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AZ084

Name: AZ084
Brand: TargetMol
SKU: T10425
Price: 81 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T10425Cas No. 929300-19-6

AZ084 is a potent, selective, allosteric, and orally active CCR8 antagonist (Ki: 0.9 nM) with potential to treat asthma.

AZ084

🥰Excellent

Purity: 97.12%

Catalog No. T10425Cas No. 929300-19-6

AZ084 is a potent, selective, allosteric, and orally active CCR8 antagonist (Ki: 0.9 nM) with potential to treat asthma.

Pack Size	Price	Availability
1 mg	$81	In Stock
5 mg	$173	In Stock
10 mg	$273	In Stock
25 mg	$452	In Stock
50 mg	$636	In Stock
100 mg	$858	In Stock
200 mg	$1,150	In Stock
1 mL x 10 mM (in DMSO)	$191	In Stock

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Batch Information

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Purity:97.12%

Resource Download

COA HNMR HPLC LCMS

Product Introduction

Bioactivity

Description	AZ084 is a potent, selective, allosteric, and orally active CCR8 antagonist (Ki: 0.9 nM) with potential to treat asthma.
Targets&IC50	CCR8:0.9 nM (ki)

Chemical Properties

Molecular Weight	434.57
Formula	C₂₆H₃₄N₄O₂
Cas No.	929300-19-6
Smiles	CC1(C)Cc2c(O1)cccc2CN1CCC2(CC1)CCN(CC2)C(=O)c1ccc(N)cn1
Relative Density.	1.24 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 240 mg/mL (552.27 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3011 mL	11.5056 mL	23.0113 mL	115.0563 mL
5 mM	0.4602 mL	2.3011 mL	4.6023 mL	23.0113 mL
10 mM	0.2301 mL	1.1506 mL	2.3011 mL	11.5056 mL
20 mM	0.1151 mL	0.5753 mL	1.1506 mL	5.7528 mL
50 mM	0.0460 mL	0.2301 mL	0.4602 mL	2.3011 mL
100 mM	0.0230 mL	0.1151 mL	0.2301 mL	1.1506 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc