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Atomoxetine hydrochloride

Catalog No. T0869 CAS 82248-59-7

Synonyms: Tomoxetine hydrochloride, (R)-Tomoxetine hydrochloride, LY 139603, Atomoxetine HCl, LY 139603 HCl

Atomoxetine hydrochloride (LY 139603) is the hydrochloride salt of atomoxetine, a phenoxy-3-propylamine derivative and selective non-stimulant, norepinephrine reuptake inhibitor with cognitive-enhancing activity. Although its precise mechanism of action is unknown, atomoxetine appears to selectively inhibit the pre-synaptic norepinephrine transporter, resulting in inhibition of the presynaptic reabsorption of norepinephrine and prolongation of norepinephrine activity in the synaptic cleft. The effect on cognitive brain function may result in improved attention and decreased impulsivity and activity levels.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Atomoxetine hydrochloride Chemical Structure

Atomoxetine hydrochloride, CAS 82248-59-7

Pack Size	Availability	Price/USD
25 mg	In stock	$ 40.00
50 mg	In stock	$ 54.00
100 mg	In stock	$ 77.00
200 mg	In stock	$ 117.00

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Purity: 99.8%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Targets&IC50

NET:5 nM(Ki), 5-HT:77 nM(Ki), Dopamine transporter:1451 nM(Ki)

Synonyms	Tomoxetine hydrochloride, (R)-Tomoxetine hydrochloride, LY 139603, Atomoxetine HCl, LY 139603 HCl
Molecular Weight	291.82
Formula	C17H22ClNO
CAS No.	82248-59-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 198.8 mM

H2O: 6.9 mM

References and Literature

1. Bymaster FP, et al. Neuropsychopharmacology, 2002, 27(5), 699-711. 2. Zerbe RL, et al. J Pharmacol Exp Ther, 1985, 232(1), 139-143. 3. Wong DT, et al. J Pharmacol Exp Ther, 1982, 222(1), 61-65.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Neurodegenerative Disease Compound Library Anti-Cancer Clinical Compound Library Drug Repurposing Compound Library Anti-Cancer Approved Drug Library GPCR Compound Library Inhibitor Library Anti-Cancer Drug Library Neuronal Signaling Compound Library CNS-Penetrant Compound Library Anti-Cardiovascular Disease Compound Library

Related Products

Related compounds with same targets

MPTP hydrochloride PD-168077 maleate Penfluridol Quinpirole Hydrochloride CY 208-243 Amisulpride Methiothepin mesylate Propionylpromazine hydrochloride

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Atomoxetine hydrochloride 82248-59-7 GPCR/G Protein Neuroscience Dopamine Receptor 5-HT Receptor Norepinephrine LY139603 Tomoxetine hydrochloride LY-139603 Atomoxetine Hydrochloride (R)-Tomoxetine hydrochloride Adrenergic Receptor Tomoxetine inhibit Tomoxetine Hydrochloride Atomoxetine LY 139603 Beta Receptor Inhibitor Atomoxetine HCl (R)-Tomoxetine LY 139603 HCl inhibitor

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