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Catalog No. T12580   CAS 1287761-01-6

PTUPB is a potent and dual inhibitor of sEH and COX-2 enzymes(IC50 of 0.9 nM and 1.26 μM, respectively).

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PTUPB, CAS 1287761-01-6
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Purity: 98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description PTUPB is a potent and dual inhibitor of sEH and COX-2 enzymes(IC50 of 0.9 nM and 1.26 μM, respectively).
Targets&IC50 COX-1:1.26 μM, COX-1:100 μM, sEH:0.9 nM
In vitro PTUPB has minimal inhibitory effects on cell proliferation in multiple cancer cell lines, including human melanoma cell and a transformed endothelial cell, whereas it potently inhibits HUVEC proliferation after 3 days of application[1].
In vivo PTUPB inhibits LLC tumor growth by 70-83% and exhibits with no overt toxicity, such as any weight loss when it is compared with the control group. After a period of treatment, the peak plasma concentration of PTUPB is high[1].
Molecular Weight 543.56
Formula C26H24F3N5O3S
CAS No. 1287761-01-6


Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 100 mg/mL (183.97 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Sun CC, et al. PTUPB ameliorates high-fat diet-induced non-alcoholic fatty liver disease via inhibiting NLRP3 inflammasome activation in mice. Biochem Biophys Res Commun. 2020 Mar 19;523(4):1020-1026. 2. Zhang G, et al. Dual inhibition of cyclooxygenase-2 and soluble epoxide hydrolase synergistically suppresses primary tumor growth and metastasis. Proc Natl Acad Sci U S A. 2014 Jul 29;111(30):11127-32. 3. Hwang SH, et al. Synthesis and structure-activity relationship studies of urea-containing pyrazoles as dual inhibitors of cyclooxygenase-2 and soluble epoxide hydrolase.J Med Chem. 2011 Apr 28;54(8):3037-50.

Related compound libraries

This product is contained In the following compound libraries:
Inhibitor Library Immunology/Inflammation Compound Library Neuronal Signaling Compound Library Anti-Aging Compound Library Bioactive Compound Library

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PTUPB 1287761-01-6 代谢 免疫与炎症 神经科学 COX Epoxide Hydrolase Cyclooxygenase inhibit Non-alcoholic obesity Metastasis liver fatty steatosis HUVECs HFD hepatic Inhibitor LLC disease inhibitor