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Ganciclovir

Catalog No. T0688 CAS 82410-32-0

Synonyms: BW 759, 2'-Nor-2'-deoxyguanosine, 更昔洛韦, RS-21592

Ganciclovir is an ACYCLOVIR analog that is a potent inhibitor of the Herpesvirus family including cytomegalovirus. Ganciclovir is used to treat complications from AIDS-associated cytomegalovirus infections.

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Ganciclovir, CAS 82410-32-0

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Ganciclovir is an ACYCLOVIR analog that is a potent inhibitor of the Herpesvirus family including cytomegalovirus. Ganciclovir is used to treat complications from AIDS-associated cytomegalovirus infections.
Targets&IC50	herpesvirus type-1 (FHV-1):5.2 μM
In vivo	In adult rats, the intracochlear diffusion of ganciclovir is shown to achieve the same concentration as in blood. In gestating mice, transplacental diffusion is observed, with a fetal-to-maternal blood ratio of 0.5. In newborn mice, the plasma concentration profile of ganciclovir shows a peak at 2 h followed by a gradual decrease. In adult mice, the concentration peaked at 1 h, but becomes undetectable by 2 h after injection. Counts of white blood cells, red blood cells and platelets decreases significantly in ganciclovir-treated newborn mice[7].
Kinase Assay	For assessment of Akt protein kinase activity in vitro, substrate (2 μg histone H2B or 25 μg eNOS peptide) is incubated with Akt immunoprecipitated from cell lysate using goat polyclonal anti-Akt1 antibody. Kinase reactions are initiated following the addition of reaction components to a final concentration of ATP (50 μM) containing 10 μCi of 32P-γATP, dithiotreitol (1 mM), HEPES buffer (20 mM, pH 7.4), MnCl2 (10 mM), MgCl2 (10 mM). After incubation for 30 min at 30°C, phosphorylated histone H2B is visualized after SDS-PAGE (15%) and autoradiography. To estimate the extent of 32P incorporation into eNOS peptides, each reaction mixture is measured by spotting onto phosphocellulose disc filter and the amount of phosphate incorporated is measured by Cerenkov counting. The wild-type peptide sequence is 1174-RIRTQSFSLQERHLRGAVPWA-1194, and the mutant eNOS peptide is identical except that serine 1179 is substituted by alanine.

Synonyms	BW 759, 2'-Nor-2'-deoxyguanosine, 更昔洛韦, RS-21592
Molecular Weight	255.234
Formula	C9H13N5O4
CAS No.	82410-32-0

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 50 mg/mL (195.9 mM)

Ethanol: <1 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Matthews T, et al. Rev Infect Dis, 1988, 10, S490-494. 2. Hamel W, et al. Cancer Res, 1996, 56(12), 2697-2702. 3. St Clair MH, et al. Antimicrob Agents Chemother, 1987, 31(6), 844-849. 4. Wei SJ, et al. Exp Cell Res, 1998, 241(1), 66-75. 5. Rubsam LZ, et al. Cancer Res, 1998, 58(17), 3873-3882. 6. BoujemLa I, et al. Pharmacokinetics and tissue diffusion of ganciclovir in mice and rats. Antiviral Res. 2016 Aug;132:111-5. 7. Zhao M, Wang B, Zhang C, et al. The DJ1-Nrf2-STING axis mediates the neuroprotective effects of Withaferin A in Parkinson’s disease[J]. Cell Death & Differentiation. 2021: 1-19. 8. Wilbertz J H, Voigt F, Horvathova I, et al. Single-molecule imaging of mRNA localization and regulation during the integrated stress response[J]. Molecular cell. 2019 Mar 7;73(5):946-958.e7. 9. Horvathova I, Voigt F, Kotrys A V, et al. The dynamics of mRNA turnover revealed by single-molecule imaging in single cells[J]. Molecular cell. 2017 Nov 2;68(3):615-625.e9.

Citations

1. Horvathova I, Voigt F, Kotrys A V, et al. The dynamics of mRNA turnover revealed by single-molecule imaging in single cells. Molecular cell. 2017 Nov 2;68(3):615-625.e9. 2. Wilbertz J H, Voigt F, Horvathova I, et al. Single-molecule imaging of mRNA localization and regulation during the integrated stress response. Molecular cell. 2019 Mar 7;73(5):946-958.e7. 3. Zhao M, Wang B, Zhang C, et al. The DJ1-Nrf2-STING axis mediates the neuroprotective effects of Withaferin A in Parkinson’s disease. Cell Death & Differentiation. 2021: 1-19.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Compound Library Antibiotics Library Inhibitor Library Drug-induced Liver Injury (DILI) Compound Library Nucleotide Compound Library DNA Damage & Repair Compound Library Immunology/Inflammation Compound Library Drug Repurposing Compound Library Anti-Cancer Approved Drug Library FDA-Approved Drug Library

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Keywords

Ganciclovir 82410-32-0 DNA损伤和修复其他微生物学细胞周期 Antibiotic Antifection HSV Nucleoside Antimetabolite/Analog Others CMV Inhibitor DNA viruse BW-759 group infection BW 759 CNS penetration Cytomegalovirus BW759 serotype Herpes simplex virus replication orally active polymerase inhibit herpes 2'-Nor-2'-deoxyguanosine RS-21592 inhibitor

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