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Ganciclovir

Catalog No. T0688   CAS 82410-32-0
Synonyms: BW 759, RS-21592, 2'-Nor-2'-deoxyguanosine

Ganciclovir (2'-Nor-2'-deoxyguanosine) is an ACYCLOVIR analog that is a potent inhibitor of the Herpesvirus family including cytomegalovirus. Ganciclovir is used to treat complications from AIDS-associated cytomegalovirus infections.

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Ganciclovir Chemical Structure
Ganciclovir, CAS 82410-32-0
Pack Size Availability Price/USD Quantity
100 mg In stock $ 51.00
1 g In stock $ 75.00
1 mL * 10 mM (in DMSO) In stock $ 50.00
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Purity: 99.55%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Ganciclovir (2'-Nor-2'-deoxyguanosine) is an ACYCLOVIR analog that is a potent inhibitor of the Herpesvirus family including cytomegalovirus. Ganciclovir is used to treat complications from AIDS-associated cytomegalovirus infections.
Targets&IC50 FHV-1:5.2 μM
In vivo In adult rats, the intracochlear diffusion of ganciclovir is shown to achieve the same concentration as in blood. In gestating mice, transplacental diffusion is observed, with a fetal-to-maternal blood ratio of 0.5. In newborn mice, the plasma concentration profile of ganciclovir shows a peak at 2 h followed by a gradual decrease. In adult mice, the concentration peaked at 1 h, but becomes undetectable by 2 h after injection. Counts of white blood cells, red blood cells and platelets decreases significantly in ganciclovir-treated newborn mice[7].
Kinase Assay For assessment of Akt protein kinase activity in vitro, substrate (2 μg histone H2B or 25 μg eNOS peptide) is incubated with Akt immunoprecipitated from cell lysate using goat polyclonal anti-Akt1 antibody. Kinase reactions are initiated following the addition of reaction components to a final concentration of ATP (50 μM) containing 10 μCi of 32P-γATP, dithiotreitol (1 mM), HEPES buffer (20 mM, pH 7.4), MnCl2 (10 mM), MgCl2 (10 mM). After incubation for 30 min at 30°C, phosphorylated histone H2B is visualized after SDS-PAGE (15%) and autoradiography. To estimate the extent of 32P incorporation into eNOS peptides, each reaction mixture is measured by spotting onto phosphocellulose disc filter and the amount of phosphate incorporated is measured by Cerenkov counting. The wild-type peptide sequence is 1174-RIRTQSFSLQERHLRGAVPWA-1194, and the mutant eNOS peptide is identical except that serine 1179 is substituted by alanine.
Synonyms BW 759, RS-21592, 2'-Nor-2'-deoxyguanosine
Molecular Weight 255.23
Formula C9H13N5O4
CAS No. 82410-32-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 5.63 mg/mL (22.04 mM), Sonication is recommended.

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

TargetMolReferences and Literature

1. Matthews T, et al. Rev Infect Dis, 1988, 10, S490-494. 2. Hamel W, et al. Cancer Res, 1996, 56(12), 2697-2702. 3. St Clair MH, et al. Antimicrob Agents Chemother, 1987, 31(6), 844-849. 4. Wei SJ, et al. Exp Cell Res, 1998, 241(1), 66-75. 5. Rubsam LZ, et al. Cancer Res, 1998, 58(17), 3873-3882. 6. BoujemLa I, et al. Pharmacokinetics and tissue diffusion of ganciclovir in mice and rats. Antiviral Res. 2016 Aug;132:111-5. 7. Zhao M, Wang B, Zhang C, et al. The DJ1-Nrf2-STING axis mediates the neuroprotective effects of Withaferin A in Parkinson’s disease[J]. Cell Death & Differentiation. 2021: 1-19. 8. Wilbertz J H, Voigt F, Horvathova I, et al. Single-molecule imaging of mRNA localization and regulation during the integrated stress response[J]. Molecular cell. 2019 Mar 7;73(5):946-958.e7. 9. Horvathova I, Voigt F, Kotrys A V, et al. The dynamics of mRNA turnover revealed by single-molecule imaging in single cells[J]. Molecular cell. 2017 Nov 2;68(3):615-625.e9.

TargetMolCitations

1. Horvathova I, Voigt F, Kotrys A V, et al. The dynamics of mRNA turnover revealed by single-molecule imaging in single cells. Molecular cell. 2017 Nov 2;68(3):615-625.e9. 2. Wilbertz J H, Voigt F, Horvathova I, et al. Single-molecule imaging of mRNA localization and regulation during the integrated stress response. Molecular cell. 2019 Mar 7;73(5):946-958.e7. 3. Zhao M, Wang B, Zhang C, et al. The DJ1-Nrf2-STING axis mediates the neuroprotective effects of Withaferin A in Parkinson’s disease. Cell Death & Differentiation. 2021: 1-19.

Related compound libraries

This product is contained In the following compound libraries:
EMA Approved Drug Library Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library Inhibitor Library Anti-Cancer Approved Drug Library Drug Repurposing Compound Library Orally Active Compound Library Hematopoietic Toxicity Compound Library FDA-Approved Drug Library Approved Drug Library

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Keywords

Ganciclovir 82410-32-0 Cell Cycle/Checkpoint DNA Damage/DNA Repair Microbiology/Virology Others Antibiotic HSV Antifection Nucleoside Antimetabolite/Analog CMV Inhibitor DNA BW-759 Herpes simplex virus RS 21592 serotype viruse BW 759 herpes inhibit RS-21592 BW759 polymerase orally active replication group infection CNS penetration Cytomegalovirus 2'-Nor-2'-deoxyguanosine RS21592 inhibitor

 

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