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Propentofylline

Catalog No. T19812 CAS 55242-55-2

Synonyms: HWA-285, Karsivan, Propentophylline, Hextol, HWA 285, HWA285

Propentofylline (Hextol) is a methylxanthine derivative with neuroprotective, antiproliferative, and anti-inflammatory activity and enhanced synaptic adenosine signaling, which may be useful in the study of Alzheimer's disease, vascular dementia, cognitive impairment, dementia, and chronic pain.

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Propentofylline, CAS 55242-55-2

Pack Size	Availability	Price/USD
1 mg	In stock	$ 63.00
5 mg	In stock	$ 148.00
10 mg	In stock	$ 223.00
25 mg	In stock	$ 376.00
50 mg	In stock	$ 555.00
100 mg	In stock	$ 789.00
1 mL * 10 mM (in DMSO)	In stock	$ 159.00

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Purity: 99.42%

Purity: 99.11%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	HWA-285, Karsivan, Propentophylline, Hextol, HWA 285, HWA285
Molecular Weight	306.36
Formula	C15H22N4O3
CAS No.	55242-55-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 5 mg/mL (16.32 mM), Sonication is recommended.

References and Literature

1. Hudlicka O,et al. The effect of a xanthine derivative, 1-(5' oxohexyl)-3-methyl-7-propylxanthine (HWA 285), on heart performance and regional blood flow in dogs and rabbits. Br J Pharmacol. 1981;72(4):723-730. 2. Sweitzer S, et al. Propentofylline: glial modulation, neuroprotection, and alleviation of chronic pain. Handb Exp Pharmacol. 2011;(200):235-250. 3. Landry RP,et al. Propentofylline, a CNS glial modulator does not decrease pain in post-herpetic neuralgia patients: in vitro evidence for differential responses in human and rodent microglia and macrophages. Exp Neurol. 2012 Apr;234(2):340-50. 4. Parkinson FE, et al. Propentofylline: a nucleoside transport inhibitor with neuroprotective effects in cerebral ischemia. Gen Pharmacol. 1994 Oct;25(6):1053-8.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Propentofylline 55242-55-2 Metabolism PDE HWA-285 Karsivan Propentophylline Hextol HWA 285 HWA285 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.