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KGP94

Catalog No. T27730   CAS 1131456-28-4
Synonyms: KGP-94, KGP 94

KGP94 is a potent, selective, and competitive inhibitor of the lysosomal endopeptidase enzyme.

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KGP94, CAS 1131456-28-4
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Purity 98%
Biological Description
Chemical Properties
Storage & Solubility Information
Description KGP94 is a potent, selective, and competitive inhibitor of the lysosomal endopeptidase enzyme.
In vitro The novel cathepsin L/K inhibitors KGP94 could inhibit in vitro M2 macrophage invasion and reduce the macrophage-stimulated invasion of 4T1 murine breast cancer cells. KGP94 treatment also reduced the expression of several M2-associated markers, suggesting that cathepsin L activity may be important for IL-4-driven M0 to M2 differentiation[1].
Synonyms KGP-94, KGP 94
Molecular Weight 350.23
Formula C14H12BrN3OS
CAS No. 1131456-28-4

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Parker EN, Odutola SO, Wang Y, Strecker TE, Mukherjee R, Shi Z, Chaplin DJ, Trawick ML, Pinney KG. Synthesis and biological evaluation of a water-soluble phosphate prodrug salt and structural analogues of KGP94, a lead inhibitor of cathepsin L. Bioorg Med Chem Lett. 2017 Mar 1;27(5):1304-1310. doi: 10.1016/j.bmcl.2016.12.039. PubMed PMID: 28117205. 2. Sudhan DR, Rabaglino MB, Wood CE, Siemann DW. Cathepsin L in tumor angiogenesis and its therapeutic intervention by the small molecule inhibitor KGP94. Clin Exp Metastasis. 2016 Jun;33(5):461-73. doi: 10.1007/s10585-016-9790-1. PubMed PMID: 27055649. 3. Sudhan DR, Pampo C, Rice L, Siemann DW. Cathepsin L inactivation leads to multimodal inhibition of prostate cancer cell dissemination in a preclinical bone metastasis model. Int J Cancer. 2016 Jun 1;138(11):2665-77. doi: 10.1002/ijc.29992. PubMed PMID: 26757413; PubMed Central PMCID: PMC4805507. 4. Sudhan DR, Siemann DW. Cathepsin L inhibition by the small molecule KGP94 suppresses tumor microenvironment enhanced metastasis associated cell functions of prostate and breast cancer cells. Clin Exp Metastasis. 2013 Oct;30(7):891-902. doi: 10.1007/s10585-013-9590-9. PubMed PMID: 23748470; PubMed Central PMCID: PMC3823630.

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