Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ACBI1 is a potent PROTAC degrader of BAF ATPase subunits SMARCA2 and SMARCA4, also degrades the polybromo-associated BAF (PBAF) complex member PBRM1, with DC50s of 6 nM, 11 nM and 32 nM for SMARCA2, SMARCA4 and PBRM1 in MV-4-11 cells, respectively. ACBI1 is composed of a bromodomain ligand, a linker, and the E3 ubiquitin ligase VHL. ACBI1 can induce anti-proliferative effects and apoptosis.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 98.00 | |
5 mg | In stock | $ 237.00 | |
10 mg | In stock | $ 382.00 | |
25 mg | In stock | $ 639.00 | |
50 mg | In stock | $ 913.00 | |
100 mg | In stock | $ 1,230.00 |
Description | ACBI1 is a potent PROTAC degrader of BAF ATPase subunits SMARCA2 and SMARCA4, also degrades the polybromo-associated BAF (PBAF) complex member PBRM1, with DC50s of 6 nM, 11 nM and 32 nM for SMARCA2, SMARCA4 and PBRM1 in MV-4-11 cells, respectively. ACBI1 is composed of a bromodomain ligand, a linker, and the E3 ubiquitin ligase VHL. ACBI1 can induce anti-proliferative effects and apoptosis. |
Targets&IC50 | SMARCA2:6 nM (DC50), SMARCA4:11 nM (DC50), PBRM1:32 nM (DC50) |
Molecular Weight | 936.1 |
Formula | C49H58FN9O7S |
CAS No. | 2375564-55-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (106.83 mM)
You can also refer to dose conversion for different animals. More
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ACBI1 2375564-55-7 Apoptosis Chromatin/Epigenetic PROTAC Epigenetic Reader Domain PROTACs anti-proliferative ACBI 1 Inhibitor ACBI-1 inhibit inhibitor