Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Isoguvacine hydrochloride (1,2,3,6-tetrahydro-4-pyridinecarboxylic acid hydrochloride) is a GABA receptor agonist. Isoguvacine hydrochloride binds to rat synaptic cortical membranes and activates α1β2γ2S, α2β2γ2S, α3β2γ2S, α5β2γ2S, and ρ1 subunit GABAA receptors.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
10 mg | In stock | $ 30.00 | |
25 mg | In stock | $ 57.00 | |
50 mg | In stock | $ 96.00 | |
100 mg | In stock | $ 147.00 | |
500 mg | In stock | $ 369.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 29.00 |
Description | Isoguvacine hydrochloride (1,2,3,6-tetrahydro-4-pyridinecarboxylic acid hydrochloride) is a GABA receptor agonist. Isoguvacine hydrochloride binds to rat synaptic cortical membranes and activates α1β2γ2S, α2β2γ2S, α3β2γ2S, α5β2γ2S, and ρ1 subunit GABAA receptors. |
In vitro | Treatment of 50 μM Isoguvacine to block epileptiform events in 2 of 6 organotypic hippocampal slice cultures, Isoguvacine dose-dependently inhibits hypomagnesium-induced epileptiform events[2]. Isoguvacine binds to mouse forebrain synaptic membrane preparations and can specifically bind to GABA, muscimol and bicuculline, but not picrotoxin or diaminobutyric acid. The highest levels of binding are observed in the cerebellum, cortex and hippocampus[3]. |
Synonyms | 1,2,3,6-tetrahydro-4-pyridinecarboxylic acid hydrochloride |
Molecular Weight | 163.6 |
Formula | C6H10ClNO2 |
CAS No. | 68547-97-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 90 mg/mL (550.12 mM)
DMSO: 20 mg/mL (122.25 mM), sonification is recommended.
You can also refer to dose conversion for different animals. More
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Isoguvacine hydrochloride 68547-97-7 Membrane transporter/Ion channel Neuroscience GABA Receptor γ-Aminobutyric acid Receptor Isoguvacine 1,2,3,6-tetrahydro-4-pyridinecarboxylic acid hydrochloride Gamma-aminobutyric acid Receptor Isoguvacine Hydrochloride inhibit Inhibitor inhibitor