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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T17157 | TRAF-STOP inhibitor 6877002 | CD40-TRAF6 inhibitor | NF-κB |
TRAF-STOP inhibitor 6877002 (CD40-TRAF6 inhibitor), is a selective inhibitor of CD40-TRAF6 interaction. TRAF-STOP 6877002 reduces leukocyte recruitment, and reduces macrophage activation; reduces macrophage proliferation... | |||
T76830 | Teneliximab | Chi220,Anti-Human CD40 Recombinant Antibody,BMS 224819 | TNF |
Teneliximab (Chi220) is a chimeric monoclonal antibody and a tumor necrosis factor receptor superfamily member 5 (CD40) inhibitor that blocks CD40-CD40L interactions.Teneliximab exerts partial agonist activity through CD... | |||
T78312 | Cifurtilimab | SEA-CD40 | |
Cifurtilimab (SEA-CD40), a nonfucosylated humanized IgG1 monoclonal antibody with agonistic properties, targets the CD40 receptor and demonstrates antitumor activities [1] [2]. | |||
T82858 | Bleselumab | ASKP 1240,Anti-Human CD40 Recombinant Antibody | |
Bleselumab (ASKP 1240), a human anti-CD40 monoclonal antibody (mAb), exhibits high-affinity binding to CD40 (Kd: 0.24 nM) and hinders immune responses by impeding the CD40-CD40L interaction, thereby preventing organ tran... | |||
T9926 | Omalizumab | Others | |
Omalizumab is a recombinant humanized monoclonal antibody against human immunoglobulin E IgE) | |||
T11096 | DRI-C21045 | NF-κB | |
Dri-c21045 showed concentration-dependent inhibition of NF- B activation and all CD40L induced by B cell proliferation. IC50 was 17.1 M and 4.5 M, respectively.Dri-c21045 is an effective selective inhibitor of CD40-CD40L... | |||
T79194 | DRI-C25441 | ||
DRI-C25441 is a potent inhibitor of the CD40-CD40L interaction, exhibiting an IC50 value of 0.36 μM, and is capable of suppressing the immune response triggered by alloantigen [1]. | |||
T77035 | Inezetamab | ||
Inezetamab is a bispecific anti- CD40 and anti- MSLN IgG1 monoclonal antibody [1] . | |||
T73865 | (Rac)-BIO8898 | ||
(Rac)-BIO8898 is a chemical compound that serves as an inhibitor of the co-stimulatory interaction between CD40 and CD154. It effectively prevents CD154 from binding to CD40-Ig, demonstrating an inhibitory concentration ... | |||
T82615 | Dalnicastobart | LVGN-7409 | |
Dalnicastobart (LVGN-7409) is a human IgG1κ monoclonal antibody that specifically targets CD40, also known as TNFRSF5 [1]. | |||
T73866 | BIO8898 | ||
BIO8898, a potent inhibitor of the CD40-CD154 interaction, effectively prevents soluble CD40L from binding to CD40-Ig, demonstrating an inhibitory concentration (IC 50) value of 25 µM. Additionally, BIO8898 suppresses CD... | |||
T76729 | Lucatumumab | ||
Lucatumumab (HCD122), a fully human anti-CD40 antagonist monoclonal antibody, effectively inhibits CD40/CD40L-mediated signaling and promotes antibody-dependent cell-mediated cytotoxicity (ADCC) for tumor cell clearance.... | |||
T24808 | SMI-6860766 | TRAFSTOP 6860766,TRAF-STOP 6860766,SMI 6860766,TRAFSTOP6860766,SMI6860766 | |
SMI-6860766 is a CD40-Traf6 interactions blocker that acts by ameliorating the complications of diet-induced obesity in mice. | |||
T70214 | BMS-986202 | ||
BMS-986202 is a novel Tyk2 inhibitor, binding to Tyk2 JH2, showing efficacies for IL-23-driven acanthosis, anti-CD40-induced colitis, and spontaneous lupus. | |||
T61810 | Anti-inflammatory agent 16 | ||
Anti-inflammatory agent 16 (compound 14) is a highly effective peptidomimetic with potent anti-inflammatory properties. It effectively reduces the expression levels of TNFα, NO, CD40, and CD86 [1]. | |||
T78251 | Sotigalimab | ||
Sotigalimab, a CD40 agonistic monoclonal antibody, is utilized in research targeting metastatic pancreatic adenocarcinoma [1]. | |||
T78250 | Selicrelumab | ||
Selicrelumab, an agonist CD40 antibody, modifies the tumor microenvironment and is utilized in pancreatic cancer research and neoadjuvant studies [1]. | |||
T77143 | Ravagalimab | ||
Ravagalimab (ABBV-323), a CD40 antagonist with an EC50 of 3.7 nM, is utilized in the research of Crohn's disease [1]. | |||
T77013 | Frexalimab | ||
Frexalimab (SAR441344; INX-021), a monoclonal antibody that targets the CD40 ligand (CD40L), shows promise for research in multiple sclerosis [1]. | |||
T82320 | Giloralimab | ABBV-927 | |
Giloralimab (ABBV-927), an agonistic monoclonal antibody targeting CD40, exhibits potent activity and is being investigated for potential application in cancer research [1] [2]. | |||
T79193 | DRI-C21041 | ||
DRI-C21041 is a potent inhibitor of the CD40/CD40L interaction, demonstrating an inhibitory concentration 50 (IC50) value of 0.31 μM. It effectively suppresses the immune response triggered by alloantigen [1]. | |||
T78198 | DRI-C21041 (DIEA) | ||
DRI-C21041 DIEA serves as an inhibitor of CD40/CD40L interaction, exhibiting an inhibitory concentration (IC50) of 0.31 μM. It effectively suppresses the immune response triggered by alloantigen [1]. | |||
T30669 | C.I. Mordant Brown 1 | NSC-326197,NSC 326197,NSC326197 | |
C.I. Mordant Brown 1 is an azo dye with λmax of 373 nm, 487 nm (2nd).C.I. Mordant Brown 1 also inhibits CD40-CD154 co-stimulation of protein-protein interactions. | |||
T77043 | Iscalimab | ||
Iscalimab (CFZ-533), a non-depleting IgG1 monoclonal antibody that targets CD40 with a dissociation constant (K D) of 0.3 nM, is utilized in the research of Graves' hyperthyroidism and autoimmune diseases [1] [2] [3]. | |||
T76984 | Tecaginlimab | ||
Tecaginlimab (BNT-312), an Fc-inert bispecific antibody, is designed for the dual targeting and conditional activation of CD40 and 4-1BB, aiming to improve the priming and reactivation of tumor-specific immunity [1]. | |||
T76677 | Dacetuzumab | ||
Dacetuzumab (SGN-40), a humanized IgG1 anti-CD40 monoclonal antibody, exhibits anti-lymphoma activity by inducing tumor cell death through immune effector functions (antibody-dependent cellular cytotoxicity and phagocyto... | |||
T75130 | Glucocorticoid receptor agonist-1 phosphate Ala-Ala-Br | ||
Glucocorticoid Receptor Agonist-1 Phosphate Ala-Ala-Br is a drug-linker conjugate for antibody-drug conjugates (ADCs), serving as a reaction reagent in the creation of anti-CD40 antibody agent conjugates [1]. | |||
T75016 | Glucocorticoid receptor agonist-1 phosphate Ala-Ala-Mal | ||
Glucocorticoid Receptor Agonist-1 Phosphate Ala-Ala-Mal functions as a glucocorticoid receptor agonist, utilized in the formulation of anti-CD40 antibody agent conjugates (ADC). It serves as a research tool for exploring... | |||
T81022 | Tegoprubart | ||
Tegoprubart is a monoclonal antibody targeting CD40 ligand (CD40L), which plays a critical role in costimulation. By inhibiting CD40L, it diminishes both cellular and antibody-mediated immune responses, fostering a more ... | |||
T76834 | Toralizumab | ||
Toralizumab (IDEC-131), a humanized monoclonal antibody (mAb) directed against CD40L (CD154), consists of human gamma 1 heavy chains and human kappa light chains. Specifically targeting CD40L on T cells, it inhibits CD40... | |||
T82954 | ATAC21 | ||
ATAC21 is a linker-immune-stimulatory compound created by conjugating a noncleavable maleimide-PEG4 linker, which includes a succinimide group, with an immune-stimulatory agent. This compound can be further conjugated wi... | |||
T77090 | Mitazalimab | ||
Mitazalimab (ADC-1013; JNJ-64457107) is an FcγR-dependent CD40 agonist that exhibits directed activity against tumors. By activating antigen-presenting cells, such as dendritic cells (DC), it triggers the initiation of t... | |||
T37787 | 10-Nitrolinoleic acid | ||
10-Nitrolinoleate is the product of nitration of linoleate by NO-derived reactive species. Other nitrolinoleates detected in human plasma and urine include 9-, 12-, and 13-nitrolinoleate. Nitrolinoleates activate peroxis... | |||
T36984 | Cyclic di-IMP (sodium salt) | ||
Cyclic di-IMP (sodium salt) (c-di-IMP) is a synthetic second messenger structurally related to the bacterial second messengers cyclic di-GMP and cyclic di-AMP . C-di-IMP has adjuvant properties when co-administered with ... |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T0948L | Corticosterone | 17-Deoxycortisol,11β,21-Dihydroxyprogesterone,Kendall's compound B,Corticosterone (From plants) | Glucocorticoid Receptor , Endogenous Metabolite |
Corticosterone (Kendall's compound B) is an adrenocortical steroid with salocorticoid and glucocorticoid activity that is orally active. Corticosterone is involved in the regulation of energy, immune responses, and stres... | |||
TN1998 | Notoginsenoside T5 | MMP | |
Total panax notoginsenosides (TPNS) are the main active ingredients in San-Chi, the root of(Burk) F.H. Chen, which belongs to the Araliaceae family and has been used in traditional Chinese medicine to treat atheroscleros... |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-03203 | CD40 Protein, Rat, Recombinant (His) | Rat | HEK293 Cells |
CD40 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 20.6 kDa and the accession number is A0A8I6A2T5. | |||
TMPY-01181 | CD40 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
CD40 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 20.7 kDa and the accession number is A0A0S2Z3C7. | |||
TMPY-05957 | CD40 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
CD40 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 20.81 kDa and the accession number is P27512-1. | |||
TMPY-02022 | CD40 Ligand Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
CD40 Ligand Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 42.8 kDa and the accession number is P29965. | |||
TMPY-04086 | CD40 Ligand Protein, Canine, Recombinant | Canine | HEK293 Cells |
CD40 Ligand Protein, Canine, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 16 kDa and the accession number is O97626. | |||
TMPY-03301 | CD40 Ligand Protein, Rat, Recombinant (hFc) | Rat | HEK293 Cells |
CD40 Ligand Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 44.4 kDa and the accession number is Q9Z2V2. | |||
TMPY-04065 | CD40 Ligand Protein, Canine, Recombinant (mFc) | Canine | HEK293 Cells |
CD40 Ligand Protein, Canine, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 42.5 kDa and the accession number is O97626. | |||
TMPY-03542 | CD40 Ligand Protein, Rhesus, Recombinant (hFc) | Rhesus | HEK293 Cells |
CD40 Ligand Protein, Rhesus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 44.7 kDa and the accession number is A0A8J8XRR8. | |||
TMPY-03211 | CD40 Protein, Rhesus, Recombinant (hFc) | Rhesus | HEK293 Cells |
CD40 Protein, Rhesus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 46.2 kDa and the accession number is F6SNI1. | |||
TMPY-03083 | CD40 Protein, Rat, Recombinant (hFc) | Rat | HEK293 Cells |
CD40 Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 46.2 kDa and the accession number is Q4QQW2. | |||
TMPY-03944 | CD40 Protein, Canine, Recombinant | Canine | HEK293 Cells |
CD40 Protein, Canine, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 19.9 kDa and the accession number is Q7YRL5. | |||
TMPH-03201 | CD40 Ligand Protein, Rabbit, Recombinant (His) | Rabbit | P. pastoris (Yeast) |
N/A. CD40 Ligand Protein, Rabbit, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 18.2 kDa and the accession number is G1SKP7. | |||
TMPY-04089 | CD40 Protein, Canine, Recombinant (His) | Canine | HEK293 Cells |
CD40 Protein, Canine, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 20.5 kDa and the accession number is Q7YRL5. | |||
TMPY-03212 | CD40 Protein, Rhesus, Recombinant (His) | Rhesus | HEK293 Cells |
CD40 Protein, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 20.7 kDa and the accession number is F6SNI1. | |||
TMPY-03907 | CD40 Protein, Canine, Recombinant (hFc) | Canine | HEK293 Cells |
CD40 Protein, Canine, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 46.1 kDa and the accession number is Q7YRL5. | |||
TMPH-03200 | CD40 Ligand Protein, Rabbit, Recombinant (E. coli, His) | Rabbit | E. coli |
N/A. CD40 Ligand Protein, Rabbit, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 20.2 kDa and the accession number is G1SKP7. | |||
TMPY-02793 | CD40 Ligand Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells |
CD40 Ligand Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 44.4 kDa and the accession number is P27548. | |||
TMPK-00170 | CD40 Protein, Human, Recombinant (aa 21-193, His & Avi), Biotinylated | Human | HEK293 Cells |
CD40 is a costimulatory protein found on antigen presenting cells and is required for their activation. The binding of CD154 (CD40L) on TH cells to CD40 activates antigen presenting cells and induces a variety of downstr... | |||
TMPJ-00634 | CD40 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells |
CD40 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 28-30 KDa and the accession number is G7PG38. | |||
TMPJ-01420 | CD40 Protein, Cynomolgus, Recombinant (hFc) | Cynomolgus | HEK293 Cells |
CD40 Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 48-70 KDa and the accession number is XP_005569275.1. | |||
TMPY-05359 | CD40 Protein, Human, Recombinant (mFc) | Human | HEK293 Cells |
CD40 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 45.5 kDa and the accession number is NP_001309350.1. | |||
TMPY-00482 | CD40 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
CD40 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 46.2 kDa and the accession number is A0A0S2Z3C7. | |||
TMPY-06687 | CD40 Ligand Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
CD40 Ligand Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 17.37 kDa and the accession number is P27548. | |||
TMPJ-00151 | CD40 Ligand Protein, Human, Recombinant | Human | E. coli |
CD40 Ligand Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 15 KDa and the accession number is P29965. | |||
TMPY-05614 | CD40 Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 Cells |
CD40 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 22.4 kDa and the accession number is A0A0S2Z3C7. | |||
TMPY-01758 | CD40 Ligand Protein, Human, Recombinant (His) | Human | E. coli |
CD40 Ligand Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 17.7 kDa and the accession number is P29965. | |||
TMPJ-00153 | CD40 Ligand Protein, Human, Recombinant (His & Flag) | Human | HEK293 Cells |
CD40 Ligand Protein, Human, Recombinant (His & Flag) is expressed in HEK293 mammalian cells with N-6xHis-Flag tag. The predicted molecular weight is 19-24 KDa and the accession number is P29965. | |||
TMPY-05425 | CD40 Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells |
CD40 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 46.4 kDa and the accession number is P27512-1. | |||
TMPJ-00152 | CD40 Ligand Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 Cells |
CD40 Ligand Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with N-6xHis-Avi tag. The predicted molecular weight is 23-28 KDa and the accession number is P29965. | |||
TMPY-05599 | CD40 Protein, Human, Recombinant (hFc & Avi), Biotinylated | Human | HEK293 Cells |
CD40 Protein, Human, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with hFc and Avi tag. The predicted molecular weight is 47.7 kDa and the accession number is A0A0S2Z3C7. | |||
TMPJ-00150 | CD40 Ligand Protein, Human, Recombinant (Mammalian) | Human | HEK293 Cells |
CD40 Ligand Protein, Human, Recombinant (Mammalian) is expressed in HEK293 mammalian cells. The predicted molecular weight is 16-18 KDa and the accession number is P29965. | |||
TMPY-04994 | CD40 Protein, Mouse, Recombinant (rFc) | Mouse | HEK293 Cells |
CD40 Protein, Mouse, Recombinant (rFc) is expressed in HEK293 mammalian cells with rFc tag. The predicted molecular weight is 45.4 kDa and the accession number is P27512-1. | |||
TMPY-05646 | CD40 Ligand Protein, Human, Recombinant (hFc & Avi), Biotinylated | Human | HEK293 Cells |
CD40 Ligand Protein, Human, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with hFc and Avi tag. The predicted molecular weight is 44.7 kDa and the accession number is P29965. | |||
TMPK-00860 | CD40 Ligand Protein, Mouse, Recombinant (monomeric hFc) | Mouse | HEK293 Cells |
CD40 ligand or CD40L, also called CD154, is a protein that is primarily expressed on activated T cells and is a member of the TNF superfamily of molecules. It binds to CD40 (protein) on antigen-presenting cells (APC), w... | |||
TMPK-01398 | CD40 Ligand Trimer Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
CD40 ligand or CD40L, also called CD154, is a protein that is primarily expressed on activated T cells and is a member of the TNF superfamily of molecules. It binds to CD40 (protein) on antigen-presenting cells (APC), w... | |||
TMPY-06024 | CD40 Protein, Mouse, Recombinant (His & Avi), Biotinylated | Mouse | HEK293 Cells |
CD40 Protein, Mouse, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 22.5 kDa and the accession number is P27512-1. | |||
TMPJ-00920 | CD40 Ligand Protein, Mouse, Recombinant (aa 112-260, His) | Mouse | HEK293 Cells |
CD40 Ligand, also known as TNFSF5, CD154, is a type II transmembrane glycoprotein member of the TNF superfamily. Mature mouse CD40 Ligand consists of a 22 amino acid (aa) cytoplasmic domain, a transmembrane segment, and ... | |||
TMPK-00154 | CD40 Ligand Protein (Primary Amine Labeling), Human, Recombinant (His & Flag), Biotinylated | Human | HEK293 Cells |
CD40 ligand or CD40L, also called CD154, is a protein that is primarily expressed on activated T cells and is a member of the TNF superfamily of molecules. It binds to CD40 (protein) on antigen-presenting cells (APC), w... | |||
TMPH-02439 | CD40L Protein, Rhesus macaque, Recombinant (His) | Rhesus | E. coli |
CD40L Protein, Rhesus macaque, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 28.5 kDa and the accession number is P63304. | |||
TMPH-01514 | IGIP Protein, Human, Recombinant (His & TF) | Human | Baculovirus Insect Cells |
Enhances IgA secretion from B-cells stimulated via CD40. | |||
TMPH-01513 | IGIP Protein, Human, Recombinant (His & KSI) | Human | E. coli |
Enhances IgA secretion from B-cells stimulated via CD40. | |||
TMPH-00540 | Epstein-Barr virus (strain GD1) LMP1 Protein (His) | EBV | P. pastoris (Yeast) |
Acts as a CD40 functional homolog to prevent apoptosis of infected B-lymphocytes and drive their proliferation. Functions as a constitutively active tumor necrosis factor receptor that induces the activation of several s... | |||
TMPH-00542 | Epstein-Barr virus (strain Raji) LMP1 Protein (His) | EBV | P. pastoris (Yeast) |
Acts as a CD40 functional homolog to prevent apoptosis of infected B-lymphocytes and drive their proliferation. Functions as a constitutively active tumor necrosis factor receptor that induces the activation of several s... | |||
TMPH-00541 | Epstein-Barr virus (strain AG876) LMP1 Protein (His & Myc) | EBV | E. coli |
Acts as a CD40 functional homolog to prevent apoptosis of infected B-lymphocytes and drive their proliferation. Functions as a constitutively active tumor necrosis factor receptor that induces the activation of several s... | |||
TMPY-02404 | ADAM9 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
ADAM9 (A disintegrin and metallopeptidase domain 9, MDC9, meltrin gamma), is a type 1 transmembrane protein that has been associated with cancer development and metastases. ADAM9 is consistently overexpressed in various ... | |||
TMPJ-00226 | SLAMF1 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
Signaling lymphocyte activation molecule (SLAM), is a self-ligand glycoprotein which exists not only found on the surface of activated and memory T cells, but also on the surface of activated B cells, dendritic cells, an... | |||
TMPH-02841 | Prohibitin Protein, Mouse, Recombinant (His) | Mouse | E. coli |
Protein with pleiotropic attributes mediated in a cell-compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regul... |