complications — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T1129	Benfotiamine	Benzoylthiamine monophosphate,S-Benzoylthiamine O-monophosphate	Others
	Benfotiamine (S-Benzoylthiamine O-monophosphate) is a synthetic S-acyl derivative of thiamine (vitamin B1), used as an antioxidant dietary supplement.		Others
TN6774	Emodin 6-O-β-D-glucoside	Glucoemodin	Others
	Emodin 6-O-β-D-glucoside (Glucoemodin) can protect barrier integrity and inhibit HMGB1-mediated inflammatory responses, which suggests a potential use as a therapy for sepsis or septic shock. Emodin 6-O-beta-D-glucoside ...		Others
T2755	Rhoifolin	Apigenin-7-O-rhamnoglucoside,Apigenin 7-O-neohesperidoside,Rhoifoloside	Others , p38 MAPK , NF-κB , transporter , IGF-1R , Autophagy
	Rhoifolin (Apigenin 7-O-neohesperidoside) is extracted from Turpinia arguya Seem dried leaves.
T16910	Sorbinil		Reductase
	Sorbinil is an Aldose reductase inhibitor. Sorbinil plays a therapeutic role in treating diabetes and diabetic complications decreases AR activity and inhibit the polyol pathway.		Reductase
T4S0295	Apigenin 7-glucoside	Cosmetin,Cosmosiin,Cosmosioside,Apigenin-7-O-β-D-glucopyranoside,Thalictiin,Apigetrin	Reactive Oxygen Species , HIV Protease
	1. Apigenin 7-glucoside (Cosmosiin) is a anti-HIV agent. 2. Cosmosiin may be beneficial for diabetic complications through their enhanced adiponectin secretion, tyrosine phosphorylation of insulin receptor-β and GLUT4 tr...		Reactive Oxygen Species , HIV Protease
TN2165	Rubrofusarin gentiobioside	Rubrofusarin-6-O-beta-D-gentiobioside	ERK , NF-κB , TGF-beta/Smad
	Rubrofusarin gentiobioside (Rubrofusarin-6-O-beta-D-gentiobioside) can significantly decrease the expression of TGF-beta1 and fibronectin and NF-kappaB DNA binding activity, suggests that it has potential as a preventive...		ERK , NF-κB , TGF-beta/Smad
T15756	Lidorestat	IDD-676	Reductase
	Lidorestat (IDD-676) is an aldose reductase inhibitor (IC50: 5 nM) with effective, selective and oral activity. Lidorestat improves nerve conduction and reduces the formation of cataracts. Lidorestat can be used to treat...		Reductase
T77523	ALR2-IN-1		Reductase
	ALR2-IN-1 is a potent and selective ALR2 inhibitor with an IC50 value of 1.42 μM.ALR2-IN-1 possesses both antiglycemic and antioxidant activities and can be used to study the complications of diabetes.		Reductase
T34268	Raxofelast	IRFI016,IRFI-016,IRFI 016
	Raxofelast (IRFI-016) is a hydrophilic, non-systemic, vitamin-like antioxidant that reduces ischemia-reperfusion injury in testis. Raxofelast is a good candidate compound for stopping oxidative stress after acute testicu...
T10183	6-Methoxytricin		Others
	6-Methoxytricin is a flavonoid isolated from Artemisia iwayomogi. It is an inhibitor on aldose reductase (AR) and advanced glycation endproduct (AGE) formation activities (IC50s: 30.29 μM and 134.88 μM). 6-Methoxytricin ...		Others
T5528	Cyanidin Chloride		Antioxidant
	Cyanidin Chloride, the main phenolic antioxidant in the grape (Vitis vinifera), in particular in the liposomal forms, could be used for treatment of diabetes mellitus complications.		Antioxidant
T21418	Lisinopril	Linopril,Zestril,Prinivil,Lisipril	RAAS
	Lisinopril (Prinivil), the angiotensin-converting enzyme (ACE) inhibitor, is used primarily in the treatment of high heart failure, blood pressure, and heart attacks. It is also used for preventing eye and kidney complic...		RAAS
T0688	Ganciclovir	BW 759,RS-21592,2'-Nor-2'-deoxyguanosine	Nucleoside Antimetabolite/Analog , Others , Antibiotic , Antifection , HSV
	Ganciclovir (2'-Nor-2'-deoxyguanosine) is an ACYCLOVIR analog that is a potent inhibitor of the Herpesvirus family including cytomegalovirus. Ganciclovir is used to treat complications from AIDS-associated cytomegaloviru...
T1273	Diacerein	Diacerhein,Fisiodar,Diacetylrhein	IL Receptor , Interleukin
	Diacerein (Fisiodar) is a prodrug which is metabolized to rhein. It is currently approved in France for the treatment of osteoarthritis although the use of diacerein is restricted due to the side effects including sevre ...		IL Receptor , Interleukin
T10393	AT-007		Reductase
	AT-007 is an orally active CNS penetrant Aldose Reductase inhibitor for the treatment of Galactosemia (IC50: 100 pM). It reduces toxic galactitol levels and prevents disease complications in GALT deficiency rats.		Reductase
T36619	Aligeron		Prostaglandin Receptor
	Aligeron is a non-selective prostaglandin (PG) antagonist that inhibits PGF2α- and PGE2-induced decreases in blood pressure in cats, and can be used to inhibit PGF2α-induced diarrhea in mice and PGE2-induced paw edema in...		Prostaglandin Receptor
T5S0384	Rhapontin	Ponticin,Rhaponiticin,Rhaponticin,Rhapontigenin glucoside	Apoptosis , Others
	1. Rhapontin (Ponticin) can alleviate liver steatosis and improve blood glucose and lipid profiles in KK/Ay diabetic mice, indicates that rhaponticin has a noticeable antidiabetic effect and could be potentially used as ...		Apoptosis , Others
T5S1988	Isorhamnetin-3-O-glucoside	Isorhamnetin-3-O-beta-D-Glucoside	Others
	Isorhamnetin-3-O-glucoside (Isorhamnetin-3-O-beta-D-Glucoside) inhibits the activity of alpha-glucosidase from rat intestine; it exhibits a potent rat lens aldose reductase (RLAR) inhibition in vitro, its IC(50) being 1....		Others
T21327	Uridine triacetate	RG 2133 triacetate,PN-401,Tri-O-acetyluridine,PN401,RG 2133,RG-2133,PN 401,RG2133,RG2133 triacetate	Others
	Uridine triacetate (RG 2133 triacetate) (Tri-O-acetyl uridine), an orally active prodrug of uridine, is efficiently absorbed in the gut and swiftly deacetylated in the circulation to release free uridine. It is utilized ...		Others
TN1042	Chebulic acid		Others
	Chebulic acid, a phenolcarboxylic acid compound isolated from Terminalia chebula, has potent anti-oxidant activity,which breaks the cross-links of proteins induced by advanced glycation end-products (AGEs) and inhibits t...		Others