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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
TN1046 | Murrayone | Others | |
Murrayone, a coumarin-containing compound derived from M. paniculata, stands out as the most bioactive substance within this species, primarily due to its unique pharmacological attributes that notably suppress cancer me... | |||
T6347 | Ki16198 | LPA Receptor , LPL Receptor | |
Ki16198 is the methyl ester of Ki16425, which is a LPA antagonist and inhibits LPA1- and LPA3-induced inositol phosphate production with Ki of 0.34 μM and 0.93 μM, respectively, shows weaker inhibition for LPA2, no activ... | |||
T12580 | PTUPB | COX , Epoxide Hydrolase | |
PTUPB is a potent and dual inhibitor of sEH and COX-2 enzymes(IC50 of 0.9 nM and 1.26 μM, respectively). | |||
T22336 | Galloflavin | Dehydrogenase | |
Galloflavin inhibits both the A and B isoforms of lactate dehydrogenase with Ki of 5.46 µM and 15.06 µM, respectively. Galloflavin is also a potential anticancer agent. | |||
T9107 | NP-G2-044 | Others | |
NP-G2-044 is an orally active fascin inhibitor, with an IC50 of ~2 μM. It blocks tumor metastasis and increases antitumor immune response. | |||
T4033 | MSX-130 | MSX 130 | CXCR |
MSX-130 is CXCR4 Antagonist. | |||
T3862 | Irigenin | NF-κB , Integrin | |
Irigenin mediates its antimetastatic effect by specifically and selectively blocking the α9β1 and α4β1 integrin binding sites on the C-C loop of the Extra Domain A domain. It can sensitize TRAIL-induced apoptosis by enha... | |||
T2786 | Oxysophocarpine | Prostaglandin Receptor | |
Oxysophocarpine is extracted from Sophra flavescens Ait. | |||
T10425 | AZ084 | CCR | |
AZ084 is a potent, selective, allosteric, and oral active CCR8 antagonist (Ki: 0.9 nM). It has the potential to treat asthma. | |||
T9963 | MPT0B390 | HDAC | |
MPT0B390 is an inhibitor of HDAC and a TIMP3 inducer inhibiting tumor growth, metastasis, and angiogenesis. | |||
T4032 | MSX-127 | MSX 127 | CXCR |
MSX-127 elicites positive response in peptide CXCR4. | |||
T10297L | AMG 487 | CXCR | |
AMG 487 is a potent and selective antagonist of chemokine (C-X-C motif) receptor 3 (CXCR3) which inhibits the binding of CXCL10 and CXCL11 to CXCR3 with IC50s of 8.0 and 8.2 nM, respectively. | |||
T4306 | CCG-203971 | CCG203971 | Rho , Ras |
CCG-203971 is an inhibitor of SRE activation in the prostate cancer cell line PC-3 (IC50: 6.4 μM), with 87% inhibition of SRE activation achieved at 100 μM. This compound also inhibits PC-3 cell migration (IC50: 4.2 μM),... | |||
T2014 | CCG-1423 | CCG1423 | LRRK2 , Rho , Ras |
CCG-1423, a selective RhoA pathway inhibitor, suppresses SRF-mediated transcription. | |||
T8310 | MMP-9-IN-1 | MMP | |
MMP-9-IN-1 is an inhibitor of specific matrix metalloproteinase-9 (MMP-9). | |||
T3860 | Isoliquiritin apioside | MMP , p38 MAPK , NF-κB | |
Isoliquiritin apioside, isolated from Glycyrrhizae radix rhizome, significantly decreases PMA-induced increases in MMP9 activities and suppresses PMA-induced activation of MAPK and NF-κB. Isoliquiritin apioside auppresse... | |||
T1921 | Alpelisib | BYL-719 | PI3K |
Alpelisib (BYL-719) is a PI3Kα inhibitor (IC50=5 nM) with selective, potent, and oral activity. Alpelisib inhibits PI3Kβ/γ/δ with low activity (IC50=250/290/1200 nM). Alpelisib has antitumor activity and is targeted to P... | |||
T5465 | PF-5274857 | PF-5274857 freebase | Smo |
PF-5274857 (PF-5274857 free base) is an effective and selective hedgehog signaling pathway inhibitor (IC50: 5.8 nM and a Ki: 4.6 nM). PF-5274857 is a potentially attractive clinical candidate for the treatment of tumor t... | |||
T36758 | CAIX Inhibitor S4 | S4 | Carbonic Anhydrase |
CAIX Inhibitor S4 (S4) is an effective inhibitor of carbonic anhydrase IX/XII with a Ki of 7 nM and 2 nM, respectively. The Kis for CA II and CA I are 546 and 5600 nM. | |||
T27730 | KGP94 | KGP-94,KGP 94 | Cysteine Protease |
KGP94 is an inhibitor of cysteine protease Cathepsin L(CTSL). |