rodent — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T9532	MRT-81		Others
	MRT-81 inhibits human and rodent smoothened Smo receptors effectively with an IC50 value of 41 nM in the Shh-light2 cells. MRT-81 has potent hedgehog inhibiting activity. MRT-81 also can be used for the research of cance...		Others
T9786	Lu AF27139		P2X Receptor
	Lu AF27139 is an effective and selective antagonist of P2X7 receptor (IC50s of 12 and 2.4 nM for human and rat, Kis of 22, 54, and 13 nM for mouse, human, and rat, respectively). Lu AF27139 can be used in CNS diseases st...		P2X Receptor
T7512	BMS-191011	BMS-A	Potassium Channel
	BMS-191011 (BMS-A) is an activator of large-conductance calcium-activated potassium (BKCa) channels ,effective in stroke models		Potassium Channel
T21818	Pregnenolone Carbonitrile	Pregnenolone 16α-carbonitrile ,5-Pregnen-3β-ol-20-one-16α-carbonitrile	P450
	Pregnenolone Carbonitrile (5-Pregnen-3β-ol-20-one-16α-carbonitrile) is an activator of rodent-PXR and induces the expression of CYP3A.		P450
TP1666L	Kisspeptin-10, rat acetate(478507-53-8 free base)		GPR , Kisspeptin
	Kisspeptin-10, rat acetate is an endogenous ligand for the rodent kisspeptin receptor (KISS1, GPR54).		GPR , Kisspeptin
T2925	Schisandrin B	gamma-Schisandrin,Schizandrin B,Schisandrin B (Sch B),Wuweizisu-B	ATM/ATR , Reactive Oxygen Species , Autophagy
	Schisandrin B (Schisandrin B (Sch B)) has an antioxidant effect on rodent liver and heart.		ATM/ATR , Reactive Oxygen Species , Autophagy
T0489	Flutamide	SCH 13521	Androgen Receptor
	Flutamide (SCH 13521) is an antiandrogen with about the same potency as cyproterone in rodent and canine species.		Androgen Receptor
T1860	Imepitoin	AWD 131-138,ELB-138	GABA Receptor
	Imepitoin (AWD 131-138) is a new low-affinity partial benzodiazepine receptor agonist. It shows potent anticonvulsant and anxiolytic properties in rodent models.		GABA Receptor
T25824	ML400	ML 400,CID-73050863,ML-400,CID73050863,CID 73050863	Phosphatase
	ML400 (CID73050863) is an allosteric inhibitor of LMPTP with an EC50 of 1μM. ML400 displays good cell-based activity and rodent pharmacokinetics.		Phosphatase
T22419	S-Methylisothiourea sulfate	(S)-Methylisothiourea sulfate	NOS , NO Synthase , HSV
	S-Methylisothiourea sulfate ((S)-Methylisothiourea sulfate) is a potent and selective inhibitor of iNOS and exerts beneficial effects in rodent models of septic shock[1].		NOS , NO Synthase , HSV
T39762	AHR antagonist 5 free base		Aryl Hydrocarbon Receptor
	AHR antagonist 5 free base is an orally active antagonist of AHR with IC50s of ~35-150 nM in human and rodent cell lines.		Aryl Hydrocarbon Receptor
T8960	MONNA		Chloride channel
	MONNA is a potent TMEM16A (Anoctamin-1) blocker (IC50 : 80 nM). It induces vasorelaxation of rodent resistance arteries in presence or absence of chloride ions.		Chloride channel
T24051	Exisulind	Sulindac sulfone,CP248	Apoptosis , PKA
	Exisulind (CP248) induces apoptosis through the activation of protein kinase G (PKG). Exisulind exhibits antineoplastic activity in solid tumour and haematological cancer cell lines and is an inhibitor of tumour growth i...		Apoptosis , PKA
T36851L	Peptide5 acetate		Others
	Peptide5 acetate reduces animal swelling, astrogliosis, and neuronal cell death after spinal cord injury. Peptide5 acetate significantly reduces the degree of spinal cord injury (SCI) in a rodent ex vivo model.		Others
T16977	Talampanel	GYKI-53773,LY-300164	Apoptosis , GluR
	Talampanel (LY-300164) is an orally and selective α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor antagonist with anti-seizure activity. Talampanel (IVAX) has neuroprotective effects in rodent stroke models.		Apoptosis , GluR
T70084	Dersalazine	Dersalazine Free Base	IL Receptor , Platelet aggregation
	Dersalazine (Dersalazine Free Base), an inhibitor of platelet-activating factor, exerts intestinal anti-inflammatory activity in different rodent types of colitis by down-regulating IL-17 expression, with potential effic...		IL Receptor , Platelet aggregation
T15260	Evenamide	NW-3509	Sodium Channel
	Evenamide (NW-3509) is a sodium channel blocker. Which shows efficacy in a broad spectrum of rodent models of psychosis, mania, depression, and aggressiveness.		Sodium Channel
T40588	Acifluorfen		Others
	Acifluorfen, a protoporphyrinogen oxidase (PROTOX) inhibitor herbicide, promotes the accumulation of protoporphyrin IX (PPIX) and induces tumors in rodent livers. It causes significant photooxidative damage to pigments a...		Others
T4364	Aftin-4	Aftin 4,Aftin4	Beta Amyloid , Gamma-secretase
	Aftin-4, an amyloid forty-two inducer, activates γ-secretase, promoting the generation of amyloid-β-1-42 (Aβ1-42) from amyloid-β protein precursor. Aftin-4(Aftin4) increased Aβ-1-42, but not Aβ-1-40 in mouse hipppocampus...		Beta Amyloid , Gamma-secretase
T5S0661	Koumine		Others
	1. Koumine can treat the diabetic neuropathy. 2. Koumine has antineoplastic effect, may be a future breast cancer chemotherapeutic agent. 3. Koumine has a significant analgesic effect in rodent behavioral models of infla...		Others