Powder: -20°C for 3 years
In solvent: -80°C for 2 years
PTUPB is a potent and dual inhibitor of sEH and COX-2 enzymes(IC50 of 0.9 nM and 1.26 μM, respectively).
Description | PTUPB is a potent and dual inhibitor of sEH and COX-2 enzymes(IC50 of 0.9 nM and 1.26 μM, respectively). |
Targets&IC50 | COX-1:1.26 μM, COX-1:100 μM, sEH:0.9 nM |
In vitro | PTUPB has minimal inhibitory effects on cell proliferation in multiple cancer cell lines, including human melanoma cell and a transformed endothelial cell, whereas it potently inhibits HUVEC proliferation after 3 days of application[1]. |
In vivo | PTUPB inhibits LLC tumor growth by 70-83% and exhibits with no overt toxicity, such as any weight loss when it is compared with the control group. After a period of treatment, the peak plasma concentration of PTUPB is high[1]. |
Molecular Weight | 543.56 |
Formula | C26H24F3N5O3S |
CAS No. | 1287761-01-6 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 100 mg/mL (183.97 mM), Need ultrasonic
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
PTUPB 1287761-01-6 代谢 免疫与炎症 神经科学 COX Epoxide Hydrolase Cyclooxygenase inhibit Non-alcoholic obesity Metastasis liver fatty steatosis HUVECs HFD hepatic Inhibitor LLC disease inhibitor