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Flutamide

Catalog No. T0489   CAS 13311-84-7
Synonyms: SCH 13521

Flutamide (SCH 13521) is an antiandrogen with about the same potency as cyproterone in rodent and canine species.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
Flutamide Chemical Structure
Flutamide, CAS 13311-84-7
Pack Size Availability Price/USD Quantity
200 mg In stock $ 30.00
500 mg In stock $ 46.00
1 g In stock $ 48.00
5 g Inquiry $ 92.00
1 mL * 10 mM (in DMSO) In stock $ 51.00
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Purity: 99.92%
Purity: 99.6%
Purity: 99.41%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Flutamide (SCH 13521) is an antiandrogen with about the same potency as cyproterone in rodent and canine species.
Targets&IC50 Androgen Receptor:55 nM(Ki)
Kinase Assay Androgen Receptor Assay: Aliquots of 100 μl cytosol are incubated at 0-4°C for 18 h with 100 μl of the indicated saturating concentration of [3H]T in the presence or absence of increasing concentrations of nonlabeled T, DHT, flutamide (FLU) or flutamide-OH (FLU-OH). At the end of the incubation, free and bound T are separated by the addition of 200 μl dextran-coated charcoal (1 % charcoal, 0.1% dextran T-70, 0.1% gelatin, 1.5 mM EDTA and 50 mM Tris (pH 7.4)) for 15 min before centrifugation at 2300 × g for another 15 min at 0-4°C. Aliquots (350 μl) of the supernatant are transferred to scintillation vials with 10 ml of an aqueous counting solution before counting in a Beckman LS 330 counter.
Cell Research Effect of flutamide on the growth of an androgen-sensitive clone (SEM-l) of mouse mammary carcinoma Shionogi cells in culture. The cells are incubated up to 40 days in medium (MEM + 2% dextran-coated charcoal extracted fetal calf serum) containing the compounds at a concentration of 1 μM. Media are changed every second day.(Only for Reference)
Synonyms SCH 13521
Molecular Weight 276.21
Formula C11H11F3N2O3
CAS No. 13311-84-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 51 mg/mL (184.6 mM)

Ethanol: 51 mg/mL (184.6 mM)

TargetMolReferences and Literature

1. Simard J, et al. Mol Cell Endocrinol, 1986, 44(3), 261-270. 2. Luthy IA, et al. J Steroid Biochem, 1988, 31(5), 845-852. 3. Crawford ED, et al. N Engl J Med, 1989, 321(7), 419-424. 4. Marchetti B, et al. J Steroid Biochem, 1988, 29(6), 691-698.

TargetMolCitations

1. Yang R, Wang X, Wang J, et al. Insights into the sex-dependent reproductive toxicity of 2-ethylhexyl diphenyl phosphate on zebrafish (Danio rerio). Environment International. 2022, 158: 106928.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Drug Library Anti-Cancer Approved Drug Library Anti-Cancer Active Compound Library Anti-Cancer Clinical Compound Library FDA-Approved & Pharmacopeia Drug Library Bioactive Compounds Library Max Fluorochemical Library Approved Drug Library Drug-Fragment Library Pediatric Drug Library

Related Products

Related compounds with same targets
VPC-14228 CSRM617 hydrochloride Luxdegalutamide ARD-2128 Androgen receptor antagonist 9 UT-34 Cyproterone acetate Testosterone propionate

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Keywords

Flutamide 13311-84-7 Endocrinology/Hormones Androgen Receptor Inhibitor SCH-13521 SCH 13521 inhibit SCH13521 inhibitor

 

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