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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T78763 | ABCB1-IN-1 | ||
ABCB1-IN-1 (compound 3) is a potent inhibitor of ABCB1 that promotes cell apoptosis. Featuring 1-benzylimidazole, it exhibits IC50 values of 1.26 μM for Colo205 cells and 2.21 μM for Colo320 cells, respectively [1]. | |||
TN1651 | Furanodiene | Apoptosis , PARP , Reactive Oxygen Species , Caspase , CDK , P-gp | |
Furanodiene has anti-inflammatory and antioxidant activities, it is active against gram-positive bacteria and Candida albicans. | |||
T3S0012 | Coniferyl ferulate | P-gp , GST | |
Coniferyl ferulate is a strong inhibitor of glutathione S-transferase (GST) isolated from Radix Angelicae sinensis. It shows strong inhibition of human placental GST (IC50: 0.3 μM). It also reverses multidrug resistance ... | |||
T2S0223 | Isosinensetin | 6-Demethoxynobiletin | Antioxidant , HIV Protease , Antibacterial , P-gp |
1. Isosinensetin (6-Demethoxynobiletin) shows antioxidant and HIV-1 protease inhibiting activities. | |||
T8426 | Encequidar | HM30181,HM30181A | P-gp |
Encequidar (HM30181A) is a potent and selective P-glycoprotein inhibitor. | |||
TN4761 | Phellamurin | P-gp | |
Phellamurin inhibits intestinal P-glycoprotein in a dose-dependent manner, there is a serious interaction occurred between Phellamurin with cyclosporin, to ensure the efficacy of cyclosporin, we suggest that the coadmini... | |||
T12341 | P-gp inhibitor 1 | Others , P-gp | |
P-gp inhibitor 1 inhibits reversing P-glycoprotein-mediated multidrug resistance with an EC50 of 57.9 nM (K562/A02 cells). | |||
T2S0271 | Voacamine | Voacanginine | Cannabinoid Receptor , P-gp |
Voacamine (Voacanginine) is an indole alkaloid. Voacamine exhibits potent cannabinoid CB1 receptor antagonistic activity. Voacamine also inhibits P-glycoprotein (P-gp) action in multidrug-resistant tumor cells.Voacangini... | |||
TJS1159 | Chrysosplenetin | Chrysosptertin B | P450 , Ferroptosis , P-gp |
Chrysosplenetin is a metabolic inhibitor of artemisinin. | |||
T11071 | Dofequidar fumarate | MS-209 | P-gp |
Dofequidar fumarate (MS-209)(MS-209 fumarate), a quinoline-based compound administered orally, is known for counteracting multidrug resistance (MDR) through the inhibition of ABCB1/P-glycoprotein (P-gp) and ABCC1/MDR-ass... | |||
T16561 | Polyoxyethylene stearate | POES | Antibacterial , P-gp |
Polyoxyethylene stearate (POES) is an agent of non-ionic emulsifying. | |||
T3002 | Piperine | 1-Piperoylpiperidine,Bioperine | P450 , Endogenous Metabolite , P-gp , Autophagy |
Piperine (Bioperine) , a alkaloid, has been used in trials studying the treatment of multiple myeloma and deglutition disorders. | |||
T6287 | Tariquidar | XR9576 | P-gp |
Tariquidar (XR9576)(Kd=5.1 nM) is a specific and effective non-competitive inhibitor of P-glycoprotein. It can reverse drug resistance in MDR cell Lines. | |||
T2S1200 | Sinapine | Antioxidant , P-gp , AChE | |
1. Sinapine, an alkaloid from seeds of the cruciferous species, can be used as an effective natural compound for chemo-resistance. 2. Sinapine has antioxidant and radio-protective activities. | |||
T4059 | Selamectin | UK-124114 | Chloride channel , P-gp , Parasite |
Selamectin (UK-124114) is a macrocyclic lactone derivative of ivermectin, an anthelmintic that potentiates glutamate- and GABA-gated chloride channel opening in nematodes. In an H. contortus larval development assay, sel... | |||
T4034 | Solamargine | Solamargin,δ-Solanigrine | Apoptosis , p38 MAPK , P-gp , STAT |
Solamargine (δ-Solanigrine) is a major steroidal alkaloid glycoside extracted from a traditional Chinese medicine herb, Solanum nigrum L. (SNL); has been shown to inhibit growth and induce apoptosis of various cancer cel... | |||
T13383 | Zamicastat | BIA 5-1058 | BCRP , Hydroxylase , P-gp |
Zamicastat (BIA 5-1058) is an inhibitor of dopamine β-hydroxylase (DBH), and is also a concentration-dependent dual inhibitor of P-gp and BCRP(IC50 values of 73.8 μM and 17.0 μM, respectively). | |||
T3392 | Sinapine thiocyanate | P-gp , AChE | |
Sinapine Thiocyanate, is a derivative of Sinapine (S486605), an alkaloidal amine found in black mustard seeds. It is the choline ester of Sinapic Acid (S486800). It is also a phenolic-chloine conjugates, acting as anti-o... | |||
T8389 | Trifluoperazine | trifluoroperazine | CaMK , Dopamine Receptor , Influenza Virus , Adrenergic Receptor , P-gp , Autophagy |
Trifluoperazine (trifluoroperazine) is a Dopamine D2 receptor inhibitor(IC50 : 1.2 nM), and Treatment of schizophrenia. | |||
T11578L | Encequidar mesylate | HM30181 mesylate,HM30181A mesylate | P-gp |
Encequidar mesylate (HM30181A mesylate) is a competitive P-glycoprotein inhibitor. |