits NIK-catalyzed hydrolysis of ATP to ADP (IC50: 0.23±0.17 nM).

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NIK SMI1, CAS 1660114-31-7

Pack Size	Availability	Price/USD
1 mg	In stock	$ 163.00
5 mg	In stock	$ 413.00
10 mg	In stock	$ 618.00
25 mg	In stock	$ 985.00
50 mg	In stock	$ 1,330.00
100 mg	In stock	$ 1,790.00
1 mL * 10 mM (in DMSO)	In stock	$ 455.00

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Purity: 99.99%

Purity: 99.48%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	NIK SMI1 is an effective and selective NF-κB inducing kinase (NIK) inhibitor. It also inhibits NIK-catalyzed hydrolysis of ATP to ADP (IC50: 0.23±0.17 nM).
In vitro	NIK SMI1 inhibits the expression of NIK SMI1 response element regulated firefly luciferase reporter gene in HEK293 cells (IC50: 34±6 nM). NIK SMI1 inhibits BAFF-induced B cell (mouse) survival in vitro with an IC50 of 373±64 nM. Consistent with expectations for a NIK inhibitor, NIK SMI1 is shown to inhibit nuclear translocation of p52 (RelB) (IC50=70 nM).
In vivo	The pharmacology of NIK SMI1 is examined in SD rat, CD-1 mouse, beagle, and cynomologous monkey with 20, 32, 18, and 7.8 mL/kg per min, respectively. The volume of distribution (Vd, L/kg) is 1.35, 1.58, 0.778, and 1.39, respectively. C57BL/6 mice are treated twice daily for 7 days with orally administered NIK SMI1 or with three injections of recombinant BAFF receptor fusion protein (Br3- mIgG2a) over the course of the 7-day experiment as a positive control .

Molecular Weight	365.38
Formula	C20H19N3O4
CAS No.	1660114-31-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (273.69 mM), Sonification is recommended.

References and Literature

1. Blaquiere N, et al. Scaffold-Hopping Approach To Discover Potent, Selective, and Efficacious Inhibitors of NF-κB Inducing Kinase. J Med Chem. 2018 Aug 9;61(15):6801-6813.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Breast Cancer Compound Library Anti-Cancer Compound Library Bioactive Compound Library Antioxidant Compound Library Antidepressant Compound Library Transcription Factor-Targeted Compound Library Anti-Ovarian Cancer Compound Library NF-κB Signaling Compound Library Covalent Inhibitor Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

NIK SMI1 1660114-31-7 NF-Κb NF-κB Nuclear factor-κB NIK SMI 1 Nuclear factor-kappaB inhibit Inhibitor NIK SMI-1 inhibitor

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