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PTUPB

Name: PTUPB
Brand: TargetMol
SKU: T12580
Price: 74 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T12580Cas No. 1287761-01-6

PTUPB is a potent dual inhibitor of sEH and COX-2 enzymes with IC50 values of 0.9 nM and 1.26 μM, respectively.

PTUPB

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Purity: 98.35%

Catalog No. T12580Cas No. 1287761-01-6

PTUPB is a potent dual inhibitor of sEH and COX-2 enzymes with IC50 values of 0.9 nM and 1.26 μM, respectively.

Pack Size	Price	Availability
1 mg	$74	In Stock
5 mg	$179	In Stock
10 mg	$289	In Stock
25 mg	$538	In Stock
50 mg	$859	In Stock
100 mg	$1,280	In Stock
1 mL x 10 mM (in DMSO)	$216	In Stock

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Batch Information

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Purity:98.35%

Resource Download

COA LCMS HNMR HPLC

Product Introduction

Bioactivity

Description	PTUPB is a potent dual inhibitor of sEH and COX-2 enzymes with IC50 values of 0.9 nM and 1.26 μM, respectively.
Targets&IC50	sEH:0.9 nM, COX-1:1.26 μM, COX-1:100 μM
In vitro	PTUPB has minimal inhibitory effects on cell proliferation in multiple cancer cell lines, including human melanoma cell and a transformed endothelial cell, whereas it potently inhibits HUVEC proliferation after 3 days of application[1].
In vivo	PTUPB inhibits LLC tumor growth by 70-83% and exhibits with no overt toxicity, such as any weight loss when it is compared with the control group. After a period of treatment, the peak plasma concentration of PTUPB is high[1].

Chemical Properties

Molecular Weight	543.56
Formula	C₂₆H₂₄F₃N₅O₃S
Cas No.	1287761-01-6
Smiles	NS(=O)(=O)c1ccc(cc1)-n1nc(CCCNC(=O)Nc2ccc(cc2)C(F)(F)F)cc1-c1ccccc1
Relative Density.	no data available
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (183.97 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8397 mL	9.1986 mL	18.3972 mL	91.9862 mL
5 mM	0.3679 mL	1.8397 mL	3.6794 mL	18.3972 mL
10 mM	0.1840 mL	0.9199 mL	1.8397 mL	9.1986 mL
20 mM	0.0920 mL	0.4599 mL	0.9199 mL	4.5993 mL
50 mM	0.0368 mL	0.1840 mL	0.3679 mL	1.8397 mL
100 mM	0.0184 mL	0.0920 mL	0.1840 mL	0.9199 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc