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BAI1

Catalog No. T5210   CAS 335165-68-9

BAI1 (Bax channel blocker) is a potent inhibitor of Bax-mediated mitochondrial cytochrome C release (IC50: 0.52 μM).

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BAI1 Chemical Structure
BAI1, CAS 335165-68-9
Pack Size Availability Price/USD Quantity
1 mg In stock $ 34.00
2 mg In stock $ 48.00
5 mg In stock $ 80.00
10 mg In stock $ 128.00
25 mg In stock $ 253.00
50 mg In stock $ 463.00
100 mg In stock $ 682.00
1 mL * 10 mM (in DMSO) In stock $ 89.00
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Purity: 99.58%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description BAI1 (Bax channel blocker) is a potent inhibitor of Bax-mediated mitochondrial cytochrome C release (IC50: 0.52 μM).
Targets&IC50 Bax:0.52 μM
In vitro V-9302 inhibited ASCT2-mediated glutamine uptake in human cells in a concentration-dependent fashion and exhibited a 100-fold improvement in potency (IC50 V-9302 = 9.6 μM) over gamma-L-glutamyl-p-nitroanilide (GPNA; IC50 = 1000 μM). The EC50 concentration
Molecular Weight 467.2
Formula C19H21Br2N3O
CAS No. 335165-68-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: Insoluble

DMSO: 15 mg/mL (32.1 mM)

TargetMolReferences and Literature

1. Bombrun A, et al. 3,6-dibromocarbazole piperazine derivatives of 2-propanol as first inhibitors of cytochrome c release via Bax channel modulation. J Med Chem. 2003 Oct 9;46(21):4365-8. 2. Garner TP, et al. Small-molecule allosteric inhibitors of BAX. Nat Chem Biol. 2019 Apr;15(4):322-330.

Related compound libraries

This product is contained In the following compound libraries:
NO PAINS Compound Library Anti-Aging Compound Library Bioactive Compound Library Target-Focused Phenotypic Screening Library Cuproptosis Compound Library Inhibitor Library Anti-Cancer Compound Library Bioactive Compounds Library Max Mitochondria-Targeted Compound Library Apoptosis Compound Library

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Keywords

BAI1 335165-68-9 Apoptosis BCL Inhibitor mitochondrial cell inhibit effector critical BAI-1 BAX death Bcl-2 Family pathway BAI 1 inhibitor

 

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