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PTUPB

PTUPB
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Purity:99.15%
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PTUPB

Catalog No. T12580Cas No. 1287761-01-6
PTUPB is a potent and dual inhibitor of sEH and COX-2 enzymes(IC50 of 0.9 nM and 1.26 μM, respectively).
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
1 mg$135In Stock
5 mg$289In Stock
10 mg$488In Stock
25 mg$798In Stock
50 mg$1,090In Stock
100 mg$1,480In Stock
1 mL x 10 mM (in DMSO)$346In Stock
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Product Introduction

Bioactivity
Description
PTUPB is a potent and dual inhibitor of sEH and COX-2 enzymes(IC50 of 0.9 nM and 1.26 μM, respectively).
In vitro
PTUPB has minimal inhibitory effects on cell proliferation in multiple cancer cell lines, including human melanoma cell and a transformed endothelial cell, whereas it potently inhibits HUVEC proliferation after 3 days of application[1].
In vivo
PTUPB inhibits LLC tumor growth by 70-83% and exhibits with no overt toxicity, such as any weight loss when it is compared with the control group. After a period of treatment, the peak plasma concentration of PTUPB is high[1].
Chemical Properties
Molecular Weight543.56
FormulaC26H24F3N5O3S
Cas No.1287761-01-6
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 100 mg/mL (183.97 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.8397 mL9.1986 mL18.3972 mL91.9862 mL
5 mM0.3679 mL1.8397 mL3.6794 mL18.3972 mL
10 mM0.1840 mL0.9199 mL1.8397 mL9.1986 mL
20 mM0.0920 mL0.4599 mL0.9199 mL4.5993 mL
50 mM0.0368 mL0.1840 mL0.3679 mL1.8397 mL
100 mM0.0184 mL0.0920 mL0.1840 mL0.9199 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg, each TargetMol | Animal experiments animal weighs 20 g, and the dosage volume is 100 μL. A total of TargetMol | Animal experiments 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL.
Mother liquor preparation method: 2 mg of drug dissolved in 50 μLDMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μLDMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μLTween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify.
1 Enter information below:
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