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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T35788 | Orlistat Degradation Product (sodium salt) | ||
Orlistat degradation product is a degradation product of the digestive lipase inhibitor orlistat . It is formed via hydrolytic and thermal degradation as well as digestion by human carboxyl ester lipase. | |||
T75026 | PROTAC TYK2 degradation agent1 | PROTACs | |
PROTAC TYK2 Degradation Agent1 is a potent, subtype-selective degrader of TYK2, exhibiting degradation activity with a DC50 of 14 nM. It is utilized in autoimmune disease research [1]. | |||
T4066 | FIN56 | Ferroptosis | |
FIN56 is a specific inducer of ferroptosis. | |||
T21572 | Erythromycin A enol ether | Others | |
Erythromycin A enol ether is a degradation product of Erythromycin A which is a macrolide antibiotic. | |||
T8858 | DTHIB | HSP | |
DTHIB robustly inhibits the HSF1 cancer gene signature and prostate cancer cell proliferation. | |||
T8710 | MSAB | Wnt/beta-catenin | |
MSAB is a selective inhibitor of Wnt/β-catenin signaling. MSAB binds to β-catenin, promoting its degradation, and specifically downregulates Wnt/β-catenin target genes. | |||
T39598 | 4-Chlorocatechol | Others | |
4-Chlorocatechol, a significant degradation product of 4-chloro-2-aminophenol (4C2AP), serves as a substrate for both catechol 1,2-dioxygenases and chlorocatechol dioxygenase [1] [2]. | |||
T20933 | Bis(p-chlorophenyl)acetic acid | Bis(p-chlorphenyl)essigsaeure,Bis(4-chlorophenyl)acetic acid,DDA (degradation product),DDA | |
Bis(p-chlorophenyl)acetic acid is a standard for pesticide residue analysis. | |||
T21773 | SP-141 | SP 141 | Mdm2 |
SP 141 is a MDM2 inhibitor.SP-141 promotes MDM2 auto-ubiquitination and degradation, with anticancer activity. | |||
T5436 | MZ 1 | Epigenetic Reader Domain | |
MZ 1 is a BRD4 protein degrader based on PROTAC technology. | |||
T17011 | TCH-165 | Proteasome | |
TCH-165 is a small molecule modulator of proteasome assembly, resulting in an increase in 20S levels. The increase in the level of free 20S corresponds to enhanced proteolysis of IDPs. | |||
T4940 | 3-Methylhistamine dihydrochloride | Others , Endogenous Metabolite | |
N tau-methylhistamine is one of the histamine metabolites. N tau-methylhistamine in plasma and urine is a good parameter for histamine release, and the determination of this histamine metabolite is generally less hampere... | |||
T8773 | MID-1 | Others , IGF-1R | |
MID-1 is an inhibitor of MG53-IRS-1 (Mitsugumin 53-Insulin Receptor Substrate-1) interaction. It disrupts molecular association of MG53 with IRS-1 and abolishes MG53-induced IRS-1 ubiquitination and degradation in skelet... | |||
T21616 | L-006235 | L 006235 | Cysteine Protease |
L-006235 is a potent and reversible inhibitor of cathepsin K with IC50 of 0.25 nM. | |||
T22922 | Lenalidomide hemihydrate | TNF , Ligand for E3 Ligase , Molecular Glues | |
Lenalidomide hemihydrate is a TNF-α secretion inhibitor (IC50 = 13 nM). Lenalidomide hemihydrate could bound endogenous CRBN and recombinant CRBN-DNA damage binding protein-1 (DDB1) complexes. | |||
T1919 | Tenovin-1 | Tenovin 1 | Mdm2 , Dehydrogenase , Sirtuin , p53 , Autophagy |
Tenovin-1 inhibits protein-deacetylating activities of SirT1 and SirT2 and protects against MDM2-mediated p53 degradation, which involves ubiquitination. | |||
T1818 | Tenovin-6 | Tenovin 6 | Dehydrogenase , Sirtuin , Autophagy |
Tenovin-6 is a p53 transcriptional activity agonist. | |||
T23820 | BRD32048 | BRD-32048,BRD 32048 | DNA/RNA Synthesis |
BRD32048 is the ETV1 transcription factor oncoprotein inhibitor. | |||
T12832 | Amcenestrant | SAR439859 | Estrogen Receptor/ERR , Estrogen/progestogen Receptor |
Amcenestrant (SAR439859) is an orally active, nonsteroidal and selective degrader of estrogen receptor (SERD). SAR439859 is a potent antagonist of ER (with an EC50 of 0.2 nM for ERα degradation). | |||
T8480 | Tenovin-6 Hydrochloride | Dehydrogenase , Sirtuin , HDAC , p53 , Autophagy | |
Tenovin-6 Hydrochloride is an SIRT1, SIRT2 and HDAC8 inhibitor(IC50s of 21 μM, 10 μM, and 67 μM for SirT1, SirT2, and SirT3, respectively), and is also a potent p53 activator . |