synaptic — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T9063	Clathrin-IN-1		HIV Protease
	Clathrin-IN-1 is a inhibitor of clathrin, and inhibits clathrin-mediated endocytosis (CME) by associating with the terminal domain of clathrin. It has the potential for anti-cancer research.		HIV Protease
T22012	7BIO		FLT , DYRK , Aurora Kinase
	7-bromoindirubin-3'-oxime (7BIO) is a caspase independent nonapoptotic cell death inducer. 7BIO is an inhibitor of FLT3, DYRK1A, DYRK2, Aurora B and Aurora C kinases.		FLT , DYRK , Aurora Kinase
T1092	Zolmitriptan	311C90,BW-311C90	5-HT Receptor
	Zolmitriptan (311C90) selectively binds to and activates serotonin (5-HT) 1B receptors expressed in intracranial arteries and 5-HT 1D receptors located on peripheral trigeminal sensory nerve terminals in the meninges and...		5-HT Receptor
T0192	Levetiracetam	UCB L059,SIB-S1	DNA Methyltransferase , Others , Calcium Channel
	Levetiracetam (SIB-S1) is a relatively unique anticonvulsant that is typically used in combination with other antiepileptic medications for partial onset seizures. Levetiracetam has been linked to rare instances of serum...		DNA Methyltransferase , Others , Calcium Channel
TP1559L	Ziconotide Acetate (107452-89-1 free base)	Prialt,Ziconotide Acetate	Calcium Channel
	Ziconotide Acetate (107452-89-1 free base) (Prialt) is an analgesic agent and has been used to treat neuropathic and non-neuropathic pain. Ziconotide Acetate (107452-89-1 free base) acts by binding to N-type calcium chan...		Calcium Channel
T1279	Vilazodone	SB659746A,EMD 68843	5-HT Receptor , Serotonin Transporter
	Vilazodone (SB659746A) is a selective serotonin (5-HT) reuptake inhibitor (SSRI) and a 5-HT-1A receptor partial agonist, with antidepressant and anti-anxiety activities. Vilazodone inhibits the reuptake of serotonin from...		5-HT Receptor , Serotonin Transporter
T10893	CS-722 Free base		Others
	CS-722 Free base is a synthetic central muscle relaxant with muscle relaxant activity and inhibitory effect on spinal reflex. CS-722 Free base may inhibit spontaneous inhibitory post-synaptic current and excitatory post-...		Others
TP1868	Proctolin		Others
	Proctolin is a bioactive neuropeptide that modulates interneuronal and neuromuscular synaptic transmission in a wide variety of arthropods.		Others
T7516	ZD7288	ICI D7288	HCN Channel
	ZD7288 (ICI D7288), a selective hyperpolarization-activated cyclic nucleotide-gated channel blocker, inhibits hippocampal synaptic plasticity.		HCN Channel
T30549	BMY-21502	Bms-181168,Bms 181168,Bmy 21502,Bmy21502,Bms181168	Antioxidant
	BMY-21502 is a potential cognitive enhancer that shows anti-hypoxia effects in the KCN-hypoxia model, delays the decay of hippocampal synaptic enhancement in vitro, and can be used to study Alzheimer's disease.		Antioxidant
T11684	Isoguvacine hydrochloride	1,2,3,6-tetrahydro-4-pyridinecarboxylic acid hydrochloride	GABA Receptor
	Isoguvacine hydrochloride (1,2,3,6-tetrahydro-4-pyridinecarboxylic acid hydrochloride) is a GABA receptor agonist. Isoguvacine hydrochloride binds to rat synaptic cortical membranes and activates α1β2γ2S, α2β2γ2S, α3β2γ2...		GABA Receptor
T19812	Propentofylline	HWA-285,Karsivan,Propentophylline,Hextol,HWA 285,HWA285	PDE
	Propentofylline (Hextol) is a methylxanthine derivative with neuroprotective, antiproliferative, and anti-inflammatory activity and enhanced synaptic adenosine signaling, which may be useful in the study of Alzheimer's d...		PDE
T0869	Atomoxetine hydrochloride	Tomoxetine hydrochloride,(R)-Tomoxetine hydrochloride,LY 139603,Atomoxetine HCl,LY 139603 HCl	Dopamine Receptor , 5-HT Receptor , Norepinephrine
	Atomoxetine hydrochloride (LY 139603) is the hydrochloride salt of atomoxetine, a phenoxy-3-propylamine derivative and selective non-stimulant, norepinephrine reuptake inhibitor with cognitive-enhancing activity. Althou...		Dopamine Receptor , 5-HT Receptor , Norepinephrine
T9299	D-Leucine	(R)-Leucine	Endogenous Metabolite
	D-Leucine ((R)-Leucine) potently terminates seizures even after the onset of seizure activity. D-leucine reduces long-term potentiation but had no effect on basal synaptic transmission in vitro.		Endogenous Metabolite
T5512	JNJ16259685	.TN.T 16259685	GluR
	JNJ16259685 (TN.T 16259685) is a selective mGluR1 antagonist, and inhibits the synaptic activation of mGluR1 in a concentration-dependent manner with IC50 of 19 nM.		GluR
T21153	Clothianidin	TI435,TI-435,TI 435,Celero	AChR
	Clothianidin (TI 435), an insecticide, acts as an agonist of acetylcholine to stimulate nAChR, thereby activating post-synaptic acetylcholine receptors but not inhibiting AChE.		AChR
T26357	Pitstop 2		Apoptosis
	Pitstop2 is a selective inhibitor of amphiphysin association of clathrin terminal domain with an IC50 value of 12 μM. Pitstop2 acutely interferes with receptor-mediated endocytosis, entry of HIV, and synaptic vesicle rec...		Apoptosis
T1566	Aripiprazole	OPC-14597	5-HT Receptor
	Aripiprazole (OPC-14597) is an antipsychotic agent that is structurally related to piperazines and quinolones. It is a partial agonist of SEROTONIN RECEPTOR, 5-HT1A and DOPAMINE D2 RECEPTORS, where it also functions as a...		5-HT Receptor
T0958	Penicillin G sodium salt	Penicillin G Sodium,Benzylpenicillin sodium salt,Benzylpenicillin Sodium	GABA Receptor , Antibacterial , Antibiotic
	Penicillin G sodium(Benzylpenicillin sodium) salt is a penicillin derivative commonly used in the form of its sodium or potassium salts in the treatment of a variety of infections. It is effective against most gram-posit...		GABA Receptor , Antibacterial , Antibiotic
TN1202	(-)-α-Pinene	(1S)-(-)-Alpha-Pinene	Virus Protease , GABA Receptor , Endogenous Metabolite , Antibacterial
	(-)-α-Pinene ((1S)-(-)-Alpha-Pinene) enhances the quantity of NREMS without affecting the intensity of NREMS by prolonging GABAergic synaptic transmission, acting as a partial modulator of GABAA-BZD receptors and directl...